Prevalence and Risk Factors of H. pylori from Dyspeptic Patients in Northwest Ethiopia: A Hospital Based Cross-sectional Study

Abebaw, Wubejig; Kibret, Mulugeta; Abera, Bayeh

doi:10.7314/apjcp.2014.15.11.4459

Cited by 52 publications

(58 citation statements)

References 36 publications

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“…Evidently, study on H. pylori positive asymptomatic and symptomatic subjects with acid peptic disease showed that the risk of virulent infection was escalated by smoking in both groups of individual 33 . Statistically significant association was observed (Pvalue=0.030) in the prevalence of H. pylori infection and type of occupations in this study which is in line with other studies 34,35 . Presumably, the variation in prevalence could be due to the difference in the lifestyles, exposure to potential environmental sources and habits.…”

Section: Discussionsupporting

confidence: 93%

“…Among the socio-demographic characteristics of the participants, statistically significant difference was not obtained for educational attainment which is in agreement to studies 38,39 and inconsistent to other studies 34,40 . The absences of association in this study might be due to less number of non-educated subjects that cause difficulty to compute the association.…”

Section: Discussioncontrasting

confidence: 46%

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Prevalence of Helicobacter Pylori Among Asymptomatic Populations in Sana'a, Yemen

Alyahawi

Al-kaf

Alzaghrori

2018

UJPR

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Helicobacter pylori consider the most important cause of chronic gastritis and also the most important etiological factor responsible for the duodenal and gastric ulcer and have an important role in the pathogenesis of gastric cancer. The aim of the present study to know the prevalence of H. pylori among the khat chewing adults in compared to non-khat chewing among asymptomatic populations. A total of 82 healthy subjects were screened to find out the prevalence of Helicobacter pylori using stool antigen card test during the period started in 16 April 2018 and ending in 8 May 2018 in Sana'a, Yemen. Predesigned questionnaire was used to collect information such as age, sex, education status, khat chewing, smoking, tobacco chewing, occupation, and tests results all above data were recorded for each subject. Patients who had taken proton pump inhibitors or antibiotic for a month prior to study were excluded. Out of these 82 asymptomatic individuals, 36 were found positive for Helicobacter pylori by the test, giving a prevalence of 43.9 %. A prevalence of 26.9 % (62.9 % of khat chewing) was khat chewing individuals and it had statistically significant difference. A prevalence of 14.6 % was seen among cigarette smoking participants. The present study revealed substantial prevalence of Helicobacter pylori in khat chewing healthy subjects. A higher prevalence of Helicobacter pylori seen in these subjects may be contributed to khat chewing. Identification of khat chewing populations, who do not show symptoms of Helicobacter pylori infection, is essential for controlling the infection and it still remains a challenge for the clinicians.

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Section: Discussionsupporting

confidence: 93%

Section: Discussioncontrasting

confidence: 46%

Prevalence of Helicobacter Pylori Among Asymptomatic Populations in Sana'a, Yemen

Alyahawi

Al-kaf

Alzaghrori

2018

UJPR

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“…Regular washing hand after defecation and no taking food by hand appeared as protective factors for H. pylori infection in ethnic people in Vietnam [12,29]. Abebaw et al also reported higher rate of H. pylori infection in people who used unprotected surface water and irregular washing hand before meal [30]. Children who did not regularly receive chewed food were less likely to be H. pylori seropositive (adjusted OR: 0.58, 95% CI 0.31-0.80, p=0.04).…”

Section: Discussionmentioning

confidence: 94%

Prevalence and Risk Factors of Helicobacter pylori Infection in Muong Children in Vietnam

Nguyen¹

2017

Ann Clin Lab Res

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Aim: H. pylori infection is predominantly acquired in early childhood. The aim of the present study was to determine the prevalence of H. pylori infection and to identify factors associated with the infection in Muong children living in Vietnam. Materials and methods:In a cross-sectional study 918 asymptomatic individuals of all generations living together in the same home were selected from 219 households, based on cluster sampling of residential location in Hoabinh Province, Vietnam. H. pylori infection status was determined by serology test on samples obtained at each visit. A questionnaire was filled out at the start of the study. H. pylori serology data were analyzed using χ 2 test and logistic regression models. Results Conclusion:The first community-based study in Muong population showed familial clustering in multi-generation population and supported the hypothesis of person-toperson transmission in H. pylori infection

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“…Currently, several epidemiological and experimental data support a pathological role between H. pylori and the development of gastric cancer (Parsonnet et al, 1991, Uemura et al, 2001, Demirel et al, 2013, Karami et al, 2013, Basiri et al, 2014. At the present time, H. pylori infects more than 50% of the global population mainly in the developing countries (Abebaw et al, 2014). It was estimated that H. pylori infection accounts for approximately 650,000 new cases of non-cardiac gastric cancer annually (de Martel et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

“…The causal relationship between of H. pylori and the development of gastric cancer has been documented in both epidemiological and basic research studies (Parsonnet et al, 1991, Uemura et al, 2001, Demirel et al, 2013, Karami et al, 2013, Basiri et al, 2014 Abebaw et al, 2014). Moreover, a recent meta-analysis has shown that H. pylori eradication potentially reduces the incidence of gastric cancer, especially in the areas where the prevalence of gastric cancer is high (Fock, 2014, Ford et al, 2014.…”

Section: Introductionmentioning

confidence: 99%

Improved Eradication Rate of Standard Triple Therapy by Adding Bismuth and Probiotic Supplement for Helicobacter pylori Treatment in Thailand

Srinarong¹,

Siramolpiwat²,

Wongcha-um³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: Helicobacter pylori (H. pylori) remains an important cause of gastric cancer and peptic ulcer disease worldwide. Treatment of H. pylori infection is one of the effective ways to prevent gastric cancer. However, standard triple therapy for H. pylori eradication is no longer effective in many countries, including Thailand. This study was designed to evaluate the efficacy of adding bismuth and probiotic to standard triple therapy for H. pylori eradication. Materials and Methods: In this prospective single center study, H. pylori infected gastritis patients were randomized to receive 7-or 14-day standard triple therapy plus bismuth with probiotic or placebo. Treatment regimen consisted of 30 mg lansoprazole twice daily, 1 g amoxicillin twice daily, 1 g clarithromycin MR once daily and 1,048mg bismuth subsalicylate twice daily. Probiotic bacteria composed of Bifidobacterium lactis, Lactobacillus acidophilus and Lactobacillus paracasei. Placebo was conventional drinking yogurt without probiotic. CYP2C19 genotyping and antibiotic susceptibility tests were also done. H pylori eradication was defined as a negative 13 C-urea breath test at least 2 weeks after completion of treatment. Results: One hundred subjects were enrolled (25 each to 7-and 14-day regimens with probiotic or placebo). Antibiotic susceptibility tests showed 36.7% metronidazole and 1.1% clarithromycin resistance. CYP2C19 genotyping revealed 40.8%, 49% and 10.2% were rapid, intermediate and poor metabolizers, respectively. The eradication rates of 7-or 14 regimens with probiotics were 100%. Regarding adverse events, the incidence of bitter taste was significantly lower in the 7-day regimen with the probiotic group compared with 7-day regimen with placebo (40% vs. 64%; p=0.04). Conclusions: The 7-day standard triple therapy plus bismuth and probiotic can provide an excellent cure rate of H. pylori (100%) in areas with low clarithromycin resistance such as Thailand, regardless of CYP2C19 genotype. Adding a probiotic also reduced treatment-related adverse events.

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Prevalence and Risk Factors of H. pylori from Dyspeptic Patients in Northwest Ethiopia: A Hospital Based Cross-sectional Study

Cited by 52 publications

References 36 publications

Prevalence of Helicobacter Pylori Among Asymptomatic Populations in Sana'a, Yemen

Prevalence of Helicobacter Pylori Among Asymptomatic Populations in Sana'a, Yemen

Prevalence and Risk Factors of Helicobacter pylori Infection in Muong Children in Vietnam

Improved Eradication Rate of Standard Triple Therapy by Adding Bismuth and Probiotic Supplement for Helicobacter pylori Treatment in Thailand

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