Prevalence and Risk Factors of Acute Incidental Infarcts

Saini, Monica; Suministrado, Ma Serrie P; Hilal, Saima; Dong, Yan; Venketasubramanian, Narayanaswamy; Ikram, M. Kamran; Chen, Christopher

doi:10.1161/strokeaha.115.009963

Cited by 21 publications

(20 citation statements)

References 23 publications

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“…9–12 These lesions have also been identified in 15% of patients with cerebral amyloid angiopathy and recent intracerebral haemorrhage, 13 6% of patients with ischaemic stroke, 14 14% of patients after carotid endarterectomy, 15 and 1–4% of patients with cognitive impairment or dementia. 16,17 …”

Section: Detection Of Microinfarctsmentioning

confidence: 99%

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Detection, risk factors, and functional consequences of cerebral microinfarcts

Veluw

Shih

Smith

et al. 2017

The Lancet Neurology

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Cerebral microinfarcts are small lesions that are presumed to be ischaemic. Despite the small size of these lesions, affected individuals can have hundreds to thousands of cerebral microinfarcts, which cause measurable disruption to structural brain connections, and are associated with dementia that is independent of Alzheimer’s disease pathology or larger infarcts (ie, lacunar infarcts, and large cortical and non-lacunar subcortical infarcts). Substantial progress has been made with regard to understanding risk factors and functional consequences of cerebral microinfarcts, partly driven by new in-vivo detection methods and the development of animal models that closely mimic multiple aspects of cerebral microinfarcts in human beings. Evidence from these advances suggests that cerebral microinfarcts can be manifestations of both small vessel and large vessel disease, that cerebral microinfarcts are independently associated with cognitive impairment, and that these lesions are likely to cause damage to brain structure and function that extends beyond their actual lesion boundaries. Criteria for the identification of cerebral microinfarcts with in-vivo MRI are provided to support further studies of the association between these lesions and cerebrovascular disease and dementia.

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Section: Detection Of Microinfarctsmentioning

confidence: 99%

“…In a population-based study of 793 participants aged 40–75 years, no incidental diffusion-weighted imaging lesions were found (95% confidence upper limit 0·5%), 18 whereas in a community-based study of 623 older individuals (mean age 71 years) with more vascular risk factors, the prevalence was 1%. 17 …”

Section: Detection Of Microinfarctsmentioning

confidence: 99%

Detection, risk factors, and functional consequences of cerebral microinfarcts

Veluw

Shih

Smith

et al. 2017

The Lancet Neurology

Self Cite

240

277

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“…A distinction should be made regarding clinically silent infarcts (acute incidental infarcts, AII) [36]. The prevalence of AII infarcts lies between 8 -28 % [36] and increases with age. In DWI they appear as hyperintense lesions with corresponding signal reduction on the ADC card (• ▶ Fig.…”

Section: Strokementioning

confidence: 99%

“…Most cases of AII are not asymptomatic, but the symptoms described by the patient are not perceived as a stroke by relatives; consequently there is no medical follow-up [37]. Since both a transient ischemic attack (TIA) with a DWI-positive lesion as well as an AII increase the risk of a subsequent stroke [36], they represent an incidental finding requiring immediate investigation (Category III).…”

Section: Strokementioning

confidence: 99%

Management of Intracranial Incidental Findings on Brain MRI

Langner

Buelow

Fleck

et al. 2016

Fortschr Röntgenstr

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The wider use of MRI for imaging of the head in both research and clinical practice has led to an increasing number of intracranial incidental findings. Most of these findings have no immediate medical consequences. Nevertheless, knowledge of common intracranial incidental findings and their clinical relevance is necessary to adequately discuss the findings with the patient. Based on the author?s experiences from a large population-based study, the most common incidental MR findings in the brain will be presented, discussing their clinical relevance and giving recommendations for management according to the current literature and guidelines. Key points: ??Intracranial incidental findings are common. ??The majority of these findings have no immediate medical consequences. ??Knowledge of common incidental findings is necessary for appropriate management. Citation Format: ??Langner S, Buelow R, Fleck S et?al. Management of Intracranial Incidental Findings on Brain MRI. Fortschr R?ntgenstr 2016; 188: 1123???1133

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“…Acute cerebral infarction is a common cardiovascular and cerebrovascular disease in China, which has high fatality rate, disability rate and recurrence rate [1][2][3]. Anti-platelet, anticoagulant and lipid-lowering therapies are the conventional treatments of acute cerebral infarction, which have the preventive effect on both the occurrence and recurrence of cerebral infarction.…”

Section: Introductionmentioning

confidence: 99%