Prevalence and Risk Factors of Dry Eye Disease in Japan: Koumi Study

Uchino, Makoto; Nishiwaki, Yuji; Michikawa, Takehiro; Shirakawa, Kazuhiro; Kuwahara, Erika; Yamada, Masaya; Doğru, Murat; Schaumberg, Debra A.; Kawakita, Tetsuya; Takebayashi, Toru; Tsubota, Kazuo

doi:10.1016/j.ophtha.2011.05.029

Cited by 248 publications

(206 citation statements)

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“…Recently, the amount of work performed using VDTs has greatly increased in Japan ); DED symptoms reported by VDT users include eyestrain, reduced visual acuity, ocular pain, and dry eyes (Thomson 1998). University staff are involved in many VDT operations, therefore, prevalence of DED might be higher than that in the general population (Uchino et al 2011). Second, we surveyed medical history for hypertension, diabetes, hyperlipidemia, and psychiatric disease but could not find a history of menopausal disorders, hormone therapy or LASIK, and dietary habits, including caffeine and supplement use.…”

Section: Discussionmentioning

confidence: 99%

“…The questions and response options were translated into Japanese from the original English, and verified by back-translation into English and comparison with the original (Uchino et al 2011). Twenty-seven participants who responded "yes" to the third question were excluded from the analysis, because their QOL might have been affected by being diagnosed with DED.…”

Section: Questionnairementioning

confidence: 99%

“…In Japan, a large population-based study revealed that the prevalence of clinically diagnosed DED was 2.1% and 7.9% in males and females, respectively, and the percentages with severe symptoms were 11.5% and 18.7% in males and females, respectively (Uchino et al 2011). However, to the best of our knowledge, no study has ever examined the relationship between DED and QOL in non-clinic-based subjects in Japan, whereas DED has been reported to be related to poor QOL and depression in a general population in other countries (Galor et al 2011;Le et al 2012;Wang et al 2012).…”

Section: Introductionmentioning

confidence: 99%

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Dry Eye Disease Is Associated with Deterioration of Mental Health in Male Japanese University Staff

Tounaka

Yuki

Kouyama

et al. 2014

Tohoku J. Exp. Med.

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Dry eye disease (DED) is defined as a multifactorial disease of the tears and ocular surface that results in symptoms of discomfort, visual disturbance, and tear-film instability, with potential damage to the ocular surface. It is thought to be associated with reduced quality of life (QOL). The aim of the present study was to investigate the effects of DED on health-related QOL in Japanese university sedentary office workers who are daily users of visual display terminal. In this study, 163 university staff (99 male and 64 female), aged 23-69 years, served as study subjects. Subjects were asked to answer the following three questions.(1) How often do your eyes feel dry? (2) How often do your eyes feel irritated? (3) Have you ever been diagnosed by a clinician as having dry eye syndrome? Sixty-eight subjects who answered "constantly," "often", or "sometimes" to both questions 1 and 2 were classified as the DED Group, and the remaining 95 were defined as the Non-DED Group. QOL was assessed by the SF-36 questionnaire, which consisted of 36 items to produce three summary scores, namely, mental, physical, and role/social component summary scores. For males, the DED Group had significantly lower scores than the Non-DED Group for mental component summary (MCS) (P = 0.005). In multiple regression analysis, MCS scores were adversely related to DED in males (P = 0.015). DED was associated with worsened QOL. DED should be regarded as a factor that can lead to deterioration of mental health.

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Section: Discussionmentioning

confidence: 99%

Section: Questionnairementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Dry Eye Disease Is Associated with Deterioration of Mental Health in Male Japanese University Staff

Tounaka

Yuki

Kouyama

et al. 2014

Tohoku J. Exp. Med.

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“…Dry eye disease is one of the most common conditions encountered in eye clinics worldwide, with a prevalence ranging from 10.7% to 23.7% in adults [1][2][3]. A retrospective study found that 86% of patients with dry eye disease had meibomian gland dysfunction (MGD), indicating the importance of MGD in this disease [4].…”

Section: Introductionmentioning

confidence: 99%

Additional Instruction by a Nurse Enhanced the Effect of Eyelid Warming on Subjective Symptoms in Patients with Meibomian Gland Dysfunction

T¹,

Ideta²,

Mera³

et al. 2018

J Healthc Commun

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“…4,5 Based on a large population study of DED in Japan, the prevalence of clinical dry eye diagnosis was 2.1% in men and 7.9% in women. 6 Recently, the Japanese Dry Eye Research Society proposed a new dry eye treatment strategy called ''tear film oriented therapy.'' 1 According to this concept, when an abnormality occurs in a tear film layer, the tear film becomes unstable, which can cause DED.…”

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confidence: 99%

The Role of 2% Rebamipide Eye Drops Related to Conjunctival Differentiation in Superoxide Dismutase-1 (Sod1) Knockout Mice

Kojima

Şimşek

Igarashi

et al. 2018

Invest. Ophthalmol. Vis. Sci.

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Citation: Kojima T, Simsek C, Igarashi A, et al. The role of 2% rebamipide eye drops related to conjunctival differentiation in superoxide dismutase-1 (Sod1) knockout mice. Invest Ophthalmol Vis Sci. 2018;59:1675-1681. https://doi.org/10.1167/iovs.17-23213 PURPOSE. The superoxide dismutase-1 knockout (Sod1 À/À ) mouse is an age-related dry eye mouse model. We evaluated the role of 2% rebamipide ophthalmic solution on the conjunctiva and ocular surface alterations in Sod1 À/À mice. METHODS.Rebamipide eye drops (2%) were instilled in six 50-week-old male Sod1 À/À mice and six C57BL/6 strain wild-type (WT) male mice four times a day for 2 weeks. Aqueous tear secretion quantity and tear film breakup time measurements as well as vital stainings were performed. Immunohistochemistry staining of the conjunctiva was performed using SAM pointed domain-containing ETS transcription factor (SPDEF), transglutaminase-1, and involucrin antibodies. Quantitative RT-PCR was carried out to study mRNA expression of the same markers.RESULTS. The mean tear quantities showed no significant changes in both mice strains after treatment (P ¼ 0.24). The mean tear film breakup time (P ¼ 0.003) and vital staining scores significantly improved in the Sod1 À/À mice after treatment. Treatment with 2% rebamipide eye drops significantly decreased the corneal fluorescein (P ¼ 0.0093) and Rose Bengal (P ¼ 0.002) staining scores in the Sod1 À/À mice. We showed a notable increase in SPDEF and a marked decrease in transglutaminase-1 and involucrin immunohistochemistry stainings, together with a significant increase in SPDEF (P ¼ 0.0003) and a significant decline in transglutaminase-1 (P ¼ 0.0072) and involucrin (P ¼ 0.009) mRNA expression after treatment in the Sod1 À/À mice.CONCLUSIONS. Topical use of 2% rebamipide drops was observed to improve conjunctival epithelial differentiation and suppress keratinization in the Sod1 À/À mice.

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Prevalence and Risk Factors of Dry Eye Disease in Japan: Koumi Study

Cited by 248 publications

References 20 publications

Dry Eye Disease Is Associated with Deterioration of Mental Health in Male Japanese University Staff

Dry Eye Disease Is Associated with Deterioration of Mental Health in Male Japanese University Staff

Additional Instruction by a Nurse Enhanced the Effect of Eyelid Warming on Subjective Symptoms in Patients with Meibomian Gland Dysfunction

The Role of 2% Rebamipide Eye Drops Related to Conjunctival Differentiation in Superoxide Dismutase-1 (Sod1) Knockout Mice

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