Prevalence and risk factors of vertebral fractures in women with rheumatoid arthritis using vertebral fracture assessment

Abstract

RA is a risk factor on its own for the development of osteoporosis and VFs and this risk increases more with low weight, disease duration and severe course of disease. These findings may suggest that to prevent the development of VFs, precautions should be taken immediately to suppress the disease activity and correct the weight loss in patients with RA.

Biological agents and fracture risk

“…[7] опреде-лили, что РА является фактором риска переломов и деформаций позвонков: в группе женщин с РА в постменопаузе частота де-формации позвонков составила 30% против 7% в группе контро-ля (p<0,05); A. El Maghraoui и соавт. [8] установили, что этот риск возрастает в связи с потерей массы тела, увеличением длитель-ности и активности заболевания. Кроме того, в недавнем иссле-довании S. Brennan и соавт.…”

Rheumatoid Cachexia, a Metabolic Rheumatoid Arthritis Disorder: Pathophysiological Mechanisms, Diagnostic Tools and Current Therapeutic Strategy

“…Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease of unknown etiology that is associated with reduced life expectancy and causes destruction of joint cartilage and bone [1,2]. It affects nearly 1% of the population and predominates among women [3].…”

Risk Factors of Osteoporosis in Rheumatoid Arthritis Patients; Glucocorticoid, Inactivity, or Nutrient Deficiencies

“…In addition, pain and loss of joint function caused by the disease activity and deformity can result in inactivity, further increasing osteoporosis risk [1,2]. Some studies also show that bone loss in RA may occur as a direct result of the disease [3]. In addition to the factors described above, there are a number of traditional risk factors for fracture that are not specific to RA because onset of RA tends occur later in life of women, with a peak around the age of menopause.…”