Prevalence and Risk Factors of Potential Drug Interactions in Hospitalized Cardiovascular Patients Using Three Knowledge Bases

Raslan, H. Y.; Hassan, Aslinda; El-Mahdy, M.; El-Faham, T. H.

doi:10.9734/jamps/2018/44526

Cited by 1 publication

(7 citation statements)

References 29 publications

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“…Authors of the Serbian study revealed a positive association between having an infectious or respiratory diseases and the presence of pDDIs [ 14 ]. Age did not have an effect on the presence of pDDIs as reported in three previous studies [ 7 , 16 , 17 ], which was consistent with our findings. The same factor did have an effect per three other studies [ 12 , 13 , 24 ].…”

Section: Discussionsupporting

confidence: 94%

“…When it comes to the influence of comorbidities on the pDDI prevalence, the results were conflicting. Similar to our findings, the number of comorbidities did not affect the prevalence of pDDIs as reported in two previous studies [ 7 , 16 ]. Three other studies found that the presence of comorbidities was a significant predictor for the prevalence of pDDIs [ 11 , 14 , 17 ].…”

Section: Discussionsupporting

confidence: 93%

“…There was no association between pDDIs and sex in our study. This was supported by similar findings in studies conducted in Egypt [ 16 ], and Pakistan [ 7 , 12 ]. In regard to the length of hospital study, there were inconsistencies in the results of previous pertinent research.…”

Section: Discussionsupporting

confidence: 88%

“…Minor severity pDDIs represented most of the detected interactions (51.66%) in only one previous study done in Morocco [ 15 ]. In studies conducted elsewhere, the majority of the observed pDDIs were of moderate severity [ 7 , 9 , 11 , 12 , 14 , 16 , 17 , 24 ]. Potential DDIs of a pharmacodynamic nature accounted for the majority of interactions, at 55.9%, which was in line with other studies conducted in India [ 9 , 13 ], UAE [ 17 ], and Serbia [ 14 ].…”

Section: Discussionmentioning

confidence: 99%

“…The previous four comorbidities were chosen in particular because they were the most prevalent among the patients in the cohort. The other variables were chosen as predictors because they were used in previous similar studies conducted in several countries [ 7 , 9 – 14 , 16 , 17 ].…”

Section: Methodsmentioning

confidence: 99%

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Potentially Harmful Drug–Drug Interactions and Their Associated Factors Among Hospitalized Cardiac Patients: A Cross-Sectional Study

Kalash,

Abdelrahman,

Al-Zakwani

et al. 2023

Drugs - Real World Outcomes

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Background Cardiovascular diseases are responsible for a significant proportion of mortalities worldwide. Elderly patients are the most affected by cardiovascular diseases, and because of factors such as polypharmacy, multimorbidity, and age-related changes in drug availability and metabolism, they are highly susceptible to the occurrence of drug–drug interactions. Drug–drug interactions are among the many drug-related problems leading to negative outcomes among inpatients and outpatients. Thus, it is important to investigate the prevalence, involved drugs, and factors related to potential drug–drug interactions (pDDIs) to properly optimize pharmacotherapy regimens for these patients. Objective We aimed to determine the prevalence of pDDIs, drugs most frequently implicated, and significant predictors associated with these interactions among hospitalized patients in the Cardiology Unit at Sultan Qaboos University Hospital in Muscat, Oman. Methods This retrospective cross-sectional study included 215 patients. Micromedex Drug-Reax ® was used to identify pDDIs. Data extracted from patients’ medical records were collected and analyzed. Univariable and multivariable linear regression was applied to determine the predictors associated with the observed pDDIs. Results A total of 2057 pDDIs were identified, with a median of nine (5–12) pDDIs per patient. Patients with at least one pDDI accounted for 97.2% of all the included patients. The majority of pDDIs were of major severity (52.6%), fair level of documentation (45.5%), and pharmacodynamic basis (55.9%). Potential drug–drug interactions between atorvastatin and clopidogrel were the most frequently observed (9%). Of all the detected pDDIs, around 79.6% of them included at least one antiplatelet drug. Having diabetes mellitus as a comorbidity ( B = 2.564, p < 0.001) and the number of drugs taken during the hospitalization period ( B = 0.562, p < 0.001) were factors positively associated with the frequency of pDDIs. Conclusions Potential drug–drug interactions were highly prevalent among hospitalized cardiac patients at Sultan Qaboos University Hospital, Muscat, Oman. Patients having diabetes as a comorbidity and with a high number of administered drugs were at a higher risk of an increased number of pDDIs.

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