Prevalence and risk factors of hyperuricemia and gout: a cross-sectional survey from 31 provinces in mainland China

Abstract

Background and Objetives Hyperuricemia (HUA) and gout seriously influence patients’ quality of life. The current study was performed to investigate the prevalence of HUA and gout and the related risk factors in Chinese adults. Methods Data were collected from the National Survey of Thyroid Disorders and Diabetes (the Thyroid Disease, Iodine Status, and Diabetes National Epidemiological survey [TIDE]), a cross-sectional investigation conducted during 2015–2017. Using a random, multistage, and stratified sampling strategy, a representative sample (78,130 participants aged 18 years and above) was selected from the general population in 31 provinces of mainland China. The weighted prevalence rates of HUA and gout were calculated, and the related risk factors were analyzed. Results The weighted prevalence rates of HUA and gout in Chinese adults were 17.7% and 3.2%, respectively. The prevalence of HUA in males linearly decreased with age, while the prevalence in females showed the opposite trend (both P for trend < 0.01). The prevalence rate of gout exhibited a rising tendency with age in both genders (both P for trend < 0.05). The HUA and gout prevalence rates in males were the highest in Han and Tibetan nationalities, respectively. Logistic regression analysis showed that the morbidities of HUA and gout were differentially associated with age, residence location, nationality, smoking, and other complicating metabolic diseases in the two genders. Conclusions There are relatively high prevalence rates of gout and HUA in China, which is currently a developing country. Reducing their burden has become an urgent issue for Chinese people.

Comparison of clinical and economic evaluation between selected generic and original febuxostat tablets in Chinese gout patients with hyperuricemia: A real-world multicenter retrospective study

“…[7] Partly due to the unhealthy lifestyle and the aggravation of population aging, the prevalence and incidence of gout and hyperuricemia has been constantly increasing in China, with the younger generation being affected more. [8,9] According to a recent survey from 31 provinces in mainland China, the weighted prevalence rates of hyperuricemia and gout in Chinese adults were 17.7% and 3.2%, respectively. [9] The findings suggest hyperuricemia and gout have become major public health concerns in China, and urgent measures are needed to reduce the large burden of these conditions.…”

“…[8,9] According to a recent survey from 31 provinces in mainland China, the weighted prevalence rates of hyperuricemia and gout in Chinese adults were 17.7% and 3.2%, respectively. [9] The findings suggest hyperuricemia and gout have become major public health concerns in China, and urgent measures are needed to reduce the large burden of these conditions.…”

Associations of Bisphenols Exposure and Hyperuricemia Based on Human Investigation and Animal Experiments

“…3 However, the prevalence of hyperuricemia and gout in China has increased dramatically in recent years. 4 UA is a product of purine metabolism. Serum UA levels are determined by the balance between UA production and excretion.…”

Cardiovascular safety of febuxostat versus allopurinol among the Asian patients with or without gout: A systematic review and meta‐analysis

“…Gout, a prevalent rheumatic metabolic disease, exhibits varying prevalence rates across different regions, countries, and races 1–3 . In the United Kingdom, the estimated prevalence of gout is 0.03%, whereas in Taiwan Province it is 10.42% 4 .…”