Prevalence and risk factors of myasthenia gravis recurrence post-thymectomy

Alqarni, Fatmah; Almalki, Daifallah; Aljohani, Ziyad; Ali, Adel A.; AlSaleem, Alanood; Alotaibi, Noura; Odeh, Shahla; Dalbhi, Sultan Al

doi:10.17712/nsj.2021.1.20190041

Cited by 10 publications

(6 citation statements)

References 88 publications

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“…La miastenia gravis al ser considerada una enfermedad autoinmune provoca una afección en la unión neuromuscular, diagnosticada frecuentemente en personas jóvenes y aquellas del sexo femenino, produciendo un deterioro paulatino en la calidad de vida de estos pacientes, clínicamente la miastenia se presenta como una condición heterogénea caracterizada por un patrón de debilidad muscular enfocadas en ciertas estructuras, a nivel ocular, respiratorio, bulbar, a nivel del tronco y extremidades. (7) La participación del timo en la miastenia gravis se puede manifestar por la producción de anticuerpos para el receptor de acetilcolina y para los anticuerpos Musk. Aproximadamente el 60% de los pacientes no manifiestan síntomas asociados al timoma y un menor refiere como el síntoma más común el dolor generado por el efecto de masa.…”

Section: Discussionunclassified

Eficacia de la timectomía en pacientes diagnosticados con miastenia gravis timomatosa y no timomatosa

2022

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Introducción: La Miastenia Gravis (MG) es considerada una enfermedad de carácter autoinmune, presentando anticuerpos que actuarán contra los receptores de la acetilcolina provocando una insuficiencia en la transmisión neuromuscular y se manifiesta por una debilidad o fatigabilidad de los músculos esqueléticos, se ha visto relacionada con patología de la glándula tímica observándose así alteraciones de dicho órgano como la hiperplasia y el timoma. Dentro del tratamiento quirúrgico, la timectomía está indicada en pacientes con timoma, la cual consiste en la extirpación total del timo con la grasa peritímica. Objetivo General: Analizar la eficacia de la timectomía en pacientes diagnosticados con miastenia gravis timomatosa y no timomatosa mediante una revisión sistemática. Metodología: Se realizó una revisión sistemática, siendo este de tipo Descriptivo – Analítico. en base a la consulta del material bibliográfico. Resultados: Los artículos analizados indican que la Timectomía proporciona buenos resultados en el tratamiento de la MG timomatosa y no timomatosa, la remisión de los pacientes puede variar de acuerdo con factores como la edad, el tiempo transcurrido entre la cirugía y la valoración postoperatoria y el lapso de tiempo del diagnóstico de la enfermedad.

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Section: Discussionunclassified

Eficacia de la timectomía en pacientes diagnosticados con miastenia gravis timomatosa y no timomatosa

2022

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“…The treatment of acute myasthenic crisis consists of the administration of rapid immunotherapy with immunoglobulins administered intravenously, or by using plasmapheresis. During this time, patients should be evaluated for possible infection or other complications, such as the use of medications that may exacerbate MG attacks [ 84 ].…”

Section: Postoperative Follow-up Of Thymectomized Patientsmentioning

confidence: 99%

Thymus Surgery Prospectives and Perspectives in Myasthenia Gravis

Salahoru,

Grigorescu,

Hinganu

et al. 2024

JPM

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The thymus is a lymphoid organ involved in the differentiation of T cells, and has a central role in the physiopathogenesis of Myasthenia Gravis (MG). This connection is proved by a series of changes in the level of neuromuscular junctions, which leads to a decrease in the amplitude of the action potential in the post-synaptic membrane. Because of this, the presence of anti-cholinergic receptor antibodies (AChR), characteristic of MG, is found, which causes the progressive regression of the effect of acetylcholine at the level of neuromuscular junctions, with the appearance of muscle weakness. The thymectomy is a surgical variant of drug therapy administered to patients with MG. In the case of patients with nonthymomatous MG, thymectomy has become a therapeutic standard, despite the fact that there is no solid scientific evidence to explain its positive effect. Videothoracoscopic surgery or robotic surgery led to a decrease in the length of hospital stay for these patients. This paper aims to synthesize the information presented in the literature in order to create a background for the perspectives of thymectomy.

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“…Patients with MG who exhibited both AChR antibodies and thymic hyperplasia fared best after undergoing thymectomy [18] . However, it appears that the absence of serum antibodies does not rule out a positive response to thymectomy [19] , Despite the fact that this is still up for debate.…”

Section: Thymectomymentioning

confidence: 99%

An Overview of Thymectomy Approaches among Myasthenia Graves Patients: Review Article

Desoky¹,

Emam²,

Ragab³

et al. 2023

The Egyptian Journal of Hospital Medicine

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Background: Myasthenia gravis (MG) is a syndrome characterized by fatigue-and activity-induced improvements in skeletal muscular weakening. There is a wide range of possible involvement, including but not limited to the muscles of the eyes, face, oropharynx, trunk, and limbs. Once the patient's level of weakness has been managed to the point that surgery is possible, thymectomy is recommended. Preoperatively, patients are typically treated with mild doses of intravenous immunoglobulins as well as glucocorticoids. Objective: Review of the literature on thymectomy approaches among myasthenia graves' patients. Methods: We scoured medical journals and databases including PubMed, Google Scholar, and Science Direct for information on thymectomy and myasthenia graves. Between September 2006 and August 2022, however, only the latest or most comprehensive study was considered. The authors also assessed the usefulness of references drawn from similar books. Documents written in languages other than English have been overlooked because of lack of funding to translate them. Unpublished articles, oral talks, conference abstracts, and dissertations were all generally agreed upon not to constitute valid scientific investigation. Conclusion: It has been argued that a maximum thymectomy, in which both the transsternal and transcervical techniques are used on the same MG patient, yields superior results. After extensive transsternal thymectomy or video-assisted thoracoscopic thymectomy, half of patients with non-thymomatous MG had complete stable remissions at 6 years of follow-up.

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Prevalence and risk factors of myasthenia gravis recurrence post-thymectomy

Cited by 10 publications

References 88 publications

Eficacia de la timectomía en pacientes diagnosticados con miastenia gravis timomatosa y no timomatosa

Eficacia de la timectomía en pacientes diagnosticados con miastenia gravis timomatosa y no timomatosa

Thymus Surgery Prospectives and Perspectives in Myasthenia Gravis

An Overview of Thymectomy Approaches among Myasthenia Graves Patients: Review Article

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