Prevalence and risk factors of erectile dysfunction among chronic hepatitis C male patients treated with pegylated interferon-α and ribavirin

Fawzy, Nagy; Atia, Hesham; Galal, Sherif; Shawky, Jihan A

doi:10.4103/1110-1105.153776

Cited by 6 publications

(5 citation statements)

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“…It was also observed that sexual dysfunction was reported in patients following pegylated interferon and ribavirin therapy. It was suggested that interferon may have a direct impact on the gonads decreasing testosterone production or an indirect psychological influence inducing the partial impairment of sexual desire and satisfaction [11].…”

Section: N Discussionmentioning

confidence: 99%

“…A study has reported a similarly high prevalence of sexual dysfunction in patients with chronic HCV compared with healthy controls and attributed these to multiple factors, including depressive symptoms and antidepressant use [20]. It was previously proposed that IFN-RBV therapy associated with sexual impairment could be secondary to depression, decreased testicular testosterone production, or viral effects on the pathophysiologic mechanism of erection [11]. Recent studies have suggested that therapy with new DAAs is associated with improvement of male sexual function [12,21].…”

Section: N Discussionmentioning

confidence: 99%

“…The negative impact of HCV infection on sexual function is associated with a poor quality of life (QoL) [10]. Sexual dysfunction was observed to be an infrequent side effect of pegylated interferon and ribavirin therapy [11]. The literature suggests that DAA can improve erectile function in patients with HCV [12].…”

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confidence: 99%

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Impact of sofosbuvir/ledipasvir versus sofosbuvir/daclatasvir regimens on the male sexual function of patients with chronic hepatitis C

2021

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Direct-acting antivirals (DAAs) are associated with remarkable efficiency and safety profiles; however, their effect on erectile function remains insufficiently studied. This study included 200 male patients with chronic hepatitis C virus (HCV) infection divided into groups A and B and 100 healthy controls. Group A received sofosbuvir (SOF) 400 mg/ledipasvir 90 mg (Harvoni), whereas group B received SOF 400 mg/ daclatasvir 60 mg for 3 months. The Arabic version of the five-item International Index of Erectile Function-5 (IIEF-5) questionnaire was used to assess erectile function before and after completion of therapy and 3 months after. Erectile dysfunction (ED) was present in 74.5% of the patients and 14% of the con-SUMMARY trols. Immediately after treatment, group B (22.5±2.6) had a significantly higher mean IIEF-5 score than did group A (17.3±3.3) (p<0.001). Three months after treatment, all groups had no significant differences in mean IIEF-5 scores (group A: 23.1±1.9, group B: 23.3±1.9, controls: 23.7±2.3); however, free testosterone (FT) levels were significantly higher compared with pre-treatment. Both treatment regimens were associated with the improvement of erectile function and sex hormonal milieu. SOF/daclatasvir was associated with earlier improvement of erectile function compared with SOF/ledipasvir.

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Section: N Discussionmentioning

confidence: 99%

Section: N Discussionmentioning

confidence: 99%

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Impact of sofosbuvir/ledipasvir versus sofosbuvir/daclatasvir regimens on the male sexual function of patients with chronic hepatitis C

2021

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“…found that patients affected by HCV treated with recombinant human interferon alfa-2b, alone or in a combination with ribavirin, developed an overall increase in depressive state during the treatment, with a proportional increase in loss of libido. Furthermore, another research group reported significant decline in sexual function at week 12 of combination treatment that gradualy improved within 48 weeks after treatment [27].…”

Section: Benhamentioning

confidence: 98%

Effect of Female Chronic Hepatitis C Virus on Her Male Partner Sexual Function

Saleh

Hamed

Omer

2018

Benha Journal of Applied Sciences

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Human sexuality is the way people express themselves as sexual beings. This involves biological, erotic, physical, emotional, social or spiritual feeling and behaviors. Sexual dysfunction refers to a problem occurring during any phase of the sexual response cycle that prevents the individual or couple from experiencing satisfaction during the sexual activity . The aim of this work is to assess the sexual function of the male partners of females with chronic hepatitis c virus. This was a cross sectional study that was conducted on 100 males (<45 years old) married to sexually active female partners having chronic hepatitis C (group A) and 100 age matched males married to healthy individuals as control (group B) all subjects were recruited from Banha University Hospital (hepatology unit) and National Liver Institute at EL-Menofia during the period from January 2017 to December 2018. Data was collected using the International Index of Erectile Function (IIEF) questionnaire. we noticed that males married to female partners who receive treatment of HCV had high scores of sexual functions than males married to untreated female partners regarding to all items of sexual domains of IIEF (p < 0,001). The results of this study provide quantifiable risk information for counseling long-term monogamous heterosexual couples in which one partner has chronic HCV infection. In addition to the extremely low estimated risk for HCV infection in sexual partners, the lack of association with specific sexual practices provides unambiguous and reassuring counseling messages.

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“…Sexual dysfunction is the most frequently encountered side effect of many antidepressant medications used to treat the depression and anxiety associated with combination treatment for HCV. (17) Accordingly; they may have bad relationships with their family or be isolated from society because of physical tiredness or feelings of powerlessness. As such, Chronic HC is originated to widely affect the patients' personal and family lives and even the society at large, representing that efforts are desired to recover their Health-related quality of life (HRQOL) (14) The Health-related quality of life is a concept that refers to the effects of health on the quality of life.…”

Section: Introductionmentioning

confidence: 99%

Impact of Interactive Digital-Based Hepatitis C Education on Self-Management and Quality of Life of Damanhour University Students Having Hepatitis C.

2019

JHMN

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Background: Chronic hepatitis C virus (HCV) infection is a major public health crisis and currently is the most frequent cause of liver related morbidity and mortality which caused 1.34 million deaths in 2015 globally. Infected individuals experience a variety of physical and psychological symptoms, functional limitations and impaired quality of life as a result of having HCV. Aim of study: is to assess the impact of Interactive Digital-Based Hepatitis C Education on Self-Management and Quality of Life of Damanhour University Students Having Hepatitis C. Hypothesis: University students having Hepatitis C who engage in interactive digital-Based Hepatitis C education demonstrate greater improvement in Self-Management and quality of life than those who are not. Material and Methods: Quasi-experimental pre/post-test research design. Settings: The study was carried out in the medical health insurance clinic affiliated to Damanhour University. Subjects: the total sample was 36 students having Hepatitis C. Tools: Data was collected through using students' knowledge about HCV Structured Questionnaire Sheet, Generic health-Related Quality Of Life Scale, Disease-Specific Health-Related Quality Of Life questionnaire, Hepatitis C Self-Management Profile Scale and Satisfaction with Interactive Digital-Based Hepatitis C educational program scale. Results: More than half of the intervention group (55.6%) aged more than 20 years with a mean age of 20.9±2.01 years, and more than one third of the control group (38.9%) with a mean age of 19.4±2.17 years. Above two thirds of the intervention and control groups, (66.7%, and 50.0% respectively) were males. Social networks and Websites, reported as the main source of information about hepatitis C by less than half of the intervention group (44.4%), and more than two thirds of the control group (66.7%). Only 11.1% of the intervention group had good knowledge level at pre program, with mean score of 7.08±3.01 compared to less than two thirds of them (61.1%) in post program. Significant differences was observed between intervention group at pre and 3 months post program implementation (t1=4.25, P=0.002). Interactive Digital-Based Education showed a significant impact on the intervention group's practices in different areas of Hepatitis C self-management. It is evident that, statistical significant correlation was found between intervention group's satisfaction with the program and total score of self-management practices and quality of life in post program. Conclusion and Recommendations: Interactive Digital-Based Education on Self-Management of Hepatitis C had positive impact on HCV outcomes including improvement in Hepatitis C knowledge, self-management practices and quality of life. In addition, it plays a significant role in improving Hepatitis C control, and motivates the students to adopt healthy lifestyle. The overall results revealed that, university students' satisfaction with Interactive Digital-Based Hepatitis C educational program was high. Therefore, use interactive technolog...

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Prevalence and risk factors of erectile dysfunction among chronic hepatitis C male patients treated with pegylated interferon-α and ribavirin

Cited by 6 publications

References 0 publications

Impact of sofosbuvir/ledipasvir versus sofosbuvir/daclatasvir regimens on the male sexual function of patients with chronic hepatitis C

Impact of sofosbuvir/ledipasvir versus sofosbuvir/daclatasvir regimens on the male sexual function of patients with chronic hepatitis C

Effect of Female Chronic Hepatitis C Virus on Her Male Partner Sexual Function

Impact of Interactive Digital-Based Hepatitis C Education on Self-Management and Quality of Life of Damanhour University Students Having Hepatitis C.

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