Prevalence and types of childhood trauma in first episode psychosis patients. Relation with clinical onset variables

Cacho, N. Del; Butjosa, Anna; Arumí, C Serra; Santjusto, M. Esteban; Cuevas‐Esteban, Jorge; Morello, G; Pardo, Marta; Muñoz-Samons, Daniel; Usall, Judith; Abella, Manuel; Ahicart, A.; Álvarez, María-José; Arranz, Belén; Barneda, V.; Bañuelos, M.; Bogas, J.L.; Bonilla, Rosalba Rosales; Camprodon, Ester; Casado, Ana María Martín; Casali, T.; Chavarría, V.; Colomer, Belén Fernández; Coromina, Marta; Cuautle, A.; Esteban, Jorge Cuevas; Cunill, Ruth; Cuñat, O.; Hoyo, B. del; Delisau, Y.; Diago, M.; Dolz, Montse; Esteban-Santjusto, M.; Estrada, X.; Ferrer, I.; Grases, N.; Iglesias-González, María; Jane, C.; Ledesma-Ipaguirre, G.; Ortiz, Cynthia; Membrive, P.; Miñambres, Aitor; Molano, Ana; Núñez, Christian; Núñez, Marian Amanda Vázquez; Ochoa, Susana; Pastrana, N.; Pelaéz, Trini; Pla, M.M.; Redin, J.; I, Riera- Lopez de Aguileta; Rodriguez, M.; Romans, C.; Rubio‐Abadal, Elena; Ruiz, Ernesto; Saenz-Navarrete, G.; Saltó, C.; Santos, Anemari Ramos Dinarte dos; Serra‐Arumí, Clara; Sibelo, S.; Sole, L.; Soler, A.; Teba, S.; Via, Esther; Vila‐Badia, Regina; Vives, L.

doi:10.1016/j.jpsychires.2021.12.033

Cited by 9 publications

(4 citation statements)

References 68 publications

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“…We also replicate previous findings supporting that physical (Gil et al, 2009) and emotional neglect is associated with higher impairment in social functioning in PD (Christy et al, 2022;Sideli et al, 2022) than other CM subtypes. We found associations between sexual abuse and global social functioning, which is a novel finding maybe due to additional (Aas et al, 2016;Akbey et al, 2019;Garcia et al, 2016;Gil et al, 2009) and newly (Vila-Badia et al, 2022) included studies leading to bigger sample sizes to examine this association (that was not significant in the previous meta-analysis) (Christy et al, 2022). The fact that findings generally replicated across subtypes of CM raises further questions about the underlying mechanisms that are altered by these diverse adverse childhood experiences, with likely broad consequences for social outcomes.…”

Section: Discussionmentioning

confidence: 58%

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Examining associations, moderators and mediators between childhood maltreatment, social functioning, and social cognition in psychotic disorders: a systematic review and meta-analysis

et al. 2023

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Childhood maltreatment (CM) has been related to social functioning and social cognition impairment in people with psychotic disorders (PD); however, evidence across different CM subtypes and social domains remains less clear. We conducted a systematic review and meta-analysis to quantify associations between CM, overall and its different subtypes (physical/emotional/sexual abuse, physical/emotional neglect), and domains of social functioning and social cognition in adults with PD. We also examined moderators and mediators of these associations. A PRISMA-compliant systematic search was performed on 24 November 2022 (PROSPERO CRD42020175244). Fifty-three studies (N = 13 635 individuals with PD) were included in qualitative synthesis, of which 51 studies (N = 13 260) with 125 effects sizes were pooled in meta-analyses. We found that CM was negatively associated with global social functioning and interpersonal relations, and positively associated with aggressive behaviour, but unrelated to independent living or occupational functioning. There was no meta-analytic evidence of associations between CM and social cognition. Meta-regression analyses did not identify any consistent moderation pattern. Narrative synthesis identified sex and timing of CM as potential moderators, and depressive symptoms and maladaptive personality traits as possible mediators between CM and social outcomes. Associations were of small magnitude and limited number of studies assessing CM subtypes and social cognition are available. Nevertheless, adults with PD are at risk of social functioning problems after CM exposure, an effect observed across multiple CM subtypes, social domains, diagnoses and illness stages. Maltreated adults with PD may thus benefit from trauma-related and psychosocial interventions targeting social relationships and functioning.

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Section: Discussionmentioning

confidence: 58%

“…Prevalence can vary across populations, but some reports show rates as high as 85% in schizophrenia spectrum disorders and 77% in affective psychoses (Larsson et al, 2013 ). At least one subtype of CM is reported by around half of individuals with FEP (Vila-Badia et al, 2022 ), and schizophrenia (Morgan & Fisher, 2007 ).…”

Section: Introductionmentioning

confidence: 99%

Examining associations, moderators and mediators between childhood maltreatment, social functioning, and social cognition in psychotic disorders: a systematic review and meta-analysis

et al. 2023

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“…43 Some novel data suggest that around 61% of patients with the first psychotic episode reported having experienced some kind of childhood trauma. 44 Early life distress can influence the development of the hypothalamic-pituitary-adrenal (HPA) axis. 45 If adverse experience occurs only once, as a strong acute stressor, HPA axis function will probably be reflected through hypercortisolemia.…”

Section: Childhood Abuse or Neglect Early Life Distress And Schizophr...mentioning

confidence: 99%

Impact of Childhood Adversity, as Early Life Distress, on Cytokine Alterations in Schizophrenia

Miljević¹,

Munjiza-Jovanovic²,

Jovanovic³

2023

NDT

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Even though inflammation theory has been introduced in the pathophysiology of psychosis almost a century ago, many of its aspects have remained unelucidated. Numerous studies have shown cytokine dysregulation in schizophrenia and a predominance of proinflammatory cytokines, but on another side, various cytokines in a pro-inflammatory group have different trends in all subtypes of schizophrenia. Alterations are also present in anti-inflammatory and regulatory cytokines, but findings are still not consistent. On the other hand, it is well known that abuse and neglect in childhood may be predictors of psychotic disorders, and childhood adversity is also associated with alterations of the immune and inflammatory response (through various mechanisms including HPA dysregulation as well). This review aims to analyze conducted studies and elucidate the link between childhood abuse, schizophrenia, and cytokine alterations. Putting together this complex psycho-immunological puzzle for the subgroup of schizophrenia-diagnosed patients with distinct immunological abnormalities and a history of childhood abuse can help us to answer the question about the future treatment of these patients.

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“…Positive psychotic symptoms have been particularly related to CT in patients with schizophrenia (SCZ) (Ross, Anderson, & Clark, 1994;Üçok & Bıkmaz, 2007). Although some studies reported an association of negative symptoms with childhood abuse and neglect (Uyan, Baltacioglu, & Hocaoglu, 2022;Van Dam et al, 2015;Vila-Badia et al, 2022), others found no relationship in patients with psychosis (Şahin et al, 2013;Üçok & Bıkmaz, 2007;Werbeloff et al, 2021). Although little is known about the relationship between specific types of trauma and specific symptoms, there is some evidence that type of trauma is related to type of psychotic symptoms.…”

Section: Introductionmentioning

confidence: 99%

The relationship between childhood trauma, psychotic symptoms, and cognitive schemas in patients with schizophrenia, their siblings, and healthy controls: results from the EU-GEI study

Üçok,

Noyan,

Gülöksüz

et al. 2024

Psychol. Med.

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Background The relationship between childhood trauma (CT) and psychotic symptoms in patients with schizophrenia (SCZ), and subthreshold psychotic experiences in non-clinical populations is well-established. However, little is known about the relationship between subtypes of trauma and specific symptoms in patients, their siblings, and controls. It is also not clear which variables mediate the relationship between trauma and psychotic symptoms. Methods Seven hundred and forty-two patients with SCZ, 718 of their unaffected siblings and 1039 controls from three EU-GEI sites were assessed for CT, symptom severity, and cognitive schemas about self/others. CT was assessed with the Childhood Trauma Questionnaire, and cognitive schemas were assessed by The Brief Core Schema Scale. Results Patients with psychosis were affected by CT more than their siblings and controls in all domains. Childhood emotional abuse and neglect were more common in siblings than controls. CT was related to negative cognitive schemas toward self/others in patients, siblings, and controls. We found that negative schemas about self-mediated the relationship between emotional abuse and thought withdrawal and thought broadcasting. Approximately 33.9% of the variance in these symptoms was explained by the mediator. It also mediated the relationship between sexual abuse and persecutory delusions in SCZ. Conclusions Our findings suggest that childhood abuse and neglect are more common in patients with schizophrenia than their siblings and healthy controls, and have different impacts on clinical domains which we searched. The relationship between CT and positive symptoms seems to be mediated by negative cognitive schemas about self in schizophrenia.

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Prevalence and types of childhood trauma in first episode psychosis patients. Relation with clinical onset variables

Cited by 9 publications

References 68 publications

Examining associations, moderators and mediators between childhood maltreatment, social functioning, and social cognition in psychotic disorders: a systematic review and meta-analysis

Examining associations, moderators and mediators between childhood maltreatment, social functioning, and social cognition in psychotic disorders: a systematic review and meta-analysis

Impact of Childhood Adversity, as Early Life Distress, on Cytokine Alterations in Schizophrenia

The relationship between childhood trauma, psychotic symptoms, and cognitive schemas in patients with schizophrenia, their siblings, and healthy controls: results from the EU-GEI study

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