Prevalence and risk factors of kidney stone disease in population aged 40–70 years old in Kharameh cohort study: a cross-sectional population-based study in southern Iran

Moftakhar, Leila; Jafari, Fatemeh; Johari‬, Masoumeh Ghoddusi; Rezaeianzadeh, Ramin; Hosseini, Seyed Vahid; Rezaianzadeh, Abbas

doi:10.1186/s12894-022-01161-x

Cited by 24 publications

(14 citation statements)

References 62 publications

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“…One interesting finding highlighted by this study was that male patients had a significantly higher positive rate. Possible explanations are that males more frequently have an established urologic history 19,20 ; thus, existing workup records may incidentally uncover upper tract pathologies. The incidence of renal cell carcinomas in males is up to twice of that of females, 21 leading to an anticipatory diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Urine cytology in the detection of renal cell carcinomas – a territory‐wide multi‐institutional retrospective review of more than 2 decades

Li,

Ng,

Tang

et al. 2024

Cancer Cytopathology

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IntroductionCompared with urothelial lesions of the upper urinary tract, the diagnostic performance of urine cytology in detection of renal cell carcinomas is underreported. This study aims to establish the role of urine cytology in the assessment of renal carcinomas by a multi‐institute review of urine cytology from nephrectomy confirmed renal cell carcinomas, referenced against renal urothelial and squamous cell carcinomas.MethodsRecords of nephrectomy performed from the 1990s to 2020s at three hospitals were retrieved and matched to urine cytology specimens collected within 1 year prior. Patient demographics, specimen descriptors, and histology and staging parameters were reviewed and compared against cytologic diagnoses.ResultsThere were 1147 cases of urine cytology matched with renal cell carcinomas, with 666 renal urothelial/squamous carcinomas for comparison. The detection rate for urothelial/squamous (atypia or above [C3+]: 63.1%; suspicious or above [C4+]: 24.0%) were higher than renal cell carcinoma (C3+: 13.1%; C4+: 1.5%) (p < 0.001). The positive rate for upper tract urine exceeded other collection methods at 45.0% (C3+) and 10.0% (C4+) (p < .01). Other factors associated with increased positive rates were male sex, collecting duct carcinoma histology, nuclear grade, and renal/sinus involvement (p < .05). Multivariate analysis revealed additional positive correlations with presence of sarcomatoid tumor cells, lymphovascular invasion, and perinephric fat involvement (p < .05). Larger lesion size and higher urine volume did not improve detection rates (p < .05).ConclusionsThe detection rate of renal cell carcinomas is suboptimal compared with urothelial carcinomas, although urine samples collected from cystoscopy or percutaneous nephrostomy significantly outperformed voided urine specimens.

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Section: Discussionmentioning

confidence: 99%

Urine cytology in the detection of renal cell carcinomas – a territory‐wide multi‐institutional retrospective review of more than 2 decades

Li,

Ng,

Tang

et al. 2024

Cancer Cytopathology

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“…Physical activity levels were also assessed using standard questionnaires that measure daily activity. The calculation of the SES of people and the level of physical activity is also described in other studies of the Kharamah cohort 9,10 …”

Section: Methodsmentioning

confidence: 99%

“…The calculation of the SES of people and the level of physical activity is also described in other studies of the Kharamah cohort. 9,10 Behavioral habits also included levels of physical activity, smoking, alcohol consumption, and anthropometric characteristics, including body mass index (BMI), waist circumference, and hip circumference. A history of diabetes, fatty liver, and chronic kidney disease was also evaluated.…”

Section: Data Collectionmentioning

confidence: 99%

The effect of prehypertension and hypertension on the incidence of cardiovascular disease: A population‐based cohort study in Kharameh, a city in the South of Iran

Moftakhar

Rezaianzadeh

Seif

et al. 2023

Health Science Reports

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Background and Aim: Prehypertension and hypertension are important risk factors for cardiovascular diseases. This study was carried out to evaluate the effect of prehypertension and hypertension on the development of cardiovascular diseases.Methods: This prospective cohort study was performed on 9442 people aged 40−70 in Kharameh, southern Iran. Individuals were divided into three groups: normal blood pressure (N = 5009), prehypertension (N = 2166), and hypertension (N = 2267). In this study, demographic data, disease histories, behavioral habits, and biological parameters were studied. At first, the incidence density was calculated. Then Firth's Cox regression models were used to investigate the association between prehypertension and hypertension with the incidence of cardiovascular diseases. Results:The incidence density in the three groups of individuals with normal blood pressure, prehypertension, and hypertension was 1.33, 2.02, and 3.29 cases per 100,000 person-days, respectively. The results of multiple Firth's Cox regression by controlling all factors showed that the risk of occurrence of cardiovascular disease in people with prehypertension was 1.33 times (hazard ratio [HR] = 1.32, 95% confidence interval [CI]: 1.01−1.73, p = 0.03) and those with hypertension were 1.85 times higher (HR = 1.77, 95% CI: 1.38−2.29, p < 0.0001) than the individuals with normal blood. Conclusion:Prehypertension and hypertension have played an independent role in the risk for developing cardiovascular diseases. Therefore, early detection of individuals with these factors and control of other risk factors in them can contribute to reducing the occurrence of cardiovascular diseases.

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“…The inclusion criteria for the Kharameh cohort study were age 40–70 years and at least 9 months of residence in Kharameh to allow time to adapt to the environment and culture [ 13 ]. Exclusion criterion was the individuals with mental retardation or mental disorders who could not participate in the study.…”

Section: Methodsmentioning

confidence: 99%

Incidence and risk factors of cardiovascular disease among population aged 40–70 years: a population-based cohort study in the South of Iran

et al. 2023

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Background Cardiovascular diseases are the main cause of mortality in the world. This study aimed to estimate the incidence and identify the risk factors of these diseases. Methods This prospective cohort study was performed on 9442 individuals aged 40–70 years in Kharameh, a city in the South of Iran, in 2015–2022. The subjects were followed up for 4 years. The demographic information, behavioral habits, biological parameters, and history of some diseases were examined. The density incidence of cardiovascular disease was calculated. The log-rank test was calculated to assess the cardiovascular incidence difference between men and women. Simple and multiple Cox regression with Firth's bias reduction method were used to identify the predictors of cardiovascular disease. Results The mean ± SD age of the participants was 51.4 ± 8.04 years, and the density incidence was estimated at 1.9 cases per 100,000 person-day. The log-rank test showed that men had a higher risk of cardiovascular disease than women. The Fisher's exact test showed a statistically significant difference between the incidence of cardiovascular diseases in different age groups, education levels, diabetes, and hypertension in men and women. The results of multiple Cox regression revealed that with increasing age, the risk of developing CVDs increased. In addition, the risk of cardiovascular disease is higher in people with kidney disease (HRadj = 3.4, 95% CI 1.3 to 8.7), men (HRadj = 2.3, 95% CI 1.7 to 3.2), individuals with hypertension (HRadj = 1.6, 95% CI 1.3 to 2.1), diabetics (HRadj = 2.3, 95%c CI 1.8 to 2.9), and alcohol consumption (HRadj = 1.5, 95% CI 1.09 to 2.2). Conclusions In the present study, diabetes, hypertension, age, male gender, and alcohol consumption were identified as the risk factors for cardiovascular diseases; three variables of diabetes, hypertension and alcohol consumption were among the modifiable risk factors, so if they were removed, the incidence of cardiovascular disease could greatly reduce. Therefore, it is necessary to develop strategies for appropriate interventions to remove these risk factors.

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Prevalence and risk factors of kidney stone disease in population aged 40–70 years old in Kharameh cohort study: a cross-sectional population-based study in southern Iran

Cited by 24 publications

References 62 publications

Urine cytology in the detection of renal cell carcinomas – a territory‐wide multi‐institutional retrospective review of more than 2 decades

Urine cytology in the detection of renal cell carcinomas – a territory‐wide multi‐institutional retrospective review of more than 2 decades

The effect of prehypertension and hypertension on the incidence of cardiovascular disease: A population‐based cohort study in Kharameh, a city in the South of Iran

Incidence and risk factors of cardiovascular disease among population aged 40–70 years: a population-based cohort study in the South of Iran

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