Prevalence and Significant Determinants of Post-traumatic Stress Disorder in a Large Sample of Patients with Multiple Sclerosis

Ostacoli, Luca; Carletto, Sara; Borghi, Martina; Cavallo, Marco; Rocci, Emanuela; Zuffranieri, Marco; Malucchi, Simona; Bertolotto, Antonio; Zennaro, Alessandro; Furlan, Pier Maria; Picci, Rocco Luigi

doi:10.1007/s10880-012-9323-2

Cited by 23 publications

(15 citation statements)

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“…Several neurological and neuropsychiatric conditions, such as Parkinson's disease, multiple sclerosis and dementias are typically characterized by important deficits that reduce significantly patients' skills and their overall quality of life (Enrici et al, 2015;Ostacoli et al, 2013;Cavallo et al, 2011). Amongst them, Alzheimer's disease (AD) is the most common form of dementia, and it accounts for an estimated 60-80% of all cases.…”

Section: Introductionmentioning

confidence: 99%

Computerized Structured Cognitive Training in Patients Affected by Early-Stage Alzheimer's Disease is Feasible and Effective: A Randomized Controlled Study

Cavallo

Hunter

Hiele

et al. 2016

Arch Clin Neuropsychol

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Section: Introductionmentioning

confidence: 99%

Computerized Structured Cognitive Training in Patients Affected by Early-Stage Alzheimer's Disease is Feasible and Effective: A Randomized Controlled Study

Cavallo

Hunter

Hiele

et al. 2016

Arch Clin Neuropsychol

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“…Previous studies have focused on the psychosocial impact of MS, showing a high prevalence of depression, anxiety and a reduced Quality of Life (QoL) [ 1 – 6 ]. Depression affects from 15 to 47 % of patients [ 7 , 8 ], with lifetime prevalence estimates at 50 % [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

The efficacy of a Mindfulness Based Intervention for depressive symptoms in patients with Multiple Sclerosis and their caregivers: study protocol for a randomized controlled clinical trial

et al. 2016

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BackgroundMultiple Sclerosis has a great impact on psychological functioning of patients and can be associated with various mental health disorders and symptoms. The most prevalent one is depression, which ranges from 15 to 47 %.Mindfulness Based Interventions are a relatively brief and cost-effective program that has been studied in patients with several chronic diseases and recently also in patients with Multiple Sclerosis. Mindfulness Based Interventions are based on the assumption that a non-judgmental awareness and acceptance of one’s moment-to-moment experience can have a positive effect on the adaptation to the disease, reducing the psychological burden and improving patients’ quality of life.Several studies concluded that Mindfulness Based Interventions can be beneficial in terms of improving both psychological and psychical aspects of Multiple Sclerosis, but none of them compared the intervention with an active control group. The primary objective of the study is to evaluate the efficacy of a group-based Mindfulness Based Intervention on depressive symptoms in patients with Multiple Sclerosis, as compared with an active control group.MethodsThe study design is a randomized controlled clinical trial. Eighty-eight patients with Multiple Sclerosis and depressive symptoms will be recruited and randomized to either Mindfulness Based Intervention or an active control group. The latter is designed to control for non-specific elements of the intervention and it comprises psycho-education and relaxation techniques. The primary outcome is the reduction of depressive symptoms as measured via the Beck Depressive Inventory-II. Secondary outcome measures are level of quality of life, anxiety, perceived stress, illness perception, fatigue and quality of interpersonal relationship. Outcomes will be assessed at baseline, after treatment and 6 months after the end of the treatment. Caregivers will participate in groups together with patients.DiscussionAs far as we know this trial will be the first randomized controlled trial testing the efficacy of group-based Mindfulness Based Intervention for patients with Multiple Sclerosis with a comparison with an active control group with a specific focus on depressive symptoms.Trial registrationNCT02611401.

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“…Depressive symptoms have been reported to occur in figures that range from 15 % to above 50 % of PwMS [ 17 – 22 ]. In addition to depression, variant forms of anxiety disorders have been reported to be common among PwMS [ 23 – 25 ]. Korostil and Feinstein [ 26 ] examine the presence of anxiety among 140 consecutive clinic attendees using the Structured Clinical Interview, as well as the Hospital Anxiety and Depression (HADS) ‘symptoms checklist’.…”

Section: Introductionmentioning

confidence: 99%

Magnitude and concurrence of anxiety and depression among attendees with multiple sclerosis at a tertiary care Hospital in Oman

et al. 2015

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BackgroundAnxiety, depression and functional impairments are commonly reported by persons with multiple sclerosis (PwMS) but no data, to our knowledge, has emerged from an Arab Islamic population. The study aims to investigate the prevalence of anxiety, depression and related disabilities among PwMS attending tertiary care in Sultan Qaboos University Hospital (SQUH), one of the urban hospitals in Oman.MethodsConsecutive and consenting PwMS (n = 57) and healthy subjects (n = 53) completed the following measures: Hospital Anxiety and Depression Scale (HADS) which was used to measure anxiety (cut-point >7) and depression (>7); and Expanded Disability Status Scale (EDSS) to measure the level of disability (≥5). Characteristics such as socio-demographic and clinical variables were also explored.ResultsFifty seven subjects with multiple sclerosis (MS) met the inclusion criteria. The majority of them were females who were 40 years old or younger and the majority were employed and unmarried. Approximately 86 % of the participants were using beta interferon, 96 % scored ≥5 in EDSS. MS of the Relapsing-Remitting type constituted the majority of the cohort (94 %). Approximately 35 % and 51 % endorsed symptoms of anxiety and depression respectively. The MS group scored significantly higher than controls on HADS measurements of depression and anxiety.ConclusionDisability and symptoms of anxiety and depression are common among the PwMS attendees of tertiary care hospital in Oman. Such psychosocial variables have been largely unreported emerging from non-western populations. As these variables are strong indicators of the burden of MS, resolute effort is needed to address such psychosocial dysfunctions in the algorithms of care for PwMS in the Arab Islamic part of the world.

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Prevalence and Significant Determinants of Post-traumatic Stress Disorder in a Large Sample of Patients with Multiple Sclerosis

Cited by 23 publications

References 34 publications

Computerized Structured Cognitive Training in Patients Affected by Early-Stage Alzheimer's Disease is Feasible and Effective: A Randomized Controlled Study

Computerized Structured Cognitive Training in Patients Affected by Early-Stage Alzheimer's Disease is Feasible and Effective: A Randomized Controlled Study

The efficacy of a Mindfulness Based Intervention for depressive symptoms in patients with Multiple Sclerosis and their caregivers: study protocol for a randomized controlled clinical trial

Magnitude and concurrence of anxiety and depression among attendees with multiple sclerosis at a tertiary care Hospital in Oman

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