Prevalence and Treatment of Depression in Children and Adolescents With Sickle Cell Disease

Jerrell, Jeanette M.; Tripathi, Avnish; McIntyre, Roger S.

doi:10.4088/pcc.10m01063

Cited by 44 publications

(71 citation statements)

References 35 publications

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“…2 Darbari and colleagues found that the frequency of vaso-occlusive crises increased with age among adolescents with SCD. 4 Adolescents and young adults with SCD were also found to be at risk for high rates of depression and anxiety, 5,6 with reported depression rates as high as 45% in adolescents 6 and 27.6% in adults. 7 The purpose of this study was to provide a longitudinal description of the clinical characteristics and disease severity among AYAs with SCD during transition from pediatric to adult care.…”

Section: Introductionmentioning

confidence: 99%

Transition to adult care in sickle cell disease: A longitudinal study of clinical characteristics and disease severity

Kayle

Docherty

Sloane

et al. 2018

Pediatric Blood & Cancer

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Background. Sickle cell disease (SCD) is a chronic blood disorder in which mortality has increased for adolescents and young adults (AYA). Procedure. A longitudinal analysis of medical records was conducted to describe the clinical course among AYAs (ages 12–27 years) during transition to adult care. Measures included sociodemographic, complications, SCD severity (modified pediatric SCD severity index), comorbidities, and transfer. Group-based trajectory modeling (GBTM) to identify subgroups with distinct severity trajectories and chi-square and unpaired student t-test to explore subgroup differences were used. Results. Overall, 339 AYAs (97% black, 56% male, 69% hemoglobin SS) had 10848 clinic, 3840 hospital, and 3152 emergency department visits. Complications included vaso-occlusive crises (80%) and acute chest syndrome (41%). Comorbidities included depression (19%) and anxiety (14%). Most AYAs transferred to adult care (n=220) at 19 years. Fourteen AYAs died, 10 within seven years from transfer. GBTM identified both stable and increasing severity trajectory groups: stable-low (n=31, 23%), stable-medium (n= 61, 46%), stable-high (n=6, 5%), low-increasing (n=13,10%), and medium-increasing (n= 22,17%). AYAs with increasing severity (25%) were older, lived closer to the clinic, and had higher risk for SCD complications and comorbidities. They had less pediatric clinic visits, however, they were more likely to transfer and remain longer in adult SCD care. Conclusions: Whereas most AYAs had stable severity, nearly a quarter had increasing severity, over time. AYAs with increasing severity had more complications, were more likely to transfer to adult care, and demonstrated higher and longer adult SCD care utilization compared to AYAs with stable severity.

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Section: Introductionmentioning

confidence: 99%

Transition to adult care in sickle cell disease: A longitudinal study of clinical characteristics and disease severity

Kayle

Docherty

Sloane

et al. 2018

Pediatric Blood & Cancer

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“…Children with sickle cell anemia with or without CVA exhibit a gradual decrease in full-scale IQ (King et al, 2014). Pain episodes triggered by stress, anxiety, mood, sleep disturbances, weather, or physical activity may result in school absences and reduced extracurricular activities, producing decreased levels of participation in adolescent occupations (Herron, Bacak, King, & DeBaun, 2003;Jerrell, Tripathi, & McIntyre, 2011). Decreased cognitive functioning combined with reduced experience with activities of daily living (ADLs) can limit the ability of adolescents with SCD to transition to adult health care and independent living (Treadwell, Telfair, Gibson, Johnson, & Osunkwo, 2011).…”

Section: Negative Effects Of Sickle Cell Disease On Functionmentioning

confidence: 99%

Transition Needs of Adolescents With Sickle Cell Disease

Abel

Cho

Chadwick-Mansker

et al. 2015

The American Journal of Occupational Therapy

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OBJECTIVE. This article describes how adolescents with sickle cell disease (SCD) perceive their ability to perform everyday tasks required for transition to adult health care and independent living. METHOD. The Adolescent Autonomy Checklist (AAC) was adapted to include skills associated with managing SCD (AAC–SCD) and was administered to adolescents during clinic visits. Participants indicated “can do already” or “needs practice” for 100 activities in 12 categories. RESULTS. Of 122 patients, the percentage of adolescents who needed practice was greatest in living arrangements (38.7%), money management (35.8%), vocational skills (29.6%), and health care skills (25.5%). We found a significant effect of age and of cerebrovascular injury on the percentage of those who reported “needs practice” in multiple categories. We found no effect of gender and limited effect of hemoglobin phenotype on any skill category. CONCLUSION. Findings support the need for educational intervention to improve transition skills in adolescents with SCD.

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“…2 Recent work has focused on assessing the prevalence of depression in SCD, understanding the role of depression in other clinical phenomena such as pain, neurocognitive deficits, sleep problems, and health care use, and understanding the interrelationships between depression and social factors such as social functioning and social stigma. 8,10,14,18,20,25,26,28,30,32,33 This work has given little attention to incorporating underlying biological mechanisms into the analysis of the overlap between SCD and depressive symptoms (though see Treadwell et al). 34 Thus, other references related to the biological basis of stress, SCD, and depression have been included here.…”

Section: Resultsmentioning

confidence: 98%

“…2 Recent reviews of the literature in this area have primarily focused on summarizing research findings on prevalence, made general recommendations for treatment, and raised awareness of the need to identify psychiatric disorders that are commonly comorbid with SCD. 2,12,18,21,22 Of note, one study used the transactional stress and coping model to discuss individual and family factors that contribute to depressive symptoms in children with SCD. 21 This model conceptualizes the relationship between chronic illness and adaptation as varying from one person to another and as dependent on biomedical and psychosocial factors.…”

Section: Introductionmentioning

confidence: 99%

Overlapping Biological Mechanisms Underlying Sickle Cell Disease, Stress, and Depression

Katz

Schatz²

2014

Harvard Review of Psychiatry

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After participating in this activity, learners should be better able to:1. Evaluate the overlap between sickle cell disease (SCD) and depression.2. Identify sources of psychological stress and biological vulnerabilities toward developing depression in patients with SCD.3. Assess the potential mechanisms underlying SCD, stress, and depression.Depression is a common co-occurring disorder in persons with sickle-cell disease (SCD). Individuals with this chronic illness may be particularly vulnerable to depression. In addition to risk factors for depression specifically related to SCD, these individuals typically experience further psychological stress due to multiple risk factors in their environment. To date, however, little research has focused on the co-occurring biological mechanisms across these conditions and how those mechanisms may interact to produce depressive symptoms. In this review we use a stress-vulnerability framework to describe the sources of psychological stress and the SCD factors that increase the risk of depression. We suggest that several biological factors, such as nitric oxide and cytokines, may play an important role in co-occurring stress, SCD, and depression. The interaction of these factors may be of particular importance for understanding the comorbidity of SCD and depression. Implications for current treatment and future research are discussed.

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Prevalence and Treatment of Depression in Children and Adolescents With Sickle Cell Disease

Cited by 44 publications

References 35 publications

Transition to adult care in sickle cell disease: A longitudinal study of clinical characteristics and disease severity

Transition to adult care in sickle cell disease: A longitudinal study of clinical characteristics and disease severity

Transition Needs of Adolescents With Sickle Cell Disease

Overlapping Biological Mechanisms Underlying Sickle Cell Disease, Stress, and Depression

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