Prevalence and Underlying Etiologies of Neonatal Hypoglycemia

Najati, N; Saboktakin, Lida

doi:10.3923/pjbs.2010.753.756

Cited by 22 publications

(21 citation statements)

References 11 publications

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“…The reported incidence of hypoglycemia varies a lot due to controversies regarding definition of neonatal hypoglycemia and criteria for diagnosis of hypoglycemia. A study from Iran has taken blood sugar levels less than 50mg/dl as criteria for diagnosis of hypoglycemia [4]. Similar to some recent Chinese and Indian studies [5,6].…”

Section: Discussionmentioning

confidence: 94%

Study of incidence, clinical profile and risk factors of neonatal hypoglycemia in a tertiary care hospital

R¹,

Souza²,

C³

2016

Int J Pediatr Res

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Background: The reported incidence of hypoglycemia varies with its definition. The clinical manifestations of hypoglycemia are nonspecific and similar to those of many disorders in newborn infants. Persistent hypoglycemia is more likely to be associated with possible neurologic sequelae. However, its definition, clinical significance, and management remain controversial. Methods: This prospective observational study was done over a period of 2 years. Babies admitted to Neonatal intensive care unit with whole blood sugar levels <40 mg/dl and fulfilling inclusion criteria were taken up for the study. These babies were subjected to detailed history taking, thorough clinical examination and investigations. The babies were observed for signs and symptoms of hypoglycemia. Results: Neonatal hypoglycemia constituted about 8.26%. Majority of hypoglycemic babies were preterm babies. Asymptomatic hypoglycemia was predominantly noticed in preterm babies (65.21%). Term babies (58.82%) showed more symptoms with hypoglycemia than preterm babies. The major clinical manifestations are jitteriness, lethargy, convulsions and apneic spells. PIH and prematurity are most associated risk factors. Significantly low Sugar levels (p value <0.005) were noticed in symptomatic hypoglycemic babies. Conclusion: Hypoglycemia in neonates can have variable presentations indicating the need for detailed and thorough examination for evidence of hypoglycemia. Identification of risk factors of hypoglycemia and proper monitoring blood glucose levels should be done to plan early treatment and prevent neurological damage.

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Section: Discussionmentioning

confidence: 94%

Study of incidence, clinical profile and risk factors of neonatal hypoglycemia in a tertiary care hospital

R¹,

Souza²,

C³

2016

Int J Pediatr Res

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“…5 Sepsis has been known to be the cause of 9.6% cases of neonatal hypoglycemia. 6 A neonate having sepsis develops reluctance to feed and this can lead to hypoglycemia. Similarly increased metabolic demand and hypothermia caused by sepsis can bring down the glucose level.…”

Section: Introductionmentioning

confidence: 99%

Glycemic Status and its Effect in Neonatal Sepsis in a Tertiary Care Hospital

Islam¹,

Mia²,

Akhter³

et al. 2017

Bangladesh J Child Health

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“…Prematurity (61.5%) was the leading cause of death. A percentage of 1.9% of these deaths were reportedly due to CHI [40]. Whereas data on the IMR DOI: 10.1159/000506476 in neonates due to hypoglycemia are otherwise not available, it could be speculated that even a higher proportion of neonatal deaths worldwide could be due to CHI.…”

Section: Discussionmentioning

confidence: 99%

Congenital Hyperinsulinism Caused by Novel Homozygous K<sub>ATP</sub> Channel Gene Variants May Be Linked to Unexplained Neonatal Deaths among Kurdish Consanguineous Families

et al. 2020

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Congenital hyperinsulinism (CHI) is a potentially life-threatening cause of severe hypoglycemia in the neonatal and infant period. • The incidence of CHI has been estimated to be around 1 in 50,000 in non-consanguineous populations and as high as 1 in 2,500 in areas with a higher rate of consanguinity. • Certain countries with high rates of consanguinity have a much higher infant and neonatal mortality rate than the rest of the world. Novel Insights• Three novel homozygous variants are reported in genes ABCC8 and KCNJ11 causing CHI in three Kurdish consanguineous families. Two of these families have a notable history of unexplained neonatal deaths. • A small but significant percentage of all unexplained neonatal deaths could be due to undiagnosed CHI. Therefore, especially in regions with a high prevalence of consanguinity, undiagnosed CHI can contribute to higher infant and neonatal mortality rates. AbstractIntroduction: Neonatal hypoglycemia due to congenital hyperinsulinism (CHI) is a potentially life-threatening condition. Biallelic pathogenic variants in K ATP channel subunit genes (ABCC8, KCNJ11), causing severe forms of CHI, are more prevalent in regions with a significant rate of consanguinity and may lead to unexplained neonatal deaths. We hypothesized that K ATP channel gene variants are the cause of CHI in three unrelated children from consanguineous

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Prevalence and Underlying Etiologies of Neonatal Hypoglycemia

Cited by 22 publications

References 11 publications

Study of incidence, clinical profile and risk factors of neonatal hypoglycemia in a tertiary care hospital

Study of incidence, clinical profile and risk factors of neonatal hypoglycemia in a tertiary care hospital

Glycemic Status and its Effect in Neonatal Sepsis in a Tertiary Care Hospital

Congenital Hyperinsulinism Caused by Novel Homozygous K<sub>ATP</sub> Channel Gene Variants May Be Linked to Unexplained Neonatal Deaths among Kurdish Consanguineous Families

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