Prevalence and risk factors of barrett’s esophagus in lynch syndrome

Farha, Natalie; Lyu, Ruishen; Líška, Dávid; Bhatt, Amit; Macaron, Carole; Burke, Carol A.

doi:10.1007/s10689-022-00298-w

Cited by 3 publications

(4 citation statements)

References 13 publications

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“…They were published between 1985 and 2022. Sixteen studies were performed in Asia, 19 – 34 16 in Europe, 35 – 50 14 in America, 51 – 64 and 1 in Oceania. 65 …”

Section: Resultsmentioning

confidence: 99%

“…In detail, only two studies reported the length of hiatal hernia, 58 , 62 and only three studies reported the number of different sized hiatal hernia grouped by different classification criteria in patients with and without BE. 51 , 55 , 56 Therefore, the effect of the size of hiatal hernia on BE could not be explored by subgroup analyses. Sixth, the absence of detailed information on the type of hiatal hernia prevented from further analysis regarding the association between subtypes of hiatal hernia and BE.…”

Section: Discussionmentioning

confidence: 99%

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Association between hiatal hernia and Barrett’s esophagus: an updated meta-analysis with trial sequential analysis

Ma,

Tong,

et al. 2024

Therap Adv Gastroenterol

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Background: Barrett’s esophagus (BE) is a precursor of esophageal adenocarcinoma. It is critical to recognize the risk factors associated with BE. Objectives: The present meta-analysis aims to systematically estimate the association of hiatal hernia with the risk of BE. Design: A meta-analysis with trial sequential analysis. Data sources and methods: The PubMed, EMBASE, and Cochrane Library databases were searched. The pooled odds ratios (ORs) and adjusted ORs (aORs) with their 95% confidence intervals (CIs) were calculated for the combined estimation of unadjusted data and data adjusted for confounders, respectively. Heterogeneity was quantified using the Cochrane Q test and I² statistics. Subgroup, meta-regression, and leave-one-out sensitivity analyses were employed to explore the sources of heterogeneity. Results: Forty-seven studies with 131,517 participants were included. Based on the unadjusted data from 47 studies, hiatal hernia was significantly associated with an increased risk of any length BE (OR = 3.91, 95% CI = 3.31–4.62, p < 0.001). The heterogeneity was significant ( I² = 77%; p < 0.001) and the definition of controls ( p = 0.014) might be a potential contributor to heterogeneity. Based on the adjusted data from 14 studies, this positive association remained (aOR = 3.26, 95% CI = 2.44–4.35, p < 0.001). The heterogeneity was also significant ( I² = 65%; p < 0.001). Meta-analysis of seven studies demonstrated that hiatal hernia was significantly associated with an increased risk of long-segment BE (LSBE) (OR = 10.01, 95% CI = 4.16–24.06, p < 0.001). The heterogeneity was significant ( I² = 78%; p < 0.001). Meta-analysis of seven studies also demonstrated that hiatal hernia was significantly associated with an increased risk of short-segment BE (OR = 2.76, 95% CI = 2.05–3.71, p < 0.001). The heterogeneity was not significant ( I² = 30%; p = 0.201). Conclusion: Hiatal hernia should be a significant risk factor for BE, especially LSBE. Registration: PROSPERO registration number CRD42022367376.

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“…They were published between 1985 and 2022. Sixteen studies were performed in Asia, 19 – 34 16 in Europe, 35 – 50 14 in America, 51 – 64 and 1 in Oceania. 65 …”

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Association between hiatal hernia and Barrett’s esophagus: an updated meta-analysis with trial sequential analysis

Ma,

Tong,

et al. 2024

Therap Adv Gastroenterol

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“…5,6 On the basis of the currently available data, patients with LS do not appear to have an increased risk of BE when compared with the general population, but further studies are needed. 23 Although esophageal adenocarcinoma (EAC) is not typically associated with LS, 3 cases of LS-related EAC have been reported. [24][25][26] Because there is limited data published on the prevalence of BE and EAC in LS, cohort studies should report its presence in future publications.…”

Section: Esophagusmentioning

confidence: 99%

“…The prevalence of BE in LS is reported between 3.2% and 6.5%; however, it has only been reported in 2 studies of LS-related EGD surveillance 5,6. On the basis of the currently available data, patients with LS do not appear to have an increased risk of BE when compared with the general population, but further studies are needed 23. Although esophageal adenocarcinoma (EAC) is not typically associated with LS, 3 cases of LS-related EAC have been reported 24–26.…”

Section: Introductionmentioning

confidence: 97%

The Approach to Performance of Quality Upper Endoscopy in Lynch Syndrome (QUELS)

Farha¹,

Kumar

Katona

et al. 2022

Journal of Clinical Gastroenterology

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Strong evidence demonstrates the protective benefit of frequent colonoscopy surveillance for colorectal cancer prevention in Lynch Syndrome (LS) and is endorsed by many guidelines. Until recently, the evidence supporting the utility of upper endoscopy [esophagogastroduodenoscopy (EGD)] for upper gastrointestinal (UGI) cancer surveillance was limited. Over the last 3 years, multiple studies have demonstrated that EGD surveillance in LS is associated with the detection of both precancerous lesions and earlystage UGI cancers. On the basis of the emerging favorable evidence derived from EGD surveillance programs, the 2022 National Comprehensive Cancer Network (NCCN) Guidelines for LS recommend UGI surveillance with EGD starting between age 30 and 40 years with repeat EGDs every 2 to 4 years, preferably in conjunction with colonoscopy, in all patients with a germline pathogenic variant (PV) in MLH1, MSH2, EPCAM, and MSH6 and, because of the lack of data, consideration in PMS2. Standardization of the approach to performing EGD surveillance in LS and reporting clinically actionable findings is requisite for both improving quality and understanding the cost efficiency and outcomes of patients undergoing EGD as a surveillance tool. Accordingly, the primary objective of this Quality of Upper Endoscopy in Lynch Syndrome (QUELS) statement is to articulate a framework for standardizing the approach to performing and reporting EGD findings in patients with LS by introducing emerging quality metrics. The recommendations presented herein were developed from available evidence and consensus-based expert opinion and provide a practical approach for clinicians applying EGD surveillance in accordance with the most recent and existing LS guidelines.

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Prevalence of Barrett’s Esophagus and Esophageal Adenocarcinoma With and Without Gastroesophageal Reflux: A Systematic Review and Meta-analysis

Saha,

Vantanasiri,

Mohan

et al. 2024

Clinical Gastroenterology and Hepatology

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Prevalence and risk factors of barrett’s esophagus in lynch syndrome

Cited by 3 publications

References 13 publications

Association between hiatal hernia and Barrett’s esophagus: an updated meta-analysis with trial sequential analysis

Association between hiatal hernia and Barrett’s esophagus: an updated meta-analysis with trial sequential analysis

The Approach to Performance of Quality Upper Endoscopy in Lynch Syndrome (QUELS)

Prevalence of Barrett’s Esophagus and Esophageal Adenocarcinoma With and Without Gastroesophageal Reflux: A Systematic Review and Meta-analysis

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