Prevalence and risk factors of oral HPV infection among a healthy Iranian population; Kurdistan, West of Iran

Zargaran, Massoumeh; Jalilian, Farid Azizi

doi:10.1002/jmv.26356

Cited by 3 publications

(9 citation statements)

References 29 publications

(94 reference statements)

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“…In the 20–39 and 40–59 age groups, the presence of oral HPV may be caused by sexual activity. Similar to our data, studies in other countries have found that the age group around or over the age of 60 has the highest HPV presence in the oral cavity [ 6 , 19 , 20 ]. For adults over the age of 60, the number of positive oral HPV cases may be associated not only with sexual habits, but also with decreased immunity.…”

Section: Discussionsupporting

confidence: 92%

“…Oral HPV infections are the result of sexual behavior; however, recent evidence suggests a possible mouth-to-mouth transmission through saliva [ 3 ]. The presence of HPV genotypes in the oral cavity in various studies has been estimated up to 20% [ 6 , 13 , 14 , 15 , 16 , 17 , 18 ]. In our study, the incidence of HPV was low and amounted to 11.5% (53/461).…”

Section: Discussionmentioning

confidence: 99%

“…In our study, as in many others, the presence of HPV in the oral cavity was higher in males than in females [ 20 , 21 , 22 , 23 , 24 ]. This may be justified by the fact that biological and behavioral differences may increase the sensitivity of men to HPV infection [ 6 ].…”

Section: Discussionmentioning

confidence: 99%

“…These types are associated with head and neck, cervical and anogenital tumors. Among the high-risk types, HPV 16 and HPV 18 are the most common genotypes found in all HPV-related cancers [ 1 , 2 , 6 ]. HPV can induce carcinogenic transformation of infected mucosal epithelium by E6 and E7 oncoproteins, which inhibit p53 and pRB tumor suppressors [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

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Prevalence of Human Papillomavirus (HPV) in the Oral Cavity of a Healthy Population in South-Eastern Poland

Koleśnik

Stępień

Polz‐Dacewicz

2022

IJERPH

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Human papillomavirus (HPV) is associated with both benign lesions and with neoplastic diseases, such as oropharyngeal cancer. Due to the increasing occurrence of these neoplasms on a global scale, it seems important to estimate the risk factors in the population. So far, data on the presence of oral HPV in the European population are scarce. Oral HPV was detected in 53 out of 461 healthy subjects (11.5%) in south-eastern Poland. Among the most common oncogenic types, HPV 16 was reported in four subjects (0.87%) and HPV 18 in three subjects (0.65%). Another high-risk type, HPV 45, was detected in nine subjects (1.95%). Low risk types (HPV 6, 11, 54) were detected in 25 cases, which constituted 5.4% of all tested samples. In adults and children, statistically more HPV positive cases have been reported in males than in females. A positive relationship was demonstrated between age and the amount of positive oral HPV. The presence of HPV was statistically more frequent in the population living in urban rather than in rural areas in all studied age groups (p < 0.05).

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Prevalence of Human Papillomavirus (HPV) in the Oral Cavity of a Healthy Population in South-Eastern Poland

Koleśnik

Stępień

Polz‐Dacewicz

2022

IJERPH

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“…Moreover, the use of vitamin C and carotenoids can be used to decrease the HPV infection persistence. 14,30 In the oral cavity, smoking affects the immunological functions, including innate and adaptive immune responses. 5 The acquisition and persistence of HPV infection increases in the individuals who use tobacco, as it might inhibit the immune function and causes direct damage to the cells.…”

Section: Resultsmentioning

confidence: 99%

Molecular characterization and risk factors of oral high‐risk human papillomavirus among females in Punjab, Pakistan

Minhas

Kashif²,

Rehman³

et al. 2022

Journal of Medical Virology

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Background The development of oral and oropharyngeal cancers is associated with human papillomavirus (HPV) infection. However, debate exists about the prevalence of high‐risk oral HPV (HR‐HPV) and its associated risk factors. This study evaluated the distribution of genotypes and associated risk factors of oral HR‐HPV infection in the normal oral mucosa of the Pakistani female population with general gynecological problems. Methods A total of 200 females from a regional gynecological hospital in Pakistan were included in this cross‐sectional study. A self‐administered questionnaire was carried out, followed by the study participants' oral and dental examinations. Whole saliva was collected by a drooling method. The viral DNA extraction and oral HR‐HPV genotyping were detected via real‐time polymerase chain reaction. Results Among the 200 females (mean age, 37.76 years), 22 females (11%) were positive for oral HR‐HPV DNA. Single oral HR‐HPV infection was seen in 8%, whereas co‐infection was observed in 3% with HPV16 and HPV18 most common genotypes. Comparison of the risk factors like oral sex history odds ratio (OR 8.21, 95% confidence interval [CI] 1.85–28.16; p < 0.005), and open‐mouth kissing (OR, 5.17; 95% CI 1.48–27.41; p = 0.005) with oral HR‐HPV infection was found to be significantly associated. Conclusion In Pakistan, oral HR‐HPV‐positive infection is not uncommon; HPV16 and HPV18 are the most frequent genotypes. Furthermore, this study also provides data that oral HR‐HPV positive infection was significantly associated with sexual behaviors. Therefore, preventive health efforts, like health education and vaccination, should be practiced.

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Prevalence of Human Papilloma virus in potentially malignant oral disorders is a risk factor for development of early dysplasia-A cytological investigation

Javed,

Anjum,

Zulifqar

et al. 2023

Pak J Med Sci

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Objective: The proposed study was planned to screen Human Papilloma Virus (HPV) status in potentially malignant oral disorders (PMOD) and correlated HPV positivity with cytological changes in oral smears. Methods: This descriptive cross-sectional study was conducted at University of Health Sciences Lahore, Pakistan from April 2020 to April 2021. Oral smears from N=162 patients with PMODs were taken by the Cytobrush and Manual Liquid Based Cytology was performed followed by p16 antibody detection on immunohistochemistry and HPV-DNA detection by conventional polymerase chain reaction (PCR). The cytological changes were categorized according to the updated Bethesda Classification system 2014. SPSS was used to analyze data and p-Value of <0.05 was considered as statistically significant. Results: Out of total N = 162 patients, the most prevalent lesion [39% (n=63)] was lichen planus. Fifty six percent (n=90) of the patients were habitual chewers and 43% (n=70) were smokers. Pap staining of oral smears revealed atypical squamous cells of undetermined significance (ASCUS) in 45% (n=69) cases and in 2 % (n=4) of the samples diagnosis of atypical squamous cells-cannot exclude high-grade squamous intraepithelial lesion (ASC-H) was made. A total of 37% cases showed HPV positivity by polymerase chain reaction (PCR) while positive p16 expression was observed in 24% of the cases. ASC-H and ASCUS category showed significant association with HPV positivity (p=0.003). Conclusion: Early detection of PMODs by adopting minimally invasive cytological techniques and screening for HPV infection in local population is pivotal to reduce the morbidity and mortality associated with the advanced disease and carcinoma. doi: https://doi.org/10.12669/pjms.40.1.7532 How to cite this: Javed M, Anjum R, Zulifqar G, Rasheed F, Amar A, Naseem N. Prevalence of Human Papilloma virus in potentially malignant oral disorders is a risk factor for development of early dysplasia-A cytological investigation. Pak J Med Sci. 2024;40(1):---------. doi: https://doi.org/10.12669/pjms.40.1.7532 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Prevalence and risk factors of oral HPV infection among a healthy Iranian population; Kurdistan, West of Iran

Cited by 3 publications

References 29 publications

Prevalence of Human Papillomavirus (HPV) in the Oral Cavity of a Healthy Population in South-Eastern Poland

Prevalence of Human Papillomavirus (HPV) in the Oral Cavity of a Healthy Population in South-Eastern Poland

Molecular characterization and risk factors of oral high‐risk human papillomavirus among females in Punjab, Pakistan

Prevalence of Human Papilloma virus in potentially malignant oral disorders is a risk factor for development of early dysplasia-A cytological investigation

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