Prevalence and type distribution of human papillomavirus in healthy Japanese women aged 20 to 25 years old enrolled in a clinical study

Abstract

Efficacy, immunogenicity and tolerability of the human papillomavirus (HPV)‐16/18 AS04‐adjuvanted vaccine were evaluated in Japanese women aged 20–25 years, for which results have been reported previously. We analyzed the baseline data from that study and report the prevalence rates of HPV infection in young healthy Japanese women. One thousand and the forty Japanese women aged 20–25 years were enrolled in a phase II, double‐blind, controlled, randomized, multicenter study. At study entry, cervical specimens were collected from the women and tested by line probe assay for 25 HPV‐types and by HPV‐16/18‐specific polymerase chain reaction. The most frequently detected HPV‐type in baseline cervical specimens was HPV‐52 (8.1%), followed by HPV‐16 (6.5%), HPV‐51 (4.5%), HPV‐18 (4.0%) and HPV‐31 (3.8%). The proportion of HPV DNA‐positive women increased with severity of cytological abnormalities: 26.1% (237/908) in normal cytology, 93.3% (70/75) in low‐grade squamous intraepithelial lesion and 100% (7/7) in high‐grade squamous intraepithelial lesion. The relative contribution of HPV‐16 and HPV‐18 was 4.1 and 3.0% for normal cytology cases, and 20.0 and 16.0% in low‐grade squamous intraepithelial lesion, respectively. HPV‐16 was found in four of seven high‐grade squamous intraepithelial lesion cases (57.1%) and five of the six cervical intraepithelial neoplasia 2+ cases (83.3%). Multiple and single HPV infections were observed in 13.5% (140/1039) and 20.7% (215/1039) of all women, respectively. The HPV prevalence rates in Japanese women aged 20–25 years underline the importance of HPV vaccination at a young age and this report should be useful for monitoring changes in HPV prevalence after widespread HPV vaccination in Japanese women. (Cancer Sci 2011; 102: 877–882)

Development and evaluation of a cervical cancer screening system in Cambodia: A collaborative project of the Cambodian Society of Gynecology and Obstetrics and Japan Society of Obstetrics and Gynecology

“…HPV types 51 and 53 are low‐risk genotypes for development of invasive cancer although these cause squamous intraepithelial lesions. These data were reasonably consistent with those of Japanese females aged 20–25 years . Notably, generation in both factory‐based and hospital‐based program are so young that various low‐risk HPV genotypes can be detected widely in women.…”

Efficacy of the human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine against cervical intraepithelial neoplasia and cervical infection in young Japanese women

“…The baseline characteristics with respect to the age, history of HPV infection and cervical cytology status were similar in the HPV vaccine and the control groups, as described previously (data not shown). 29 , 30 …”

Absence of Human Papillomavirus Infection and Activation of PI3K-AKT Pathway in Cervical Clear Cell Carcinoma

“…In East Asia including Japan, HPV16 and 18 are less frequently identified, and HPV52 and 58 are more common compared with Southeast Asia, North America, and Europe. 22,23 The majority of studies to date were conducted in Europe and North America, and HPV16 and 18 were the most often detected HPV types in CCCC. 18,24,25 In our study, all patients were Japanese, and this rational difference can contribute to HPV testing results.…”