Prevalence, awareness, and burden of major depressive disorder in urban China

Gupta, Shaloo; Goren, Amir; Dong, Peng; Liu, Dongdong

doi:10.1586/14737167.2016.1102062

Cited by 39 publications

(36 citation statements)

References 36 publications

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“…The prevalence of MDD between different regions in China varied from 1% to 6.5% [19–21]. MDD prevalence in urban China was 6.0% with a relatively low diagnosed rate (8.3%) and only 51.5% currently used prescription medication for depression [22]. Our study reported that the prevalence of depressive symptom was 5.9% in rural Northeast China which seemed to be close to the urban areas [23].…”

Section: Discussionmentioning

confidence: 86%

Metabolic syndrome and depressive symptoms among rural Northeast general population in China

Yang

Guo

et al. 2017

BMC Public Health

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BackgroundPrevious researches aiming to estimate the association between metabolic syndrome and depressive symptoms come out with inconsistent results. Besides, most of them are conducted in the developed areas. There is lack of the data from rural China. The aim of this study is to confirm whether gender difference exists among the relationship between MetS, metabolic components and depressive symptoms in the rural Chinese population.MethodsA cross-sectional analysis enrolled 11430 subjects’ aged ≥35 from rural Northeast China. Metabolic and anthropometric indicators were measured according to standard methods. Depressive symptoms were defined using the Patient Health Questionnaire-9 (PHQ-9).ResultsThe prevalence of depressive symptoms was 6% among rural Northeast general population and the prevalence of MetS and its components were 39.0% for MetS, 42.9% for abdominal obesity, 67.1% for elevated blood pressure, 47.1% for hyperglycemia, 32.1% for hypertriglyceridemia, 29.5% for low HDL-C. Depressive symptoms were associated with triglyceride component (OR = 1.24, 95%CI: 1.05–1.46, P = 0.01) but not MetS (OR = 1.11, 95%CI: 0.94–1.30, P = 0.23). Moreover, depressive symptoms were associated with triglyceride component (OR = 1.21, 95% CI = 1.00–1.47, P = 0.05) in women only. But once adjusted for menopause status, depressive symptoms were no longer statically associated with triglyceride component (OR = 1.20, 95% CI = 0.99–1.46, P = 0.07).ConclusionsDepressive symptoms were associated with triglyceride component but not MetS in rural Chinese population. Routine lipid screening should be recommended among rural depressed residents especially among female.

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Section: Discussionmentioning

confidence: 86%

Metabolic syndrome and depressive symptoms among rural Northeast general population in China

Yang

Guo

et al. 2017

BMC Public Health

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“…As a productivity outcome, previous reports have identified impairments in the ability of depressed patients to perform nonwork-related routine day-to-day activities (or activity impairment) 20,21. Antidepressant treatment results in reduced activity impairment 22.…”

Section: Introductionmentioning

confidence: 99%

Daily activity level improvement with antidepressant medications predicts long-term clinical outcomes in outpatients with major depressive disorder

Jha¹,

Teer²,

Minhajuddin

et al. 2017

NDT

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BackgroundMajor depressive disorder (MDD) significantly impacts performance of both work- and nonwork-related routine daily activities. We have shown that work productivity is significantly impaired in employed MDD patients, but the extent of impairments in nonwork-related routine activities and its association with antidepressant treatment outcomes has not been established.Materials and methodsActivity impairment was measured using the sixth item of Work Productivity and Activity Impairment Scale in the Combining Medications to Enhance Depression Outcomes (CO-MED) trial (n=665). Published norms were used to define activity impairment levels. The relationship between activity impairment and baseline sociodemographic and clinical characteristics was evaluated along with changes in activity impairment and its relationship with other clinical outcomes such as symptom severity, function, and side effect burden. Remission status at 3 and 7 months was predicted based on week 6 activity impairment level.ResultsHigher psychosocial and cognitive impairments and greater number of comorbid medical conditions were associated with greater activity impairment at baseline. Proportion of participants with severe activity impairment declined from 47.6% at baseline to 18.7% at 3 months, while mean activity impairment decreased from 57.1 at baseline to 32.8 at 3 months. During course of treatment, levels of activity impairment correlated most strongly with psychosocial function among measures of symptom severity, function, quality of life, and side effect burden. No or minimal activity impairment at week 6 was associated with two to three times higher rates of remission at 3 and 7 months as compared to moderate or severe activity impairment levels even after controlling for remission status at week 6 and select baseline variables.ConclusionDepressed patients have high levels of nonwork-related activity impairment at baseline that improves significantly with treatment and independently predicts long-term clinical outcomes. Brief systematic assessment of activity impairment during the course of antidepressant treatment can help inform clinical decision-making.

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“…162 Based on the 2012 China National Health and Wellness Survey, the prevalence of mental health disorders was 6% in urban areas. 163 Highly populated cities along the eastern coast (such as Shenyang and Shanghai) and cities in west China that have high population densities had poorer depression scale scores than did other cities. 164 The prevalence of mental health problems is high among migrant workers.…”

Section: Mental Disorders Statusmentioning

confidence: 97%

“…People with such disorders reported lower health-related quality of life scores and had lower productivity and resource utilisation. 163…”

Section: Mental Disorders Statusmentioning

confidence: 99%

The Tsinghua–Lancet Commission on Healthy Cities in China: unlocking the power of cities for a healthy China

et al. 2018

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Prevalence, awareness, and burden of major depressive disorder in urban China

Abstract: MDD in urban China may be under-diagnosed and undertreated. Awareness and better access to treatments may help alleviate the burden of MDD.

Cited by 39 publications

References 36 publications

Metabolic syndrome and depressive symptoms among rural Northeast general population in China

Metabolic syndrome and depressive symptoms among rural Northeast general population in China

Daily activity level improvement with antidepressant medications predicts long-term clinical outcomes in outpatients with major depressive disorder

The Tsinghua–Lancet Commission on Healthy Cities in China: unlocking the power of cities for a healthy China

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