Prevalence and risk factors of preoperative venous thromboembolism in patients with malignant musculoskeletal tumors: an analysis based on D-dimer screening and imaging

Hayashida, Kenta; Kawabata, Yusuke; Saito, Keiju; Fujita, Shintaro; Choe, Han-Cheol; Kato, Ikuma; Takeyama, Masanobu; Inaba, Yutaka

doi:10.1186/s12959-022-00382-2

Cited by 6 publications

(5 citation statements)

References 37 publications

(36 reference statements)

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“…There have been cases of the VTE risks being elevated to as much as 28-fold in certain types of malignancies. 10 , 11 Consistent with other previous studies, certain cancers were also discovered to be more predisposed to prothrombotic tendencies; and associated with disease staging, bed rest, as well as the therapeutic interventions employed. Evidence of TE has also been described in 5–10% of patients with breast cancer despite undergoing adjuvant chemotherapy with about 15% in those having metastatic disease.…”

Section: Introductionsupporting

confidence: 85%

Thrombotic Pathogenesis and Laboratory Diagnosis in Cancer Patients, An Update

Akinbo

Ajayi

2023

IJGM

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Cancer-associated thrombosis (CAT) is a leading cause of mortality in cancer patients and its incidence varies in different parts of the world. Venous thromboembolism (VTE) is a prominent manifestation of CAT, and significantly impacts morbidity and survival compared to arterial thrombosis in cancer patients. Several risk factors for developing VTE such as chemotherapy and immobilization have also been found co-existing with cancer patients and contributing to the increased risk of VTE in cancer patients than in non-cancer patients. This review highlights recent mechanisms in the pathogenesis of hypercoagulable syndromes associated with cancer, multiple mechanisms implicated in promoting cancer-associated thrombosis and their diagnostic approaches. Cancer cells interact with every part of the hemostatic system; generating their own procoagulant factors, through stimulation of the prothrombotic properties of other blood cell components or the initiation of clotting by cancer therapies which can all directly activate the coagulation cascade and contribute to the VTE experienced in CAT. It is our hope that the multiple interconnections between the hemostatic system and cancer biology and the improved biomarkers reported in this study can be relevant in establishing a predictive model for VTE, optimize early detection of asymptomatic microthrombosis for more personalized prophylactic strategies and incorporate effective therapeutic options and patient management to reduce mortality and morbidity, and improve the quality of life of affected cancer patients.

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Section: Introductionsupporting

confidence: 85%

Thrombotic Pathogenesis and Laboratory Diagnosis in Cancer Patients, An Update

Akinbo

Ajayi

2023

IJGM

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“…In the present study VTE showed a statistically significant association with high D dimer (ng/ml), sPselectin (ng/ml), Khorana score, and Vienna CATS score. This is in similarity to Li et al (22) who reported that VTE showed a statistically significant association with high D dimer (P<0.05), but contrary to Hayashida et al (23) who found that D-dimer levels were not associated with VTE in the multivariate analysis, likely because they are affected by many risk factors, such as cancer and aging.…”

supporting

confidence: 86%

Validity of Modified Vienna-CATS Score for Prediction of Venous Thromboembolism in Egyptian Cancer Cases

El-sayed

Ebrahim²,

Ghoneim³

et al. 2022

The Egyptian Journal of Hospital Medicine

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Background: Modern oncology has a compelling problem in predicting the hazards of venous thromboembolism (VTE) linked with chemotherapy. Although thromboprophylaxis is not now advised for primary prevention, it is typically advised that cases' risks of VTE be evaluated before treatment. Great interest was given to establishing effective predictive methods for VTE in cancer cases. The aim of this study:The study aimed to detect whether Egyptian cancer cases' VTE risk could be predicted using the modified Vienna Cancer and Thrombosis Study (CATS) score. Methods: 214 newly diagnosed cancer cases participated in a prospective cohort study completed before receiving chemotherapy. Cases who received chemotherapy were monitored for VTE episodes for six months. The Khorana score was determined. D dimer and soluble P-selectin (sP-selectin) levels were assessed, followed by a modified Vienna CATS score. For each example, the Vienna CATS score was determined. Results: Only 24 (11.2%) of the 214 cases who had follow-up experienced VTE episodes, and 5 of these (2.3%) were lost. Conclusion:When compared to the Khorana score, the modified Vienna CATS score was more sensitive in identifying cancer cases at risk for VTE. Implementation of modified Vienna CATS in the clinical workup of cancer cases could help physicians to tailor antithrombotic therapy and lead to the perfect use of thromboprophylaxis.

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“…Supported by several other reports, cancer-associated VTE frequently occurred in the older age group ( 18 , 19 ). Interestingly, Hayashida et al ( 20 ) indicated that patients over 60 years of age had half the risk of experiencing VTE as patients <60 years of age (P<0.05). With the development of enhanced recovery after thoracic surgery (ERAS) ( 21 ), we should focus more on older patients and increase interventions to reduce the occurrence of VTE.…”

Section: Discussionmentioning

confidence: 99%

Risk assessment for postoperative venous thromboembolism using the modified Caprini risk assessment model in lung cancer

Ding¹,

Yao²,

Tan³

et al. 2023

J Thorac Dis

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Background Postoperative venous thromboembolism (VTE) is a well-documented cause of morbidity and mortality in lung cancer patients. However, risk identification remains limited. In this study, we sought to analyze the risk factors for VTE and verify the predictive value of the modified Caprini risk assessment model (RAM). Methods This prospective single-center study included patients with resectable lung cancer who underwent resection between October 2019 and March 2021. The incidence of VTE was estimated. Logistic regression was used to analyze the risk factors for VTE. Receiver operating characteristic (ROC) curve analysis was performed to test the ability of the modified Caprini RAM to predict VTE. Results The VTE incidence was 10.5%. Several variables, including age, D-dimer, hemoglobin (Hb), bleeding, and patient confinement to bed were significantly associated with VTE after surgery. The difference between the VTE and non-VTE groups in the high-risk levels was statistically significant (P<0.001), while the low and moderate risk levels showed no significant difference. The combined use of the modified Caprini score and the Hb and D-dimer levels showed an area under the curve (AUC) was 0.822 [95% confidence interval (CI): 0.760–0.855. P<0.001]. Conclusions The risk-stratification approach of the modified Caprini RAM is not particularly valid after lung resection in our population. The use of the modified Caprini RAM combined with Hb and D-dimer levels shows a good diagnostic performance for VTE prediction in patients with lung cancer undergoing resection.

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Prevalence and risk factors of preoperative venous thromboembolism in patients with malignant musculoskeletal tumors: an analysis based on D-dimer screening and imaging

Cited by 6 publications

References 37 publications

Thrombotic Pathogenesis and Laboratory Diagnosis in Cancer Patients, An Update

Thrombotic Pathogenesis and Laboratory Diagnosis in Cancer Patients, An Update

Validity of Modified Vienna-CATS Score for Prediction of Venous Thromboembolism in Egyptian Cancer Cases

Risk assessment for postoperative venous thromboembolism using the modified Caprini risk assessment model in lung cancer

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