Prevalence and Type Distribution of High-Risk Human Papillomavirus (HPV) in Breast Cancer: A Qatar Based Study

Sher, Gulab; Salman, Nadia Aziz; Kuliński, Michał; Fadel, Rayyan Abdulaziz Attya; Gupta, Vinod Kumar; Anand, Ambika; Gehani, Salahddin; Abayazeed, Sheraz; Al‐Yahri, Omer; Shahid, Fakhar; Alshaibani, Salman; Hassan, Sara; Chawdhery, M.Zafar; Davies, Giles; Dermime, Said; Uddin, Shahab; Ashrafi, G. Hossein; Junejo, Kulsoom

doi:10.3390/cancers12061528

Cited by 26 publications

(22 citation statements)

References 30 publications

(35 reference statements)

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“…In the State of Qatar, Sher et al, 2020 [216] examined a cohort of 150 freshly obtained breast tissue specimens (50 benign breast lesions, 50 breast cancer, and 50 normal breast tissues) and reported the presence of high-risk HPV in 10% of the subjects with breast cancer, of which 12.12% were invasive carcinomas [216]. Concomitantly, our group examined 74 cases of breast cancer from 2008 to 2019 that were treated surgically in Hamad General Hospital, Qatar, and detected high-risk HPVs in 65% of the cases with a significant correlation between HPV+ breast cancer and triple-negative breast cancer subtype [217].…”

Section: In Gcc Countries and Yemenmentioning

confidence: 99%

Human Papillomaviruses-Related Cancers: An Update on the Presence and Prevention Strategies in the Middle East and North African Regions

et al. 2022

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The human papillomavirus (HPV) is a non-enveloped double-stranded DNA virus capable of infecting skin and mucosa epithelial cells. Commonly, HPV infection is associated with sexually transmitted diseases and is considered the leading cause of cervical cancer and other carcinomas of the anogenital tract. However, several studies reported their involvement in cancers of non-sexual regions, including colorectal, head and neck, and breast cancers. There are several studies from the Middle East and North Africa (MENA) regions on the potential association between high-risk HPVs and cancer; nevertheless, there are limited studies that address the significance of HPV vaccination as a potential guard against these cancers. In the current review, we present a comprehensive description of the current HPV-associated cancers prevalence rates in the MENA region, demonstrating their steady increase with time, especially in African regions. Moreover, we discuss the potential impact of vaccination against HPV infections and its outcome on human health in this region.

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Section: In Gcc Countries and Yemenmentioning

confidence: 99%

Human Papillomaviruses-Related Cancers: An Update on the Presence and Prevention Strategies in the Middle East and North African Regions

et al. 2022

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“…Various recent studies have revealed the composition of the microbiome in breast cancer tissue. Specifically, the human papillomavirus (HPV) is one of the most common microorganisms present in breast cancers when compared to other normal breast controls [ 60 , 62 , 63 ]. Interestingly, several studies suggest that the HPV might be a critical trigger for breast ductal carcinomas due to its capacity to immortalize resident epithelial cells [ 64 - 66 ].…”

Section: Microbiome: General Facts and Its Role In Cancermentioning

confidence: 99%

The Microbiome-Immune Axis Therapeutic Effects in Cancer Treatments

Son

Kim

2022

J. Microbiol. Biotechnol.

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IntroductionCancer, one of the foremost reasons of deaths throughout the world, is a disease whereby some of body's cells grow uncontrollably and spread to other parts of the body. In 2020, more than 1.8 million new cancer cases were estimated to be diagnosed and around 606,520 of people died in the United States alone [1]. An enormous variety of cancer types have been reported and studied worldwide. The most common in humans are breast, lung, colon, rectum, and prostate cancers. There are several causes for cancer development in humans, including tobacco use, high body mass index, alcohol consumption, unbalance food intake and lack of physical activity [2,3]. Moreover, there are also biological carcinogens, often carried by microorganisms such as viruses, bacteria, or parasites, reported as the major reasons of cancer development [4]. Despite the massive efforts made in the cancer research field and the remarkable progress seen at the clinical level, cancer treatment and prevention are yet intangible. Besides its urgent need for treatment, cancer dynamics are highly related to the understanding of life itself from genetic to ecological perspectives and a better understanding of cancer per se is crucial for greater knowledge of human biology and scientific advancement. However, due to their cardinal feature of evading the immune system, which delay the design of effective anticancer therapeutic strategies, further advancement is needed for current cancer therapies.Regarding cancer persistence, numerous studies have reported that several factors contribute to the tumor persistence in a steady state immune system. The equilibrium and senescence of patients' immune systems are considered two key mechanisms underlying cancer detection during immunological surveillance [5]. Another possible mechanism influencing cancer immune avoidance is likely related to regulatory T (Treg) cell function or their anti-inflammatory cytokine secretions. These cells are responsible for modifying the production of immune suppressive mediators, tolerance and immune deviation [6][7][8][9]. Therefore, it is necessary the development of strategies that enhance immune responses under cancer environments to promote the efficacy of current cancer therapies.Recently, microbiota indicating varied microorganisms such as bacteria, virus, fungi and archaea in most living organisms has been shown to exert great potential in affecting human health and disease, particularly controlling the immune system [10][11][12]. Over the last few decades, the microbiome research field has been rapidly evolving and has become a topic of great scientific and public interest, with the development of remarkable tools, such as During the last decades, research and therapeutic methods in cancer treatment have been evolving. As the results, nowadays, cancer patients are receiving several types of treatments, ranging from chemotherapy and radiation therapy to surgery and immunotherapy. In fact, most cancer patients take a combination of current anti-cancer therapies to i...

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“…Breast cancer (BC) microbiome ( Figure 1 ) is hypothesized to be affected by bacteria-related inflammation in the mammary ducts and glands disrupting the hierarchy of stem cells. Several recent studies focus on the intra-tissue microbial and the viral composition in BC [e.g., human papillomavirus (HPV); Nejman et al, 2020 ; Sher et al, 2020 ]. HPVs are more abundant in BCs compared to benign breast and normal breast controls ( Lawson et al, 2016 ).…”

Section: Breast Intracellular Microbiomementioning

confidence: 99%

“…The effect of HPV on BC has been investigated for years ( Di Lonardo et al, 1992 ; Widschwendter et al, 2004 ; Sher et al, 2020 ). The presence of HPV in BC tissue has resulted in increased histopathological activity in the tumor ( Al-Badry et al, 2019 ).…”

Section: Breast Intracellular Microbiomementioning

confidence: 99%

“…There is a need for further studies that cover a larger and more racially diverse data population, and any findings will provide new insights into the role of the microbiome in the therapy stage and the investigation of novel bacterial biomarkers ( Chiba et al, 2020 ). In summary, the recent developments related to the role of the microbiome in BC reveal the importance of this relationship for the investigation of BC ( Sher et al, 2020 ).…”

Section: Breast Intracellular Microbiomementioning

confidence: 99%

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Tissue Microbiome Associated With Human Diseases by Whole Transcriptome Sequencing and 16S Metagenomics

Salihoğlu

Önal-Süzek

2021

Front. Genet.

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In recent years, a substantial number of tissue microbiome studies have been published, mainly due to the recent improvements in the minimization of microbial contamination during whole transcriptome analysis. Another reason for this trend is due to the capability of next-generation sequencing (NGS) to detect microbiome composition even in low biomass samples. Several recent studies demonstrate a significant role for the tissue microbiome in the development and progression of cancer and other diseases. For example, the increase of the abundance of Proteobacteria in tumor tissues of the breast has been revealed by gene expression analysis. The link between human papillomavirus infection and cervical cancer has been known for some time, but the relationship between the microbiome and breast cancer (BC) is more novel. There are also recent attempts to investigate the possible link between the brain microbiome and the cognitive dysfunction caused by neurological diseases. Such studies pointing to the role of the brain microbiome in Huntington’s disease (HD) and Alzheimer’s disease (AD) suggest that microbial colonization is a risk factor. In this review, we aim to summarize the studies that associate the tissue microbiome, rather than gut microbiome, with cancer and other diseases using whole-transcriptome analysis, along with 16S rRNA analysis. After providing several case studies for each relationship, we will discuss the potential role of transcriptome analysis on the broader portrayal of the pathophysiology of the breast, brain, and vaginal microbiome.

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Prevalence and Type Distribution of High-Risk Human Papillomavirus (HPV) in Breast Cancer: A Qatar Based Study

Cited by 26 publications

References 30 publications

Human Papillomaviruses-Related Cancers: An Update on the Presence and Prevention Strategies in the Middle East and North African Regions

Human Papillomaviruses-Related Cancers: An Update on the Presence and Prevention Strategies in the Middle East and North African Regions

The Microbiome-Immune Axis Therapeutic Effects in Cancer Treatments

Tissue Microbiome Associated With Human Diseases by Whole Transcriptome Sequencing and 16S Metagenomics

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