Prevalence and vertical transmission of human pegivirus among pregnant women infected with <scp>HIV</scp>

Santos, Lucas M.; Lobato, Rubens Cáurio; Barral, Maria Fernanda Martínez; Gonçalves, Carla Vitola; Hora, Vanusa Pousada da; Martínez, Ana Maria Barral de

doi:10.1002/ijgo.12175

Cited by 14 publications

(15 citation statements)

References 28 publications

(68 reference statements)

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“…The prevalence of HPgV among the individuals diagnosed with HIV-1 in this study was 9,7% higher than that reported by Miranda et al [38]. The high prevalence of HPgV among HIV-1 individuals has been reported in several studies in Brazil and the world [40][41][42]. The association between the presence of HPgV and HIV is owing to the fact that HPgV likely acts as a protective factor for the development of HIV [40,43,44].…”

Section: Discussioncontrasting

confidence: 43%

Human pegivirus (HPgV, GBV-C) RNA prevalence, genome characterization and association with HIV coinfection among volunteer blood donors from a public hemotherapy service in Northern Brazil.

Silva

Barata

et al. 2020

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BackgroundHuman pegivirus (HPgV) - formerly known as GBV-C - is a member of the Flaviviridae family and belongs to the species Pegivirus C. It is a non-pathogenic virus and is transmitted among humans mainly through the exposure to contaminated blood and is often associated with human immunodeficiency virus (HIV) infection. This study aimed to determine the prevalence of HPgV viremia, its association with HIV and clinical epidemiological factors, as well as the full-length sequencing and genome characterization of HPgV recovered from blood donors of the HEMOPA Foundation in Belém-PA-BrazilMethodsPlasma samples were obtained from 459 donors, tested for the presence of HPgV RNA by the RT-qPCR. From these, a total of 26 RT-qPCR positive samples were submitted to the NGS sequencing approach in order to obtain the full genome+. Genome characterization and phylogenetic analysis were conducted.ResultsThe prevalence of HPgV was 12.42%. We observed the highest prevalences among donors aged between 18 to 30 years old (16.5%), with brown skin color (13.2%) and men (15.8%). The newly diagnosed HIV-1 prevalence was 26.67%. The genotype 2 (2A and 2B) was identified. No data on viral load value was found to corroborate the protective effect of HPgV on HIV evolution.ConclusionsThis study provided information regarding the HPgV infection among blood donors from HEMOPA Foundation. Furthermore, we genetically characterized the HPgV circulating strains and described by the first time the genotype 2 genomes in the Brazilian Amazon region.

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Section: Discussioncontrasting

confidence: 43%

Human pegivirus (HPgV, GBV-C) RNA prevalence, genome characterization and association with HIV coinfection among volunteer blood donors from a public hemotherapy service in Northern Brazil.

Silva

Barata

et al. 2020

Preprint

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“…HPgV-1 can be transmitted through parenteral, sexual, or motherto-child routes. [16][17][18][19] Coinfection with HIV or hepatitis C virus (HCV) is common due to shared transmission modes and also in those exposed to transfused blood products, transplanted patients, injection drug users, hemophiliacs, and patients requiring hemodialysis. 20 In the general population, the prevalence of HPgV-1 ranges from 1% to 4% in North America and Europe and from 5% to 19% in Africa, Asia, and South America.…”

mentioning

confidence: 99%

High prevalence and autochtonous transmission of human pegivirus (HPgV‐1) in blood donors in the extreme southern of Brazil

Mota

Finger‐Jardim

Silva

et al. 2018

Journal of Medical Virology

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Recent studies have suggested that human pegivirus 1 (HPgV-1) may have some pathogenic potential. In the southernmost region of Brazil, studies on HPgV-1 are scarce, and circulating genotypes have not yet been identified. The current study aimed to evaluate the prevalence of HPgV-1 among blood donors from the southernmost region of Brazil and identify the genotypes involved with associated factors. A cross-sectional study was conducted with 281 blood donors, who had their plasma subjected to RNA extraction, complementary DNA synthesis, HPgV-1 detection by nested polymerase chain reaction, and subsequent genotyping. The observed prevalence of HPgV-1-RNA was 21.7%. The only variable that was significantly associated with virus infection was the relationship status of the donor. Single or no fixed partner blood donors were twice as likely to have HPgV-1 (95% CI, 1.12 to 4.56; P = 0.02). Genotype 2-subtypes 2b (69%) and 2a (29%)-was the most prevalent. In the absence of risk factors for parenteral transmission, it is likely that sexual transmission was the route of infection in the individuals studied. Further work will be needed to determine whether this virus is inert in the population, or if there are potential deleterious effects in infected individuals.

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“…This reduced prevalence of HPgV-1 infection compared to most reported papers in the literature may be explained by the method used (only viral RNA was used for diagnosis) [7,14,21,26] and a more advanced age. Individuals between 18 to 30 and 31 to 50 years are approximately eight and six times, respectively more prone to show HPgV infection than those older than 50 years [19].…”

Section: Plos Onementioning

confidence: 71%

“…Other studies have also investigated the prevalence of HPgV-1 in healthy blood donors in the South Region, and the results indicated a seroprevalence between 5.9% [6] and 21.7% [19]. In people living with HIV, the prevalence of HPgV-1 infection was 34% [20], and vertical transmission of HPgV-1 in pregnant women with HIV was 31% [21].…”

Section: Plos Onementioning

confidence: 99%

Low prevalence of human pegivirus 1 (HPgV-1) in HTLV-1 carriers from Belém, Pará, North Region of Brazil

et al. 2020

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Data Availability Statement: All relevant data are within the manuscript. respectively. No significant differences were found when comparing any clinical or demographic data between groups. Conclusion This study indicated that the prevalence of HPgV-1 infection is low in HTLV-1 carriers in Belé m, Pará , and probably does not alter the clinical course of HTLV-1 infection, however, further studies are still needed.

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Prevalence and vertical transmission of human pegivirus among pregnant women infected with HIV

Abstract: Prenatal care could protect against vertical transmission of HPgV among women infected with HIV; however, studies among HIV-negative individuals are still required to verify this correlation.

Cited by 14 publications

References 28 publications

Human pegivirus (HPgV, GBV-C) RNA prevalence, genome characterization and association with HIV coinfection among volunteer blood donors from a public hemotherapy service in Northern Brazil.

Human pegivirus (HPgV, GBV-C) RNA prevalence, genome characterization and association with HIV coinfection among volunteer blood donors from a public hemotherapy service in Northern Brazil.

High prevalence and autochtonous transmission of human pegivirus (HPgV‐1) in blood donors in the extreme southern of Brazil

Low prevalence of human pegivirus 1 (HPgV-1) in HTLV-1 carriers from Belém, Pará, North Region of Brazil

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