Prevalence and risk factors of intrahepatic cholestasis of pregnancy in a Chinese population

Abstract

Studies on the risk factors for intrahepatic cholestasis of pregnancy (ICP) in a population-based cohort are lacking. We assess the prevalence and risk factors of ICP in a Chinese population. In this study, a cohort study was conducted that included 12,200 eligible pregnant women. The overall incidence of ICP in this cohort was 6.06%. With increasing maternal age, the incidence of ICP decreased in women younger than 30 years of age but increased in those older than 30. With increasing pre-pregnancy BMI, the incidence of ICP decreased if the pre-pregnancy BMI was less than 23 kg/m2 but increased if it was 23 kg/m2 or higher. Further analysis showed that the risk of ICP increased when maternal age was < 25 years (Adjusted RR 2.01; 95% CI 1.64–2.47) or ≥ 35 years (Adjusted RR 1.34; 95% CI 1.02–1.76). Furthermore, an increased risk of ICP was associated with pre-pregnancy underweight (adjusted RR 1.27; 95% CI 1.04–1.56), inadequate gestational weight gain (GWG) (adjusted RR 1.58; 95% CI 1.28–1.96), lower maternal education (adjusted RR 2.96; 95% CI 2.35–3.74), multiparity (adjusted RR 1.54; 95% CI 1.23–1.93), and twin/multiple pregnancies (adjusted RR 2.12; 95% CI 1.25–3.58). Maternal age (< 25 or ≥ 35 years), underweight, inadequate GWG, lower maternal education, multiparity, and twin/multiple pregnancies were identified as risk factors of ICP.

Intrahepatic Cholestasis of Pregnancy and Associated Adverse Maternal and Fetal Outcomes: A Retrospective Case-Control Study

“…The prevalence of ICP in this study was 3.15%, which was lower than that of other domestic studies [ 25 ]. A possible reason for this may be due to our comprehensive evidence-based management of patients with ICP and their good compliance.…”

Intrahepatic Cholestasis of Pregnancy: Role of Baby’s Sex on Itch Severity and Bile Acid Levels

“…Some causes of intrahepatic cholestasis include progressive familial intrahepatic cholestasis, primary biliary cholangitis, hepatitis, metastatic disease, certain medications, and intrahepatic cholestasis of pregnancy (ICP) [ 1 ]. ICP is the most common gestational disorder of the liver, with an occurrence that varies by ethnicity and geographic region (0.1-15.6%) [ 2 ]. Others include acute fatty liver disease of pregnancy, hemolysis with elevated liver enzymes and low platelets, and liver dysfunction from preeclampsia [ 3 ].…”

Risk Assessment in Pregnancy among Women Aged Over Forty

“…Results showed that the incidence of ICP increased with advancing maternal age if women were 30 years of age or older. The incidence of ICP decreased with increasing maternal age in women younger than 30 ( 28 ). In this study, the rate of ICP did not differ between the two groups.…”