Prevalence and Trends in Alcohol Dependence and Alcohol Use Disorders in Japanese Adults; Results from Periodical Nationwide Surveys

Osaki, Yoneatsu; Kinjo, Aya; Higuchi, Susumu; Matsumoto, Hiroshi; Yuzuriha, Takefumi; Horie, Yoshinori; Kimura, Masashi; Kanda, Hideyuki; Yoshimoto, Hisashi

doi:10.1093/alcalc/agw002

Cited by 79 publications

(72 citation statements)

References 14 publications

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“…Smoking rates remain higher among industrialized countries (32.2% in men and 8.5% in women), and tobacco-related cancers and diseases are (and will be) frequent. Although the prevalence of daily drinking is declining, only a small fraction of alcohol-dependent patients had received medical care [10, 11]. Sedentary working style, physical inactivity, and greater motorization are prevailing [10, 12].…”

Section: Discussionmentioning

confidence: 99%

Life expectancy and healthy life expectancy of Japan: the fastest graying society in the world

2016

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BackgroundWe appraised time trends of Japanese life expectancy (LE) and healthy life expectancy (HALE) by gender, LE-HALE and (LE-HALE)/LE figures, along with the women–men’s differences.MethodsUsing the Japanese LE and HALE values from 1990 through 2013 by gender in the article by the GBD 2013 DALYs and HALE Collaborators, we examined trends of LE and HALE, and their 5- or 3-year changes. We also probed LE-HALE and (LE-HALE)/LE values, and the women–men’s differences.ResultsLE consistently elongated as reported 76.0, 76.5, 77.6, 78.7, 79.3 and 80.1 years for men from 1990 to 2013; and 82.0, 82.8, 84.3, 85.5, 86.1 and 86.4 years for women, respectively. Both time trends demonstrated a significant linear increase (p for trend < 0.001). LE changes were 0.4, 1.1, 1.1, 0.7 and 0.7 years for men, and 0.9, 1.5, 1.2, 0.6 and 0.3 years for women. The trends were statistically significant (p < 0.001), except for 2010–2013 partly due to 3-year interval. HALE also steadily lengthened as seen 68.1, 68.4, 69.1, 69.9, 70.8 and 71.1 years for men from 1990 through 2013; and 72.2, 72.9, 74.0, 74.8, 75.4 and 75.6 years for women. Both time trends showed almost a linear increase (p < 0.05). HALE changes were 0.4, 0.6, 0.8, 0.9 and 0.3 years for men, and 0.7, 1.0, 0.8, 0.6 and 0.2 years for women, without statistical significant trends. LE-HALE values were 8.0, 8.0, 8.5, 8.8, 8.6 and 8.9 years for men; and 9.7, 9.9, 10.4, 10.7, 10.7 and 10.8 years for women. (LE-HALE)/LE figures were 10.5, 10.5, 10.9, 11.1, 10.8 and 11.2% for men, and 11.9, 12.0, 12.3, 12.5, 12.4 and 12.5% for women. LE women–men’s differences were 5.9, 6.4, 6.8, 6.8, 6.8 and 6.3 years, and the HALE figures were 4.2, 4.5, 4.9, 4.9, 4.6 and 4.5 years.ConclusionsLE and HALE consistently linearly elongated for both sexes over the study period. Not only LE-HALE but also (LE-HALE)/LE values were still growing for both sexes. Public health measures, nursing-care/services as well as social security schemes are called for to further elevate longevities, HALE in particular, and enhance quality of life and well-being.

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Section: Discussionmentioning

confidence: 99%

Life expectancy and healthy life expectancy of Japan: the fastest graying society in the world

2016

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“…First, alcohol consumption was measured based on self-reported doses. However, the prevalence of alcohol dependence diagnosed by ICD-10 was reportedly low at 1.9% for men and 0.2% for women in Japanese individuals [35]. In our study, the exclusion criterion of alcoholic consumption was determined by reference to clinical practice guidelines in Japan [4], and we excluded 1714 (6.97%) individuals; therefore, we believe alcohol consumption probably had a negligible impact (if at all) on our results.…”

Section: Limitationsmentioning

confidence: 72%

Frequently abnormal serum gamma-glutamyl transferase activity is associated with future development of fatty liver: a retrospective cohort study

Fujii

Doi

et al. 2020

Preprint

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BackgroundNonalcoholic fatty liver disease is characterized by excessive hepatic fat accumulation. Some individuals frequently present elevated gamma-glutamyl transferase (GGT) levels without fatty liver ultrasound images and other abnormal liver enzymes levels. However, whether these individuals are at an elevated risk for developing fatty liver is unclear. We compared fatty liver change rates and risk factors between individuals with frequently elevated GGT levels and those with normal levels.MethodsWe designed a retrospective cohort study on the basis of complete medical checkup records. One group of individuals had presented normal serum GGT levels during the observation period (Normal-GGT group, n = 2713). Another group had had abnormal elevated serum GGT levels frequently (Abnormal-GGT group, n = 264). We determined the fatty liver change incident rates before and after propensity score matching. We explored confounding factors affecting fatty changes in each group using univariate and multivariate Cox models.ResultsThe change incidence rates were 5.80/1000 and 10.02/1000 person-years in the Normal-GGT and Abnormal-GGT groups, respectively. After propensity score matching, the incidence rates were 3.08/1000 and 10.18/1000 person-years in the Normal-GGT and Abnormal-GGT groups, respectively (p = 0.026). The factors associated with fatty liver changes in the Normal-GGT group included body mass index (BMI), hemoglobin, alanine aminotransferase (ALT), albumin, triglyceride (TG), fasting blood sugar, and high-density lipoprotein levels. Those in the Abnormal-GGT group were platelet counts and TG. In our multivariable analysis, BMI, ALT, albumin, and TG levels were independent predictors of fatty changes in the Normal-GGT group, and high TG level was the only independent predictor in the Abnormal-GGT group.ConclusionsThe incidence rate of fatty liver change in the Abnormal-GGT group was higher than that in the Normal-GGT group. Consecutive elevated GGT levels increase the risk for fatty liver, and high TG levels in those individuals further independently increase the risk.

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“…The United States National Epidemiologic Survey (N = 42 392) showed that the 12‐month prevalence of alcohol dependence was 3.80%, and the lifetime prevalence of alcohol dependence was 12.48% . In Japan, approximately 570 000 adults in the general population of 120 million were classified with alcohol dependence in 2012, making this group one of the largest among the various mental disorders …”

Section: Introductionmentioning

confidence: 99%

“…2 In Japan, approximately 570 000 adults in the general population of 120 million were classified with alcohol dependence in 2012, making this group one of the largest among the various mental disorders. 3 The rewarding effects of addictive substances are mediated by various molecules, and much attention has been given to the effects of G protein-activated inwardly rectifying potassium (GIRK) channels. 4 GIRK channels play an important role in signaling that is influenced by addictive substances.…”

Section: Introductionmentioning

confidence: 99%

A randomized controlled study of the effect of ifenprodil on alcohol use in patients with alcohol dependence

Sugaya

Ogai

Aikawa

et al. 2018

Neuropsychopharm Rep

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Aim: This prospective, randomized, controlled, rater-blinded study investigated the effect of G protein-activated inwardly rectifying potassium (GIRK) channel inhibitor ifenprodil on alcohol use in patients with alcohol dependence. Methods:The participants were 68 outpatients with alcohol dependence who were assigned to an ifenprodil group (administered 60 mg ifenprodil per day for 3 months) or control group (administered 600 mg ascorbic acid and calcium pantothenate per day for 3 months). The participants completed a questionnaire that included the frequency of alcohol drinking and presence of heavy drinking before the study period (time 1) and 3 months after the start of the study period (time 2).The alcohol use score was calculated using these two items.Results: Valid data were obtained from 46 participants (25 in the ifenprodil group and 21 in the control group). The alcohol use score at time 2 in the ifenprodil group was significantly lower than that in the control group after adjusting for the score at time 1 and some covariates. The intention-to-treat analysis of multiply imputed datasets indicated similar results. Group differences in the frequency of alcohol drinking were significant in the multiply imputed datasets but not in 46 participants. The ifenprodil group had a significantly lower rate of heavy drinking at time 2 than the control group.Conclusions: This study found an inhibitory effect of ifenprodil on alcohol use in patients with alcohol dependence. The results support the hypothesis that GIRK channel inhibitors ameliorate alcohol dependence.Trial registry: This trial was registered in the UMIN clinical trial registry (UMIN000006347).alcohol dependence, alcohol use, G protein-activated inwardly rectifying potassium channel, ifenprodil, randomized controlled study Nagisa Sugaya and Yasukazu Ogai contributed equally to this study.This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. The rewarding effects of addictive substances are mediated by various molecules, and much attention has been given to the effects of G protein-activated inwardly rectifying potassium (GIRK) channels. 4 GIRK channels play an important role in signaling that is influ- The opening of GIRK channels hyperpolarizes the cell membrane to modulate neuronal excitability. Ethanol has been found to directly open GIRK channels. [8][9][10] Nucleotide sequence differences in GIRK channel subunit genes have been reportedly related to alcohol dependence and other substance use disorders. Ethanol-induced antinociception is reduced in weaver mutant mice that possess an amino acid sequence mutation of the GIRK2 subunit. 5,8 Hill et al 11 reported that GIRK2 knockout mice exhibited a reduction in saccharin aversion at a nonhypnotic dose of ethanol in a conditioned taste aversion paradigm and weaker ethano...

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Prevalence and Trends in Alcohol Dependence and Alcohol Use Disorders in Japanese Adults; Results from Periodical Nationwide Surveys

Abstract: The survey observed many hidden alcoholic patients, and showed the possibility that the healthcare facilities and health screening became the place of screening and intervention for alcohol dependence.

Cited by 79 publications

References 14 publications

Life expectancy and healthy life expectancy of Japan: the fastest graying society in the world

Life expectancy and healthy life expectancy of Japan: the fastest graying society in the world

Frequently abnormal serum gamma-glutamyl transferase activity is associated with future development of fatty liver: a retrospective cohort study

A randomized controlled study of the effect of ifenprodil on alcohol use in patients with alcohol dependence

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