Prevalence and Transmission of SARS-CoV-2 in Childcare Facilities: A Longitudinal Study

Haag, Luise; Blankenburg, Judith; Unrath, Manja; Grabietz, Johanna; Kahre, Elisabeth; Galow, Lukas; Schneider, Josephine; Dalpke, Alexander H.; Lück, Christian; Büttner, Leo; Berner, Reinhard; Armann, Jakob

doi:10.1101/2021.04.16.21255616

Cited by 3 publications

(2 citation statements)

References 14 publications

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“…day-care, nurseries or schools) using either longitudinal or cross-sectional designs We only included studies which identified SARS-CoV-2 infection through RT-PCR on oral or nasal samples or through established serological methods. We did not include studies which used less well validated methods such as rapid antigen tests, stool samples [21] or wastewater methods.…”

Section: Eligibilitymentioning

confidence: 99%

Transmission of SARS-CoV-2 by Children and Young People in Households and Schools: A Meta-Analysis of Population-Based and Contact-Tracing Studies

et al. 2021

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Section: Eligibilitymentioning

confidence: 99%

Transmission of SARS-CoV-2 by Children and Young People in Households and Schools: A Meta-Analysis of Population-Based and Contact-Tracing Studies

et al. 2021

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“…We only included studies which identified SARS-CoV-2 infection through RT-PCR on oral or nasal samples or through established serological methods. We did not include studies which used less well validated methods such as rapid antigen tests, stool samples [21] or wastewater methods.…”

Section: Eligibilitymentioning

confidence: 99%

Transmission of SARS-CoV-2 by children and young people in households and schools: a meta-analysis of population-based and contact-tracing studies

Viner

Waddington

Mytton

et al. 2021

Preprint

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BackgroundThe role of children and young people (CYP) in transmission of SARS-CoV-2 in household and educational settings remains unclear. We undertook a systematic review and meta-analysis of contact-tracing and population-based studies at low risk of bias.MethodsWe searched 4 electronic databases on 28 July 2021 for contact-tracing studies and population-based studies informative about transmission of SARS-CoV-2 from 0-19 year olds in household or educational settings. We excluded studies at high risk of bias, including from under-ascertainment of asymptomatic infections. We undertook multilevel random effects meta-analyses of secondary attack rates (SAR: contact-tracing studies) and school infection prevalence, and used meta-regression to examine the impact of community SARS-CoV-2 incidence on school infection prevalence.Findings4529 abstracts were reviewed, resulting in 37 included studies (16 contact-tracing; 19 population studies; 2 mixed studies). The pooled relative transmissibility of CYP compared with adults was 0.92 (0.68, 1.26) in adjusted household studies. The pooled SAR from CYP was lower (p=0.002) in school studies 0.7% (0.2, 2.7) than household studies (7.6% (3.6, 15.9). There was no difference in SAR from CYP to child or adult contacts. School population studies showed some evidence of clustering in classes within schools. School infection prevalence was associated with contemporary community 14-day incidence (OR 1.003 (1.001, 1.004), p<0.001).InterpretationWe found no difference in transmission of SARS-CoV-2 from CYP compared with adults within household settings. SAR were markedly lower in school compared with household settings, suggesting that household transmission is more important than school transmission in this pandemic. School infection prevalence was associated with community infection incidence, supporting hypotheses that school infections broadly reflect community infections. These findings are important for guiding policy decisions on shielding, vaccination school and operations during the pandemic.FundingNo funding obtained.

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Transmission of SARS-CoV-2 by children and young people in households and schools: A meta-analysis of population-based and contact-tracing studies

Viner

Waddington

Mytton

et al. 2022

Journal of Infection

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Background The role of children and young people (CYP) in transmission of SARS-CoV-2 in household and educational settings remains unclear. We undertook a systematic review and meta-analysis of contact-tracing and population-based studies at low risk of bias. Methods We searched 4 electronic databases on 28 July 2021 for contact-tracing studies and population-based studies informative about transmission of SARS-CoV-2 from 0-19 year olds in household or educational settings. We excluded studies at high risk of bias, including from under-ascertainment of asymptomatic infections. We undertook multilevel random effects meta-analyses of secondary attack rates (SAR: contact-tracing studies) and school infection prevalence, and used meta-regression to examine the impact of community SARS-CoV-2 incidence on school infection prevalence. Findings 4529 abstracts were reviewed, resulting in 37 included studies (16 contact-tracing; 19 population studies; 2 mixed studies). The pooled relative transmissibility of CYP compared with adults was 0.92 (0.68, 1.26) in adjusted household studies. The pooled SAR from CYP was lower (p=0.002) in school studies 0.7% (0.2, 2.7) than household studies (7.6% (3.6, 15.9) . There was no difference in SAR from CYP to child or adult contacts. School population studies showed some evidence of clustering in classes within schools. School infection prevalence was associated with contemporary community 14-day incidence (OR 1.003 (1.001, 1.004), p<0.001). Interpretation We found no difference in transmission of SARS-CoV-2 from CYP compared with adults within household settings. SAR were markedly lower in school compared with household settings, suggesting that household transmission is more important than school transmission in this pandemic. School infection prevalence was associated with community infection incidence, supporting hypotheses that school infections broadly reflect community infections. These findings are important for guiding policy decisions on shielding, vaccination school and operations during the pandemic.

show abstract

Prevalence and Transmission of SARS-CoV-2 in Childcare Facilities: A Longitudinal Study

Cited by 3 publications

References 14 publications

Transmission of SARS-CoV-2 by Children and Young People in Households and Schools: A Meta-Analysis of Population-Based and Contact-Tracing Studies

Transmission of SARS-CoV-2 by Children and Young People in Households and Schools: A Meta-Analysis of Population-Based and Contact-Tracing Studies

Transmission of SARS-CoV-2 by children and young people in households and schools: a meta-analysis of population-based and contact-tracing studies

Transmission of SARS-CoV-2 by children and young people in households and schools: A meta-analysis of population-based and contact-tracing studies

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