Prevalence and Risk Factors of Atrophic Gastritis and Intestinal Metaplasia: A Nationwide Multicenter Prospective Study in Korea

Abstract

Background/AimsAtrophic gastritis (AG) and intestinal metaplasia (IM) are premalignant gastric lesions. The aims of this study were to evaluate the prevalence of endoscopic AG and IM and to document the risk factors for these lesions.MethodsIn total, 4,023 subjects were enrolled at eight hospitals in Korea. AG and IM were diagnosed by endoscopy. Helicobacter pylori immunoglobulin G antibodies were measured.ResultsThe prevalences of endoscopic AG and IM were 40.7% and 12.5%. In a multivariate analysis, the risk factors for AG were age groups of 40 to 59 years and >60 years, male sex, positive H. pylori serology, IM, and education below the college level (odds ratio [OR], 2.55, 5.00, 1.38, 1.41, 4.29, and 1.35, respectively). The risk factors for IM were age groups of 40 to 59 years and >60 years, male sex, positive H. pylori serology, AG, having relatives with gastric cancer, education below the college level and consumption of dairy products (OR, 3.16, 3.25, 1.88, 2.17, 3.68, 1.48, 1.47, and 1.40, respectively).ConclusionsA nationwide survey regarding the prevalence of endoscopic AG and IM and their risk factors in Korea supports the hypothesis that endoscopic diagnosis of these premalignant lesions could be helpful to describe a group at high risk for gastric cancer.

The Progression of Atrophic Gastritis to Gastric Cancer: A Retrospective Study in 61,810 Cases

“…So the vigilant follow-up in the high risk groups, such as atrophic gastritis populations, is an effective strategy for improving the bad condition of gastric cancer. In Western countries, AG is generally observed in histological examination of random biopsies obtained during endoscopy; whereas in Asian countries including China, the presence and extension of AG are frequently observed by endoscopy [11]. From our conclusions, the accuracy of endoscopy diagnosis of atrophic gastritis is low, only 46.80%, and the miss diagnosis rate is high, up to 35.23%.…”

The Association between Metaplasia and Gastric Malignancy with Helicobater pylori Infection

“…Health check-up endoscopy is a well-known screening test for gastric malignancy. 9 In our study, there was a gastric malignancy of the subjects with a negative H. pylori infection. Some studies described about H. pylori-negative gastric cancers (HpNGC) cases, and the prevalence was about 0.42-5.4% of the gastric malignancy total insidence.…”

“…inflammation of gastric mucosa associated with H. pylori infection, atrophic gastritis, intestinal metaplasia, dysplasia, and intestinal type gastric malignancy. 9 The histologic developmental mechanisms remain unknown. 14 Intestinal metaplasia is defined as the replacement of gastric columnar epithelial cells into intestinal morphological cells, which is characterized by goblet cells, Paneth cells, and absorptive cells.…”

Observation Time for Complete Endoscopy in Gastric Cancer Screening

“…1 한국인에서는 위암의 위험도가 높아진다고 알려 져 있는 위축성 위염과 장상피화생의 빈도가 내시경 육안 관찰 혹은 조직검사를 통한 확인 모두에서 약 40% 정도로 높다. 2,3 따라서 한국인에서 위암의 유병률은 매우 높다. 4 …”