Prevalence and Risk Factors of Prolonged Corrected QT Interval Among Children and Adolescents Treated With Antipsychotic Medications

Abstract

Patients should undergo a baseline ECG assessment before starting AP medication treatment, particularly patients with concomitant use of attention deficit and hyperactivity disorder drugs or a family/personal history of heart disease.

Effects of atypical antipsychotic drugs on QT interval in patients with mental disorders

“…Quetiapine was examined in two systematic reviews and meta-analyses (38,80). We also identified published and unpublished data from 7 RCTs and 4 non-randomized studies (21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(81)(82)(83)(84)(85)(86).…”

“…Novel technology applications and adequate statistical methods should be used for routine analysis of antipsychotic-induced QT prolongation and cardiac arrhythmias. [71] Female [38], Male [26] 20+ [49], <20 [2] Risperidone Electrocardiogram QT corrected interval prolonged [43] Female [23], Male [20] 20+ [26], <20 [4] Ziprasidone Hydrochloride Torsade de pointes [83] Female [61], Male [19] 20+ [57] Ziprasidone Hydrochloride…”

Malignant Ventricular Arrhythmias Resulting From Drug-Induced QTc Prolongation: A Retrospective Study

“…Indeed, several drugs involved in the so-called diLQTS have recognized capacities to act on arrhythmogenesis (in particular, a marked antiarrhythmic effect is held by drugs of class I and III of the Vaughan Williams classification) [ 6 - 7 ]. However, in genetically predisposed subjects, also drugs primarily used for non-cardiac diseases, in particular neuroleptic drugs [ 8 ], antidepressants [ 9 ], antimicrobials [ 10 ] and prokinetic agents for high gastrointestinal tract’s motility disorders [ 11 ] have been shown to be able to elicit diLQTS. In general, it is reasonable to affirm that QT prolongation is constantly connected to disturbances of ionic homeostasis inside the myocytes [ 5 ], that imply their exposure to increased risk of hyperkinetic arrhythmic desynchronization phenomena that may result in polymorphic, i.e.…”

Patient, Treatment, and Health Care Utilization Variables Associated with Adherence to Metabolic Monitoring Practices in Children and Adolescents Taking Second-Generation Antipsychotics

“…20 SGAs are also known to cause cardiac arrhythmias such as QTc interval prolongation, a risk for potentially life-threatening ventricular arrhythmias. 29 Although weight gain is a normal part of growth and development, influenced by critical periods, including adiposity rebound (between 3 and 7 years) and puberty (between 11 and 15 years for girls and 13 and 17 years for boys), multiple studies have demonstrated that children and adolescents initiated on SGAs can experience clinically significant weight gain of at least 7% of baseline body weight. [30][31][32] This is greater and faster weight gain than reported in adult populations.…”