Prevalence and risk factors of knee osteoarthritis in Huang-Pu District, Shanghai, China

Du, Hui; Chen, Shun‐le; Bao, Chunde; Wang, Xiaodong; Lu, Yu; Gu, Yue‐ying; Xu, Jianrong; Chai, Wei-Min; Chen, Jie; Nakamura, Hiroshi; Nishioka, Kusuki

doi:10.1007/s00296-004-0492-7

Cited by 75 publications

(56 citation statements)

References 15 publications

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“…Although the presence of an osteophyte or cyst, joint space narrowing, and subchondral sclerosis are all considered when determining the radiographic severity, the presence of definite osteophytes, the key feature of K/L Grade 2, is commonly used as the diagnostic criterion of knee OA [7,12,15,25,45]. Based on symptom severity our findings support the appropriateness of the K/L Grade 2 as reflecting clinically important OA.…”

Section: Discussionsupporting

confidence: 69%

“…The K/L scale is the scale most commonly used to evaluate the radiographic severity of knee OA [7,12,15,16,23,25,26,45]. Although the presence of an osteophyte or cyst, joint space narrowing, and subchondral sclerosis are all considered when determining the radiographic severity, the presence of definite osteophytes, the key feature of K/L Grade 2, is commonly used as the diagnostic criterion of knee OA [7,12,15,25,45].…”

Section: Discussionmentioning

confidence: 99%

“…In addition to the controversial association of clinical and radiographic severity, it is not known whether the symptoms of knee OA gradually worsen in correspondence with radiographic severity or whether they become substantially worse between certain radiographic grades. Although it is generally agreed knee OA can be diagnosed at Grade 2 on the K/L scale [7,12,15,25,45], it is unknown whether knees of K/L Grade 2 OA have more severe symptoms than those of K/L Grade 1.…”

mentioning

confidence: 99%

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Gender Differences in the Correlation between Symptom and Radiographic Severity in Patients with Knee Osteoarthritis

Cho

Chang

Yoo

et al. 2010

Clinical Orthopaedics &Amp; Related Research

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Background The effects of gender on the relationship between symptom manifestations and radiographic grades of knee osteoarthritis are not well understood. Questions/purposes We therefore determined the increments of symptom progression with regard to radiographic grades of knee osteoarthritis and asked if those increments differed by gender and whether symptom severity was differentially manifested by gender within the same grade. Methods We recruited 660 community residents; 368 (56%) women and 292 (44%) men. The mean subject age was 71.5 years (range, 65-91 years). Severity of symptoms was measured using the WOMAC and SF-36 scales, and the radiographic severity using Kellgren-Lawrence grades. Incremental changes in WOMAC and SF-36 scores were compared between adjacent Kellgren-Lawrence grades separately in men and women, and in the overall population. We compared symptom severity between men and women with the same radiographic grade. Results For the entire cohort, the mean incremental change in symptom severity was not gradual between the adjacent radiographic grades but was greater between Kellgren-Lawrence Grades 1 and 2 and Grades 2 and 3 than between Grades 0 and 1 or Grades 3 and 4. The patterns of incremental changes in symptom severity differed between men and women: women had more severe symptom progression between Kellgren-Lawrence Grades 2 and 3 and Grades 3 and 4 than men. Furthermore, women had worse mean WOMAC and SF-36 scores than men with the same radiographic grade of knee osteoarthritis. Conclusions These data suggest symptom progression is not gradual between adjacent radiographic grades, and for the same radiographic grade, symptoms are worse in women.

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Section: Discussionsupporting

confidence: 69%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Gender Differences in the Correlation between Symptom and Radiographic Severity in Patients with Knee Osteoarthritis

Cho

Chang

Yoo

et al. 2010

Clinical Orthopaedics &Amp; Related Research

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“…Women had a higher symptomatic OA prevalence than men (9.8% vs. 3.7%, P<0.01). The prevalence of symptomatic OA increased with age, from 1.3% in the 40-49-year-old group to 13.2% in the group aged 70 years and more (23). An exploratory study with a cross-sectional design performed in Poland with a randomly selected study population, including 404 (62.9%) rural women and 238 (37.1%) rural men (total 642), showed that 24.6% of the examined population suffered from joint degenerative disease, and OA was diagnosed in 14.7% of participants.…”

Section: Prevalencementioning

confidence: 99%

Osteoarthritis: etiology, epidemiology, impact on the individual and society and the main principles of management

Sakalauskienė

Jauniškienė²

2010

Medicina

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“…OA is the most common cause of limitation of activities of daily living after the middle aged. Knee OA, in particular, has a high prevalence in all over the world; recent studies in China show that the prevalence of radiographic knee OA increased according to age (Du et al 2005). The situation is similar in Japan, Korea, and elsewhere (Ikegawa et al 2003;Jin et al 2004).…”

Section: Introductionmentioning

confidence: 71%

Lack of association of single nucleotide polymorphism in LRCH1 with knee osteoarthritis susceptibility

et al. 2007

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A genetic association of knee osteoarthritis (OA) and a C/T transition single nucleotide polymorphism (SNP) (rs912428) located in intron 1 of the LRCH1 gene has recently been reported in European Caucasians; however, the results are inconsistent. Our objective was to evaluate the association in different knee OA populations. Three case-control association studies were conducted in Han Chinese, Japanese, and Greek Caucasian populations. The LRCH1 SNP was genotyped in patients who had primary symptomatic knee OA with radiographic confirmation and in matched controls, and the association was examined. We performed a meta-analysis for the studies together with results of two previous papers using the DerSimonian-Laird procedure and calculated the power of the pooled studies by the software R. A total of 1,145 OA patients and 1,266 controls were genotyped. No significant difference was detected in genotype or allele frequencies between knee OA and control groups in the three populations (all P [ 0.05). Association was not observed even after stratification by gender and Kellgren/Lawrence (K/L) scores. Meta-analysis also supported the lack of association between LRCH1 and knee OA. The strong heterogeneity between original and replication studies was detected in Caucasian populations. However, a tendency for the increase of TT genotype was observed in the European populations (OR = 1.46, P = 0.06). The powers for European and Asian replication studies were less than 0.8. Our results suggest that there is no association between LRCH1 and knee OA. However, lack of association should be concluded by further replication studies.

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Prevalence and risk factors of knee osteoarthritis in Huang-Pu District, Shanghai, China

Cited by 75 publications

References 15 publications

Gender Differences in the Correlation between Symptom and Radiographic Severity in Patients with Knee Osteoarthritis

Gender Differences in the Correlation between Symptom and Radiographic Severity in Patients with Knee Osteoarthritis

Osteoarthritis: etiology, epidemiology, impact on the individual and society and the main principles of management

Lack of association of single nucleotide polymorphism in LRCH1 with knee osteoarthritis susceptibility

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