Prevalence and type of cerebral palsy in a British ethnic community: the role of consanguinity

Sinha, Gyan; Corry, Peter; Subesinghe, D.; Wild, Jennifer; Levene, Malcolm I.

doi:10.1111/j.1469-8749.1997.tb07422.x

Cited by 50 publications

(25 citation statements)

References 17 publications

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“…While most of the conditions so far mentioned are recognised as single-gene autosomal recessive disorders, several other disorders which may or may not have a genetic component are also seen at increased prevalence in UK Pakistani children. For example, except for some rare ataxic syndromes, cerebral palsy is not thought of as having a genetic basis, but a 1997 report from Bradford described both a significantly increased prevalence in Asian children and a positive family history in more than one quarter of these children [43] . Similar findings have been made in Saudi Arabia [44] and Turkey [45] , and Mitchell and Bundey [46] reported on 18 Pakistani patients from 7 families in the English West Midlands, where there seemed to be a familial pattern of cerebral palsy, with a region of homozygosity identified at chromosome 2q24-q25 in 3 of these families [47] .…”

Section: Increased Numbers Of Conditions Not Confirmed As Autosomal Rmentioning

confidence: 99%

Consanguinity and Prevalence Patterns of Inherited Disease in the UK Pakistani Community

Corry

2014

Hum Hered

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Objectives: The aim of this paper is to describe the current knowledge about inherited diseases in UK children of Pakistani origin, who now number over 300,000, and to investigate disease associations with parental consanguinity. Methods: Published data on the overall prevalence of inherited diseases were reviewed in conjunction with published and unpublished information from the city of Bradford where there is a large resident Pakistani community. Results: There is significant literature on infant mortality, congenital anomalies, disabilities and many clinical conditions, often drawing attention to ethnic variations and an increased disease prevalence in UK Pakistani children. A further analysis is frequently necessary to differentiate both between genetic and non-genetic causes, and Pakistani and non-Pakistani children, who collectively have been labelled as ‘Asian' or ‘South Asian'. Conclusions: The analysis suggests that much of the increased mortality and morbidity in UK Pakistani children is due to autosomal recessive conditions. Evidence suggests that this finding is associated with the custom of consanguineous marriage, but future studies might also explore the role of community endogamy. Prevalence data from the first and second post-migration generations could additionally be useful in informing health planning in Pakistan.

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Section: Increased Numbers Of Conditions Not Confirmed As Autosomal Rmentioning

confidence: 99%

Consanguinity and Prevalence Patterns of Inherited Disease in the UK Pakistani Community

Corry

2014

Hum Hered

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“…Clinicians and researchers categorize cerebral palsy into spastic (60–70%), dyskinetic or athetoid (20–30%), and ataxic types (5–10%), in accordance with the muscle tone and format of the movement disorder (predominant abnormality) arising from brain damage2 ) . Since children with cerebral palsy have diverse reflex, muscle tone, and movement patterns3 ) , there is need for the evaluation of the quality of motor activities and method of executing these activities.…”

Section: Introductionmentioning

confidence: 99%

Correlation between the gross motor performance measurement and pediatric balance scale with respect to movement disorder in children with cerebral palsy

Kwon

Ahn

2016

J Phys Ther Sci

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[Purpose] To determine whether the Gross Motor Performance Measurement is useful in predicting the future score of the Pediatric Balance Scale, this study examined the correlation between the 2 measurement tools with respect to movement disorder in children with cerebral palsy. [Subjects and Methods] A total of 38 study subjects with cerebral palsy were divided into 3 groups (spastic, dyskinetic, and ataxic) by means of systematic proportional stratified sampling in accordance with the characteristics of their movement disorders. [Results] The spastic Pediatric Balance Scale had an intermediate level of positive correlation with dissociated movement (r=0.411), alignment (r=0.518), and weight shift (r=0.461). The dyskinetic Pediatric Balance Scale had a strong positive correlation with dissociated movement (r=0.905), coordination (r=0.882), alignment (r=0.930), and stability (r=0.924). The ataxic Pediatric Balance Scale had an intermediate level of positive correlation with the overall Gross Motor Performance Measurement (r=0.636), and a strong positive correlation with dissociated movement (r=0.866), coordination (r=0.871) and stability (r=0.984). [Conclusion] Gross Motor Performance Measurement is important in evaluating the quality of movement, and can be considered an excellent supplementary tool in predicting functional balance.

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“…It was also the second Canadian-based study to accomplish this. All previous studies were based on information gathered from cerebral palsy registries or exhaustive record searches (Al-Rajeh et al, 1991;Nottidge and Okogbo, 1991;Grether et al, 1992;Hagberg et al, 1993;Murphy et al, 1993;Krageloh-Mann et al, 1994;MacGillivray and Campbell, 1995;Meberg and Broch, 1995;Hagberg et al, 1996;Pharoah et al, 1996;Sinha et al, 1997;Topp et al, 1997;Kavcic and Perat, 1998;Pharoah et al, 1998;Robertson et al, 1998;Bottos et al, 1999;Sciberras and Spencer, 1999;Colver et al, 2000;Stanley et al, 2000;Surveillance of Cerebral Palsy in Europe, 2000;Hagberg et al, 2001;Parkes et al, 2001;Topp et al, 2001;Suzuki and Ito, 2002;and Cans et al, 2004).…”

Section: Population-based Record Linkagementioning

confidence: 99%

“…Pharoah et al (1996) agreed that the prevalenee of eerebral palsy among ehildren weighing greater than 2500 grams has remained steady at about 1. In a study conducted by Sinha, Corry, Subesinghe, Wild and Levene (1997), the prevalenee of eerebral palsy was measured in an Asian community that was predominantly Pakistani Muslim, in the northeast of England. Cases of eerebral palsy were identified using the Yorkshire Regional Cerebral Palsy Register.…”

Section: The Epidemiology Of Cerebral Palsymentioning

confidence: 99%

“…Cases of eerebral palsy were identified using the Yorkshire Regional Cerebral Palsy Register. Birth registrations were also recorded by ethnic subgroups, allowing Sinha et al (1997) to determine the prevalenee of eerebral palsy in both the Asian and the non-Asian population within the Bradford District Health Authority (BDHA). The study was conducted between .…”

Section: The Epidemiology Of Cerebral Palsymentioning

confidence: 99%

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The epidemiology of cerebral palsy in British Columbia.

Smith¹

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Prevalence and type of cerebral palsy in a British ethnic community: the role of consanguinity

Cited by 50 publications

References 17 publications

Consanguinity and Prevalence Patterns of Inherited Disease in the UK Pakistani Community

Consanguinity and Prevalence Patterns of Inherited Disease in the UK Pakistani Community

Correlation between the gross motor performance measurement and pediatric balance scale with respect to movement disorder in children with cerebral palsy

The epidemiology of cerebral palsy in British Columbia.

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