Prevalence and risk factors of <i>Helicobacter pylori</i> infection in Wuwei, a high‐risk area for gastric cancer in northwest China: An all‐ages population‐based cross‐sectional study

Wang, Xiaofeng; Shu, Xiaochuang; Li, Qiang; Li, Youpeng; Chen, Zhaofeng; Wang, Yuping; Pu, Ke; Zheng, Ya; Ye, Yuwei; Lee, Min; Ma, Lulin; Zhang, Zhiyi; Wu, Zhengqi; Zhang, Fuhua; Guo, Qinghong; Ji, Rui; Zhou, Yongning

doi:10.1111/hel.12810

Cited by 16 publications

(19 citation statements)

References 42 publications

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“…Annual household income, history of smoking, history of alcohol consumption, dining location, and family history of gastric disease or GC were not different between the infected and non-infected groups, but individuals with a higher education level showed a lower infection rate. A 2020 all-ages population-based cross-sectional study[ 28 ] in Wuwei county in northwestern China showed that the prevalence of H. pylori infection was closely associated with socioeconomic conditions, sanitary situations, dietary habits of the participants in the city. Boarding, eating at school, and drinking untreated water were main factors explaining the rising infection rate in junior-senior high school students.…”

Section: Discussionmentioning

confidence: 99%

Family-based Helicobacter pylori infection status and transmission pattern in central China, and its clinical implications for related disease prevention

Yu¹,

Shao²,

Jing³

et al. 2022

WJG

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BACKGROUND Helicobacter pylori ( H. pylori ) has characteristics of family cluster infection; however, its family-based infection status, related factors, and transmission pattern in central China, a high-risk area for H. pylori infection and gastric cancer, have not been evaluated. We investigated family-based H. pylori infection in healthy households to understand its infection status, related factors, and patterns of transmission for related disease prevention. AIM To investigate family-based H. pylori infection status, related factors, and patterns of transmission in healthy households for related disease prevention. METHODS Blood samples and survey questionnaires were collected from 282 families including 772 individuals. The recruited families were from 10 selected communities in the greater Zhengzhou area with different living standards, and the family members’ general data, H. pylori infection status, related factors, and transmission pattern were analyzed. H. pylori infection was confirmed primarily by serum H. pylori antibody arrays; if patients previously underwent H. pylori eradication therapy, an additional 13 C-urea breath test was performed to obtain their current infection status. Serum gastrin and pepsinogens (PGs) were also analyzed. RESULTS Among the 772 individuals examined, H. pylori infection rate was 54.27%. These infected individuals were from 246 families, accounting for 87.23% of all 282 families examined, and 34.55% of these families were infected by the same strains. In 27.24% of infected families, all members were infected, and 68.66% of them were infected with type I strains. Among the 244 families that included both husband and wife, spouse co-infection rate was 34.84%, and in only 17.21% of these spouses, none were infected. The infection rate increased with duration of marriage, but annual household income, history of smoking, history of alcohol consumption, dining location, presence of gastrointestinal symptoms, and family history of gastric disease or GC did not affect infection rates; however, individuals who had a higher education level showed lower infection rates. The levels of gastrin-17, PGI, and PGII were significantly higher, and PGI/II ratio was significantly lower in H. pylori -infected groups than in H. pylori -negative groups. CONCLUSION In our study sample from the general public of central China, H. pylori infection rate was 54.27%, but in 87.23% of healthy households, there was at least 1 H. pylori -infected person; in 27.24% of these infected fami...

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Section: Discussionmentioning

confidence: 99%

Family-based Helicobacter pylori infection status and transmission pattern in central China, and its clinical implications for related disease prevention

Yu¹,

Shao²,

Jing³

et al. 2022

WJG

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“… 1 , 2 The prevalence of HP infection has been reported to increase with age, gradually increasing from 0 to 39 years, peaking at 39 years (59.3%) and gradually decreasing after 60 years. 3 HP was recognized as a group I human carcinogen by the World Health Organization’s International Agency for Research on Cancer. About 50% of gastric cancers are associated with HP.…”

Section: Introductionmentioning

confidence: 99%

Helicobacter pylori Infection as a Risk Factor for Abnormal Serum Protein Levels in General Population of China

Li¹,

Qin²,

Yang³

et al. 2022

JIR

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Background Helicobacter pylori (HP) infection is considered as a risk factor for nutritional and metabolic abnormalities, and serum protein is an important marker of the nutritional and immune status. It is still unknown whether HP infection affects serum protein levels. Methods The participants who underwent health screening from July 2020 to August 2021 were included, among whom, 1485 subjects with 14C-urea breath test (14C-UBT) values ≥100 disintegrations per minute (dpm) were defined as HP-positive cases, and 4864 cases with 14C-UBT values <100 dpm were defined as HP-negative cases. Anthropometric measurements were taken, and biochemical parameters of the blood were analyzed for all subjects. Categorical variables were compared using the χ2 test and continuous variables using Student’s t test. Logistic regression analysis was used to determine the effect of HP infection on serum proteins. Results Age, the proportion of female, globulin levels, total cholesterol levels, and low-density lipoprotein cholesterol levels were significantly higher in the HP infected group than in the non-infected group (P < 0.05). Height, weight, body mass index, hip circumference, albumin levels, albumin to globulin ratio, triglycerides levels, and uric acid levels were significantly higher in the non-infected group than in the infected group (P < 0.05). Multifactorial analysis revealed that HP infection was significantly associated with the risk of decreased serum albumin levels (odds ratio [OR] = 0.809, P = 3.51×10 −4 ); HP infection was significantly associated with the risk of increased serum globulin levels (model 1: OR = 1.257, P = 1.39× 10 −4 ); and HP infection was significantly associated with the risk of decreased albumin/globulin ratio (OR= 0.775, P = 2.30×10 −5 ). Conclusion HP infection was significantly associated with lower serum albumin levels, elevated globulin levels, and lower albumin/globulin ratio. Thus, it is an important factor affecting nutritional metabolism.

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“…We obtained the age-speci c gastric cancer incidence from Chinese literature about the 2012 cancer incidence analysis of Wuwei Municipality, Gansu Province, China [21]. We employed H. pylori prevalence according to an all-age population-based cross-sectional study in the Wuwei region [22]. The initial distributions of the cost-effectiveness analysis in different Markov states were determined from the Wuwei Cohort epidemiologic database (Supplementary Table S2).…”

Section: Input Parametersmentioning

confidence: 99%

Cost-effectiveness analysis of multiple gastric cancer screening strategies in Northwest China based on a population program: a Markov modeling study

Liu

Zheng

Zhou

et al. 2022

Preprint

Self Cite

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Background Gastric cancer remains a significant global health problem and poses heavy public health and economic burdens on the health system. This study aimed to compare cost-effectiveness among multiple gastric cancer screening strategies and identify the most cost-effective one in Northwest China based on a population-based cohort study using a Markov model. Methods Based on the real-world data, a Markov model was developed to evaluate the cost-effectiveness of 21 screening strategies with various screening methods, starting ages, stopping ages, and screening intervals versus no screening for a high-risk gastric cancer population in China. The primary outcomes were quality-adjusted life-years (QALY), costs, effectiveness, and the incremental cost-effectiveness ratio (ICER). One-way and probabilistic sensitivity analyses explored uncertainty. Results Our baseline model of annual endoscopic screening for individuals aged 40 to 75 years was the cost-effective strategy, with an ICER of US$ 545.79/QALY compared with no screening. In the scenario analysis, only the H. pylori screen-and-treat from 20 years strategy was non-dominated, with an ICER of US$ 157.41/QALY, and all other systems were dominated (providing less benefit but higher cost). Using the US$ 15,000 per QALY, all selected screening strategies for gastric cancer were cost-effective in the high-risk region of Northwest China. One-way and probabilistic sensitivity analyses demonstrated that the results are robust. Conclusions This modelling study provides evidence for the cost-effectiveness of an endoscopic screening program for gastric cancer in the high-risk region of China. Primary prevention appears more cost-effective than secondary prevention strategies. If primary prevention is not an option, secondary prevention strategies should be considered. All selected screening strategies seem to be cost-effective in the high-incidence area of Northwest China.

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Prevalence and risk factors of Helicobacter pylori infection in Wuwei, a high‐risk area for gastric cancer in northwest China: An all‐ages population‐based cross‐sectional study

Cited by 16 publications

References 42 publications

Family-based Helicobacter pylori infection status and transmission pattern in central China, and its clinical implications for related disease prevention

Family-based Helicobacter pylori infection status and transmission pattern in central China, and its clinical implications for related disease prevention

Helicobacter pylori Infection as a Risk Factor for Abnormal Serum Protein Levels in General Population of China

Cost-effectiveness analysis of multiple gastric cancer screening strategies in Northwest China based on a population program: a Markov modeling study

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