Prevalence and status of Lipoprotein (a) among Lebanese school children

Gannagé‐Yared, Marie‐Hélène; Lahoud, Christina; Younes, Nada; Chedid, Rima; Sleilaty, Ghassan

doi:10.1038/s41598-020-77689-5

Cited by 7 publications

(8 citation statements)

References 31 publications

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“…The population included in this study is a subgroup of our initial cohort. In our previous cross-sectional reports, 969 school children aged 8 to 18 years were recruited from 10 different private and public Lebanese schools using a stratified random sampling [23,44]. The schools were selected in the Greater Beirut and Mount Lebanon regions, where most of the Lebanese population is concentrated.…”

Section: Populationmentioning

confidence: 99%

“…BMI for sex and age below the 85th percentile was classified as normal, overweight was defined as BMI for sex and age between the 85th and 95th percentile, and obesity was defined as BMI for sex and age over the 95th percentile [45]. The population was categorized into three age groups: 8-11 years, 12-14 years, and 15-18 years as performed in our previous publications [23,44].…”

Section: Populationmentioning

confidence: 99%

“…The Lp(a) measurement was performed using an immunoturbidimetric assay (Cobas Integra 400 plus system, Roche Diagnostics, Basel, Switzerland) as previously described [44]. In this procedure, human Lp(a) agglutinates with latex particles coated with anti-Lp(a) antibodies.…”

Section: Lipoprotein (A)mentioning

confidence: 99%

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Circulating PCSK9 Linked to Dyslipidemia in Lebanese Schoolchildren

et al. 2022

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In adults, elevated levels of circulating Proprotein Convertase Subtilisin/Kexin type 9 (PCSK9) have been associated with increased Low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), and worse cardiovascular outcomes. However, few studies analyzed the relation between PCSK9 and lipid parameters in pediatric populations. The aim of our study is to evaluate the distribution and the correlation of serum PCSK9 levels with lipid parameters in a sample of Lebanese school children. Using an immunofluorescence assay, we measured serum PCSK9 levels in 681 school children recruited from ten public and private Lebanese schools. We analyzed the association between PCSK9 and age, sex, Body Mass Index (BMI), and lipid parameters (total cholesterol (TC), LDL-C, TG, High-density lipoprotein cholesterol (HDL-C), non-HDL-C, and lipoprotein (a) (Lp(a)). Serum PCSK9 levels were significantly correlated with TC, LDL-C, and non-HDL-C (p value < 0.0001) but not with TG, HDL-C, and Lp(a). PCSK9 levels were also significantly higher in children with high TC, LDL-C, and non-HDL-C (p values = 0.0012, 0.0002, 0.001, respectively). No significant gender differences in PCSK9 were found. In addition, no significant associations between PCSK9 and both age and BMI percentiles were observed. In girls, no difference in PCSK9 values was observed according to menarche while in boys, testosterone levels were not significantly associated with PCSK9. Serum PCSK9 levels were significantly correlated with TC, LDL-C, and non-HDL-C levels. Further studies are needed to find if PCSK9 measurements have an additional value to predict future cardiovascular outcomes in pediatric populations.

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Section: Populationmentioning

confidence: 99%

Section: Populationmentioning

confidence: 99%

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Circulating PCSK9 Linked to Dyslipidemia in Lebanese Schoolchildren

et al. 2022

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“…The Middle East is also a part of the world where dyslipidemia is highly prevalent [ 23 ]. In Lebanon, few cross-sectional studies looked at this prevalence in adult [ 24 , 25 ] or pediatric populations [ 26 , 27 ]. A single study published in 1999 on a population of a tertiary hospital staff found that the respective prevalence of high LDL-C levels and Lp(a) were 27% and 20% [ 24 ].…”

Section: Introductionmentioning

confidence: 99%

“…A single study published in 1999 on a population of a tertiary hospital staff found that the respective prevalence of high LDL-C levels and Lp(a) were 27% and 20% [ 24 ]. In Lebanese children, the prevalence of high non-HDL-C and TG are, respectively, 9.2% and 26.6% [ 26 ], and the prevalence of high Lp(a) is 14.4% [ 27 ]. No other studies have evaluated the lipid profile (TC, HDL-C, TG, Lp(a), and PCSK9) in the Lebanese adult population and its relation to gender, age, and BMI.…”

Section: Introductionmentioning

confidence: 99%

Lipid Parameters and Proprotein Convertase Subtilisin/Kexin Type 9 in Healthy Lebanese Adults

et al. 2022

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Background: High levels of non-HDL cholesterol (non-HDL-C), triglycerides (TG), lipoprotein (a) (Lp(a)), and Proprotein convertase subtilisin/kexin type 9 (PCSK9) as well as low levels of HDL-C are strongly associated with cardiovascular disease (CVD). Our study aims to estimate the prevalence of dyslipidemia and high Lp(a) in the Lebanese population and to study the relationship of these variables with gender, age, body mass index (BMI), and PCSK9. Methods: This cross-sectional study was carried out on a sample of healthy volunteers aged 18 to 65. Blood samples were drawn from volunteers for total cholesterol (TC), HDL-C, TG, PCSK9, and Lp(a) measurements. Non-HDL-C was calculated by subtracting HDL-C from TC. Results: In total, 303 volunteer subjects with an average age of 38.9 years were included in the study. Respectively, 44%, 29.8%, and 44% of men had high non-HDL-C and TG with low HDL-C versus 23.5%, 8%, and 37% in women. Non-HDL-C and TG were significantly higher in men than in women, while the reverse was observed for HDL-C (p < 0.0001 for the three comparisons). Non-HDL-C and TG were significantly correlated with age and BMI (p< 0.0001 for all correlations), while HDL-C was inversely correlated with BMI (p < 0.0001) but not with age. Abnormal Lp(a) levels (≥75 nmol/L) were found in 19.1% of the population, predominantly in women (24.1% versus 13.4% in men, p = 0.004). The median PCSK9 and its interquartile was 300 (254–382) ng/L with no gender difference (p = 0.18). None of the following factors: gender, age, BMI, non-HDL-C, HDL-C, or TG, were independently associated with Lp(a), while PCSK9 was significantly correlated with age, non-HDL-C, and TG in both men and women and inversely correlated with HDL-C in men. Dyslipidemia is very common in the Lebanese population and is associated with age, high BMI, and male sex. Lp(a) is higher in women without any correlation with the lipid profile, whereas PCSK9 is associated with non-HDL-C and TG. Further studies are needed to evaluate the potential role of Lp(a) and PCSK9 in predicting CVD in healthy populations.

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Lipoprotein(a) serum concentrations in children in relation to body mass index, age and sex

Stürzebecher,

Uttinger,

Vogel

et al. 2024

Pediatr Res

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Background Lipoprotein(a) (Lp(a)) is an inherited risk factor for atherosclerotic cardiovascular disease (ASCVD). Limited data exist on Lp(a) values in children. We aimed to evaluate whether Lp(a) concentrations in youth are influenced by BMI. Methods 756 blood samples of 248 children with obesity and 264 matched healthy children aged 5 and 18 years, enrolled in the population-based LIFE Child (German civilization diseases cohort) study, were analyzed. Repeat measurements were available in 154 children (1–4 follow ups, ~1 year apart). Results The median Lp(a) concentration in the total cohort (n = 512) at first visit was 9.7 mg/dL (IQR 4.0–28.3). Lp(a) concentrations between 30–50 mg/dL were observed in 11.5%, while 12.5% exhibited Lp(a) ≧50 mg/dL. There was no association of Lp(a) with body mass index (BMI) (ß = 0.004, P = 0.49). Lp(a) levels did not correlate with age or sex, while Lp(a) was associated positively with low-density lipoprotein cholesterol (ß = 0.05, P < 0.0001). The Lp(a) risk category remained stable in 94% of all children in repeated measurements. Conclusions The data showed no association of Lp(a) levels in children with BMI, age or sex. Measurement of Lp(a) in youth may be useful to identify children at increased lifetime risk for ASCVD. Impact In youth, Lp(a) levels are not affected by age, sex and BMI. Lp(a) risk categories remain stable over time in repeated measurements in children. Measurement of Lp(a) in children may be useful as an additional factor to identify children at increased lifetime risk for ASCVD and for reverse family screening.

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Prevalence and status of Lipoprotein (a) among Lebanese school children

Cited by 7 publications

References 31 publications

Circulating PCSK9 Linked to Dyslipidemia in Lebanese Schoolchildren

Circulating PCSK9 Linked to Dyslipidemia in Lebanese Schoolchildren

Lipid Parameters and Proprotein Convertase Subtilisin/Kexin Type 9 in Healthy Lebanese Adults

Lipoprotein(a) serum concentrations in children in relation to body mass index, age and sex

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