Prevalence and risk factors for non‐alcoholic fatty liver disease among adults in an urban Sri Lankan population

Dassanayake, Anuradha S; Kasturiratne, A.; Rajindrajith, Shaman; Kalubowila, Udaya; Chakrawarthi, Sureka; Silva, Arjuna P. De; Makaya, Miyuki; Mizoue, Tetsuya; Kato, Norihiro; Wickremasinghe, Ananda R.; Silva, H. Janaka De

doi:10.1111/j.1440-1746.2009.05831.x

Cited by 174 publications

(157 citation statements)

References 39 publications

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“…Not unexpectedly, in rural India, a region characterized by traditional diets and lifestyles, the preva lence of NAFLD is low (~9%), whereas it mimics Western prevalence trends in urban populations, with rates vary ing between 16% and 32% [56][57][58] . A similar drama tic variation in NAFLD prevalence between urban and rural regions and along racial, economic and cultural bound aries (5-30%) was observed from smaller surveys in Sri Lanka, Malaysia, Singapore and Indonesia [59][60][61][62] . Overall, NAFLD prevalence varies but is increasing across Asia.…”

Section: Incidence Of Nafld and Future Projections In Europementioning

confidence: 53%

Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention

Younossi

Anstee

Marietti³

et al. 2017

Nat Rev Gastroenterol Hepatol

3,997

3,198

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Section: Incidence Of Nafld and Future Projections In Europementioning

confidence: 53%

Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention

Younossi

Anstee

Marietti³

et al. 2017

Nat Rev Gastroenterol Hepatol

3,997

3,198

View full text Add to dashboard Cite

“…48,49 This is in sharp contrast to Asian studies where the mean BMI is about 29 Kg/m 2 in India 53,54 ; 24 in Korea, 17 27 in Sri Lanka, 55 23 in China, 52 and 23 in Japan. 19 Initial studies from India that used the international criteria 56 for defining overweight and obesity found obesity in only 12-30% of patients 57,58 compared with 30-100% in Western studies depending on the population studied.…”

Section: Overweight/obesitycontrasting

confidence: 47%

Non-alcoholic Fatty Liver Disease: East Versus West

Agrawal

Duseja

2012

Journal of Clinical and Experimental Hepatology

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Non-alcoholic fatty liver disease (NAFLD) is an important cause of liver disease worldwide with prevalence ranging from 10% to 30% in various countries. It has become an important cause of unexplained rise in transaminases, cryptogenic cirrhosis, and cryptogenic hepatocellular carcinoma. Pathogenesis is related to obesity, insulin resistance, oxidative stress, lipotoxicity, and resultant inflammation in the liver progressing to fibrosis. Pharmacological treatment in patients with NAFLD is still evolving and the treatment of these patients rests upon lifestyle modification with diet and exercise being the cornerstones of therapy. While there are many similarities between patients with NAFLD from Asia and the West, there are certain features which make the patients with NAFLD from Asia stand apart. This review highlights the data on NAFLD from Asia comparing it with the data from the West. ( J CLIN EXP HEPATOL 2012;2:122-134)

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“…Association of higher meat intake and higher fat intake with NAFLD has been shown earlier too in a few studies. 18,19 Several studies have highlighted the fact that dietary intake rich in saturated fat and cholesterol and sweet carbohydrates was associated with NAFLD. 20,21 Fast food and soft drinks contain artificial sweeteners, such as fructose.…”

Section: Singh Et Al Risk Factors Associated With Non-alcoholic Fattymentioning

confidence: 99%

Risk Factors Associated With Non-Alcoholic Fatty Liver Disease in Indians: A Case–Control Study

Singh

Misra

et al. 2015

Journal of Clinical and Experimental Hepatology

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Background/Aims: NAFLD has today emerged as the leading cause of liver disorder. There is scanty data on risk factors associated with NAFLD emanating from India. The present study was conducted to identify the risk factors associated with NAFLD. Methods: 464 consecutive NAFLD patients and 181 control patients were subjected to detailed questionnaire regarding their lifestyle and dietary risk factors. Anthropometric measurements were obtained and biochemical assays were done. Comparison of different variables was made between NAFLD patients and controls using principal component analysis (PCA). Results: NAFLD patients had higher BMI [26.25 AE 3.80 vs 21.46 AE 3.08 kg/m 2 , P = 0.000], waist-hip ratio [0.96 AE 0.12 vs 0.90 AE 0.08, P = 0.000] and waist-height ratio [0.57 AE 0.09 vs 0.50 AE 0.06, P = 0.000] compared to controls. Fasting blood sugar [101.88 AE 31.57 vs 90.87 AE 10.74 mg/dl] and triglyceride levels [196.16 AE 102.66 vs 133.20 AE 58.37 mg/dl] were significantly higher in NAFLD group. HOMA-IR was also higher in NAFLD group [2.53 AE 2.57 vs 1.16 AE 0.58, P = 0.000]. Majority (90.2%) of NAFLD patients were sedentary. Family history of metabolic syndrome (MS) was positively correlated with NAFLD. Dietary risk factors associated with NAFLD were non-vegetarian diet [35% vs 23%, P = 0.002], fried food [35% vs 9%, P = 0.000], spicy foods [51% vs 15%, P = 0.001] and tea [55% vs 39%, P = 0.001]. Diabetes, hypertension, snoring and sleep apnoea syndrome were common factors in NAFLD. On multivariate PCA, waist/height ratio and BMI were significantly higher in the NAFLD patients. Conclusion: The risk factors associated with NAFLD are sedentary lifestyle, obesity family history of MS, consumption of meat/fish, spicy foods, fried foods and tea. Other risk factors associated with NAFLD included snoring and MS. ( J CLIN EXP HEPATOL 2015;5:295-302) N on-alcoholic fatty liver disease (NAFLD) is a distinct clinico-pathologic entity characterized histologically by a spectrum ranging from simple steatosis to steatohepatitis (NASH), cirrhosis and even hepatocellular carcinoma (HCC). 1,2 NAFLD (steatosis of the liver) is highly prevalent in Western countries. 1 With the introduction of westernized lifestyle and the increasing frequency of obesity in the Asia-Pacific region, the prevalence of NAFLD has increased over the past two decades.Studies from different regions of India have shown that NAFLD is very common in Indians. [3][4][5] Risk factors implicated in the development of NAFLD are obesity and metabolic syndrome (MS). 6,7 However, it is obvious that NAFLD is multifactorial and identifying the various risk factors associated with NAFLD in our population could help us to intervene in order to prevent its progression to more severe forms of the disease.The few studies identifying the risk factors associated with NAFLD have emanated from the West, where the profiles of NAFLD patients appear to be different. [8][9][10] The observed differences in Indian NAFLD patients include a lower frequency of MS, 9,11 lesser degree ...

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Prevalence and risk factors for non‐alcoholic fatty liver disease among adults in an urban Sri Lankan population

Abstract: The prevalence of NAFLD among adults in this urban Sri Lankan community is high and is strongly associated with constituent features of the metabolic syndrome.

Cited by 174 publications

References 39 publications

Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention

Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention

Non-alcoholic Fatty Liver Disease: East Versus West

Risk Factors Associated With Non-Alcoholic Fatty Liver Disease in Indians: A Case–Control Study

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