Prevalence and Risk Factors of Asymptomatic Peripheral Arterial Disease in Patients with COPD in Taiwan

Abstract

AimChronic obstructive pulmonary disease (COPD) is an independent risk factor for cardiovascular morbidity and mortality. The aim of this study was to determine the prevalence of asymptomatic peripheral arterial disease (PAD) and the associated risk factors for patients with COPD.MethodsThis prospective cross-sectional study enrolled 427 COPD patients (mean age: 70.0 years) without PAD symptoms consecutively. Demographic data, lung function and cardiovascular risk factors were recorded. The ankle-brachial index (ABI) was used to detect PAD (ABI<0.90).ResultsThe overall prevalence of asymptomatic PAD in the COPD patients was 8% (2.5% in the younger participants (<65 years of age, n = 118) and 10% in the elderly participants (≥65 years of age, n = 309). The COPD patients with asymptomatic PAD had a significantly higher rate of hyperlipidemia (47.1% vs. 10.4%) and hypertension (79.4% vs. 45.8%) than those without asymptomatic PAD (p<0.05). There was no significant difference in lung function (forced vital capacity and forced expiratory volume in one second) between the two groups. In multivariate logistic regression, hyperlipidemia was the strongest independent factor for PAD (odds ratio (OR): 6.89, p<0.005), followed by old age (OR: 4.80), hypertension (OR: 3.39) and smoking burden (pack-years, OR: 1.02).ConclusionsThe prevalence of asymptomatic PAD among COPD patients in Taiwan is lower than in Western countries. Hyperlipidemia, old age, hypertension, and smoking burden were the associated cardiovascular risk factors. However, there was no association between lung function and PAD in the COPD patients.

Peripheral Artery Disease and Its Clinical Relevance in Patients with Chronic Obstructive Pulmonary Disease in the COPD and Systemic Consequences–Comorbidities Network Study

“…In a Taiwanese cohort of 427 patients with COPD, 8% of the patients were identified with asymptomatic PAD (34). Although the severity stages of COPD in this Taiwanese cohort were comparable to those in our cohort, the generalizability of these data is difficult, as almost exclusively male patients (98%) were enrolled in this single-center study.…”

Combined Reduced Forced Expiratory Volume in 1 Second (FEV1) and Peripheral Artery Disease in Sedentary Elders With Functional Limitations

“…Lung function was additionally based on a novel, more age-appropriate method for reporting the FEV1, 1,18,19,23 not previously evaluated regarding the combined occurrence of a reduced FEV1 and PAD. 8-11 …”

“…8-11 As a result, the combined prevalence of a reduced FEV1 and PAD, including its clinical relevance, remains to be established in sedentary elders with functional limitations. 15 Accordingly, and because they are potentially modifiable, we have evaluated the combined occurrence of a reduced FEV1 and PAD, including cross-sectional associations with exertional symptoms, physical inactivity, and impaired mobility in a large sample of sedentary community-dwelling elders with functional limitations (SPPB<10) — i.e., Lifestyle Interventions and Independence for Elders (LIFE) Study.…”

Associação do fluxo sanguíneo periférico e capacidade funcional em amputados de membro inferior

“…1,12,13 A DAP, resultante de um processo aterosclerótico, que afeta as artérias coronárias e promove a oclusão de artérias dos membros inferiores, é amplamente variável ao redor do mundo, e no Brasil ainda há poucos registros na literatura atual, sendo que sua identificação é de fundamental importância já que esta aumenta o risco de evento cardiovascular e possível amputação contralateral. 10,12 Mesmo conhecendo pouco sobre a sua prevalência em sujeitos amputados, em nosso estudo, encontramos uma pequena frequência de DAP, porém foi possível identificar que as alterações no fluxo sanguíneo interferiram 84% na capacidade funcional dos amputados avaliados.…”