Prevalence and seasonal variation of hypovitaminosis D and its relationship to bone metabolism in healthy Hungarian men over 50 years of age: the HunMen Study

Bhattoa, Harjit Pal; Nagy, Endre; Móré, Csaba; Kappelmayer, János; Balogh, Á.; Kalina, Edit; Antal‐Szalmás, Péter

doi:10.1007/s00198-012-1920-2

Cited by 42 publications

(39 citation statements)

References 36 publications

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“…In our study, positive relationships were obtained between 25(OH)D status and BMD at all sites and such relationships persisted after adjustment for age, BMI, serum creatinine and calcium supplementation. Using the FRAX index, we demonstrated that low serum 25(OH)D levels were associated with a high 10-year probability of a hip fracture and a major osteoporotic fracture, which was a finding that was consistent with a previous report in healthy Hungarian men [37]. Supplementation with 800 IU vitamin D 3 and 1,200 mg calcium daily for 3 years reduced the risk of hip fracture by 43% and that of non-vertebral fracture by 32% [38].…”

Section: Discussionsupporting

confidence: 80%

Vitamin D Status and Its Relationship with Body Composition, Bone Mineral Density and Fracture Risk in Urban Central South Chinese Postmenopausal Women

Li¹,

Zhang³

et al. 2014

Ann Nutr Metab

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Aims: This study was designed to assess vitamin D (25(OH)D) status and its relationship with bone mineral density (BMD) and fracture risk, which was determined using the FRAX algorithm, among postmenopausal central south Chinese women, and to identify the risk factors for vitamin D deficiency and osteoporosis. Methods: This cross-sectional study involved 578 healthy postmenopausal central south Chinese women. Fat mass and BMD at lumbar spine (L1-L4), femur neck and total hip were measured with dual X-ray absorptiometry. Serum levels of 25(OH)D, parathyroid hormone and creatinine were measured. The 10-year probabilities of hip and major osteoporotic fracture were calculated by the FRAX model. Results: Approximately 72.1% women were vitamin D deficient (25(OH)D <50 nmol/l). Serum 25(OH)D levels did not correlate with body mass index (BMI), fat mass and weight. They positively correlated with all BMDs (p < 0.05) and negatively correlated with both 10-year fracture probabilities (p < 0.05). BMI ≤19 and age ≥65 years were risk factors for osteoporosis at all sites. Conclusions: Vitamin D deficiency was prevalent among postmenopausal central south Chinese women. Serum 25(OH)D levels were correlated with all BMDs and negatively correlated with both 10-year fracture probabilities.

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Section: Discussionsupporting

confidence: 80%

Vitamin D Status and Its Relationship with Body Composition, Bone Mineral Density and Fracture Risk in Urban Central South Chinese Postmenopausal Women

Li¹,

Zhang³

et al. 2014

Ann Nutr Metab

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“…[2][3][4][5][6][7] Vitamin D exists in two forms: vitamin D2 or ergocalciferol which is found naturally in foods of plant origin, and vitamin D3 or cholecalciferol which is mainly synthesized in the skin by exposure to ultraviolet-B light and is also abundant in foods of animal origin. The main source of vitamin D is via exposure of the human skin to sunlight between 10am and 3pm in the spring, summer and fall.…”

Section: Introductionmentioning

confidence: 99%

Smoking is a significant determinant of low serum vitamin D in young and middle-aged healthy males

Kassi¹,

Stavropoulos²,

Kokkoris³

et al. 2014

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“…Bhattoa és mtsai 50 év feletti egészséges férfiak D-vitamin-státu-szát vizsgálták és vetették össze a FRAX ® -értékekkel [20]. Egy másik vizsgálatban diabeteses betegek körében mérték fel a törési rizikót [21].…”

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A szakellátásban megjelenő osteoporosisos nők 10 éves csonttöréskockázata a FRAX^® alapján

et al. 2016

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Bevezetés: Az osteoporosis-ellátás kulcskérdése a fokozott csonttörési kockázatú betegek azonosítása és kezelése. Cél-kitűzés: A hazai osteoporosis-szakellátásban megjelenő osteoporosisos nők törési kockázatának felmérése. Módszer: A szerzők keresztmetszeti kérdőíves vizsgálatot végeztek 2009-ben 11 osteoporosis-centrumban ≥50 éves osteoporosisos nőbetegek körében. Felmérték a főbb törési kockázati tényezőket, a FRAX ® kalkulátor magyarországi válto-zatával kiszámolták a 10 éves törési kockázatot. Az egészségi állapotot EQ VAS-sal vizsgálták. Eredmények: Az 1301 beteg átlagéletkora 68,5 (SD = 8,3) év, az EQ VAS 62,0 (SD = 17,2) volt, 690 (53%) betegnek volt már törése. A major osteoporosisos törési és a csípőtörési FRAX ® átlagosan 20,1 (SD = 13,9), illetve 10,6 (SD = 12,5) volt (10 éves korcsoportonkénti átlagok: 18,5/9,3; 16,2/6,7; 23,0/13,5; 28,9/18,3). A törésen átesettek értékei szignifikánsan magasabbak voltak (p<0,05). Következtetések: Megközelítően azonos a primer és szekunder törésprevenci-ós kezelésre járó betegek aránya. Az osteoporosis miatt gondozásban részesülők major osteoporoticus törési FRAX Ten-year fracture risk by FRAX ® of women with osteoporosis attending osteoporosis care in HungaryIntroduction: Identification of patients with high fracture risk is a key-point in osteoporosis care. Aim: To assess the fracture risk among osteoporotic women attending osteoporosis care in Hungary. Method: A cross-sectional survey was conducted in 2009 in 11 centres among women with osteoporosis aged ≥50 years. Main risk factors were recorded and 10-year fracture risk was calculated using the FRAX ® for Hungary. Health status was assessed by EQ VAS. Results: 1301 patients with mean age of 68.5 (SD = 8.3) years and EQ VAS of 62.0 (SD = 17.2) participated, of whom 690 (53.0%) have already had previous fracture. Major osteoporotic and hip fracture FRAX ® scores were 20.1 (SD = 13.9) and 10.6 (SD = 12.5), respectively (by 10-year age groups, mean: 18.5/9.3; 16.2/6.7; 23/13.5; 28.9/18.3). Patients with previous fracture had significantly higher scores (p<0.05). Conclusions: Similar rate of patients attend osteoporosis care for primary and secondary prevention. FRAX ® score was higher than 7% in the majority of patients. The findings provide inputs for cost-effectiveness analyses and development of intervention thresholds in Hungary.

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Prevalence and seasonal variation of hypovitaminosis D and its relationship to bone metabolism in healthy Hungarian men over 50 years of age: the HunMen Study

Abstract: A high prevalence of hypovitaminosis D and low BMD were observed in the studied Hungarian male population. This is the first study reporting higher 10-year hip and major osteoporotic fracture probability using the country-specific FRAX algorithm in individuals with hypovitaminosis D.

Cited by 42 publications

References 36 publications

Vitamin D Status and Its Relationship with Body Composition, Bone Mineral Density and Fracture Risk in Urban Central South Chinese Postmenopausal Women

Vitamin D Status and Its Relationship with Body Composition, Bone Mineral Density and Fracture Risk in Urban Central South Chinese Postmenopausal Women

Smoking is a significant determinant of low serum vitamin D in young and middle-aged healthy males

A szakellátásban megjelenő osteoporosisos nők 10 éves csonttöréskockázata a FRAX^® alapján

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Prevalence and seasonal variation of hypovitaminosis D and its relationship to bone metabolism in healthy Hungarian men over 50 years of age: the HunMen Study

Abstract: A high prevalence of hypovitaminosis D and low BMD were observed in the studied Hungarian male population. This is the first study reporting higher 10-year hip and major osteoporotic fracture probability using the country-specific FRAX algorithm in individuals with hypovitaminosis D.

Cited by 42 publications

References 36 publications

Vitamin D Status and Its Relationship with Body Composition, Bone Mineral Density and Fracture Risk in Urban Central South Chinese Postmenopausal Women

Vitamin D Status and Its Relationship with Body Composition, Bone Mineral Density and Fracture Risk in Urban Central South Chinese Postmenopausal Women

Smoking is a significant determinant of low serum vitamin D in young and middle-aged healthy males

A szakellátásban megjelenő osteoporosisos nők 10 éves csonttöréskockázata a FRAX® alapján

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A szakellátásban megjelenő osteoporosisos nők 10 éves csonttöréskockázata a FRAX^® alapján