Prevalence and risk factors of discomfort in infants with severe bronchiolitis

Berlendis, Justine Leboucher

doi:10.1111/apa.16305

Cited by 3 publications

(2 citation statements)

References 24 publications

(42 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Notably, according to the baseline data (lower S/F ratio and higher heart rate and PRISM III score at NIV initiation), the sedation group seemed to have a signi cantly more severe condition than did the nonsedation group. This nding may agree with the hypothesis put forward by Leboucher et al, who stated that patients in the most severe condition are the most uncomfortable or that at least they are perceived as such (9). However, multivariate analysis did not include the use of sedatives in the predictive model for the need for intubation, demonstrating that only the PRISM III score at NIV initiation and respiratory rate at 3 hours were included in the nal model.…”

Section: Discussionsupporting

confidence: 87%

See 1 more Smart Citation

Implications of Sedation During the Use of Non-invasive Ventilation in Children with Acute Respiratory Failure (SEDANIV Study)

Barrezueta,

Mayordomo-Colunga,

Miñambres-Rodríguez

et al. 2024

Preprint

View full text Add to dashboard Cite

Background: The objective of this study was to analyze the effects of sedation administration on clinical parameters, comfort status, intubation requirements, and the pediatric intensive care unit (PICU) length of stay (LOS) in children with acute respiratory failure (ARF) receiving noninvasive ventilation (NIV). Methods: Thirteen PICUs in Spain participated in a prospective, multicenter, observational trial from January to December 2021. Children with ARF under the age of five who were receiving NIV were included. Clinical information and comfort levelswere documented at the time of NIV initiation, as well as at 3, 6, 12, 24, and 48 hours. The COMFORT-behavior (COMFORT-B) scale was used to assess the patients’ level of comfort. NIV failure was considered to be a requirement forendotracheal intubation. Results: A total of 457 patients were included, with a median age of 3.3 months (IQR 1.3-16.1). Two hundred and thirteen children (46.6%) received sedation (sedation group); these patients had a higher heart rate, higher COMFORT-B score, and lower S/F ratio than did those who did not receive sedation (non-sedationgroup). A significantly greater improvement in the COMFORT-B score at 3, 6, 12, and 24 hours, heart rate at 6 and 12 hours, and S/F ratio at 6 hours was observed in the sedation group. Overall, the NIV success rate was 95.6% -intubation was required in 6.1% of the sedation group and in 2.9% of the other group (p =0.092). Multivariate analysis revealed that the PRISM III score at NIV initiation (OR 1.408; 95% CI 1.230–1.611) and respiratory rate at 3 hours (OR 1.043; 95% CI 1.009–1.079) were found to be independent predictors of NIV failure. The PICU LOS was correlated with weight, PRISM III score, respiratory rate at 12 hours, SpO2 at 3 hours, FiO2 at 12 hours, NIV failure and NIV duration. Sedation use was not found to be independently related to NIV failure or to the PICU LOS. Conclusions: Sedation use may be useful in children with ARF treated with NIV, as it seems to improve clinical parameters and comfort status but may not increase the NIV failure rate or PICU LOS, even though sedated children were more severe at technique initiation in the present sample.

show abstract

Section: Discussionsupporting

confidence: 87%

“…Moreover, its effectiveness in children has been widely demonstrated (1)(2)(3)(4)(5)(6)(7)(8). During the use of NIV, patient adaptation to this kind of respiratory support should be optimal to achieve maximum effectiveness, thus constituting a critical determinant of NIV success (9,10,11).…”

Section: Introductionmentioning

confidence: 99%

Implications of Sedation During the Use of Non-invasive Ventilation in Children with Acute Respiratory Failure (SEDANIV Study)

Barrezueta,

Mayordomo-Colunga,

Miñambres-Rodríguez

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

Association of enteral feeds in critically ill bronchiolitis patients supported by high-flow nasal cannula with adverse events and outcomes

et al. 2023

View full text Add to dashboard Cite

Implications of sedation during the use of noninvasive ventilation in children with acute respiratory failure (SEDANIV Study)

Bermúdez-Barrezueta,

Mayordomo-Colunga,

Miñambres-Rodríguez

et al. 2024

Crit Care

View full text Add to dashboard Cite

Background The objective of this study was to analyze the effects of sedation administration on clinical parameters, comfort status, intubation requirements, and the pediatric intensive care unit (PICU) length of stay (LOS) in children with acute respiratory failure (ARF) receiving noninvasive ventilation (NIV). Methods Thirteen PICUs in Spain participated in a prospective, multicenter, observational trial from January to December 2021. Children with ARF under the age of five who were receiving NIV were included. Clinical information and comfort levels were documented at the time of NIV initiation, as well as at 3, 6, 12, 24, and 48 h. The COMFORT-behavior (COMFORT-B) scale was used to assess the patients’ level of comfort. NIV failure was considered to be a requirement for endotracheal intubation. Results A total of 457 patients were included, with a median age of 3.3 months (IQR 1.3–16.1). Two hundred and thirteen children (46.6%) received sedation (sedation group); these patients had a higher heart rate, higher COMFORT-B score, and lower SpO2/FiO2 ratio than did those who did not receive sedation (non-sedation group). A significantly greater improvement in the COMFORT-B score at 3, 6, 12, and 24 h, heart rate at 6 and 12 h, and SpO2/FiO2 ratio at 6 h was observed in the sedation group. Overall, the NIV success rate was 95.6%-intubation was required in 6.1% of the sedation group and in 2.9% of the other group (p = 0.092). Multivariate analysis revealed that the PRISM III score at NIV initiation (OR 1.408; 95% CI 1.230–1.611) and respiratory rate at 3 h (OR 1.043; 95% CI 1.009–1.079) were found to be independent predictors of NIV failure. The PICU LOS was correlated with weight, PRISM III score, respiratory rate at 12 h, SpO2 at 3 h, FiO2 at 12 h, NIV failure and NIV duration. Sedation use was not found to be independently related to NIV failure or to the PICU LOS. Conclusions Sedation use may be useful in children with ARF treated with NIV, as it seems to improve clinical parameters and comfort status but may not increase the NIV failure rate or PICU LOS, even though sedated children were more severe at technique initiation in the present sample.

show abstract

Prevalence and risk factors of discomfort in infants with severe bronchiolitis

Cited by 3 publications

References 24 publications

Implications of Sedation During the Use of Non-invasive Ventilation in Children with Acute Respiratory Failure (SEDANIV Study)

Implications of Sedation During the Use of Non-invasive Ventilation in Children with Acute Respiratory Failure (SEDANIV Study)

Association of enteral feeds in critically ill bronchiolitis patients supported by high-flow nasal cannula with adverse events and outcomes

Implications of sedation during the use of noninvasive ventilation in children with acute respiratory failure (SEDANIV Study)

Contact Info

Product

Resources

About