Prevalence and risk factors for vitamin D insufficiency and deficiency at birth and associated outcome

Marshall, Ian; Mehta, Rajeev; Ayers, Charletta; Dhumal, Smita; Petrová, Anna

doi:10.1186/s12887-016-0741-4

Cited by 25 publications

(21 citation statements)

References 34 publications

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“…The prevalence of 25OHD deficiency (<20 ng/ml) was lower than that reported in infant cord blood in the United States [24] and in a recent French study [25], which showed about two thirds of newborns with 25OHD level <20 ng/ml. This discrepancy may be due to the population selection at inclusion, which thus differed from the targeted population [17] and the follow-up as described, with older mothers, having higher incomes and education and higher 25OHD levels in included than excluded children.…”

Section: We Report Generally Low Serum 25ohd Level At Birth In This Scontrasting

confidence: 60%

Cord-blood vitamin D level and night sleep duration in preschoolers in the EDEN mother-child birth cohort

et al. 2019

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Phone: + 33 1 45 59 51 09. Ethical approval and consent to participate:The study was approved by the ethics research committee of Bicêtre Hospital (Comité Consultatif de Protection des Personnes dans la Recherche Biomédicale) and by the Data Protection Authority (Commission Nationale de l'Informatique et des Libertés). ABSTRACTObjective: 25-hydroxyvitamin D (25OHD) deficiency has been associated with sleep disorders in adults. Only three cross-sectional studies were performed in children and showed an association between 25OHD deficiency and both obstructive sleep apnea syndrome and primary snoring. No longitudinal study has been performed in children from the general population. We analyzed the association between cord-blood vitamin D level at birth and night-sleep duration trajectories for children between 2 and 5-6 years old in a non-clinical cohort. Method:We included 264 children from the French EDEN mother-child birth-cohort with both cord-blood 25OHD level determined by radio-immunoassay at birth, and night-sleep trajectories for children between 2 and 5-6 years old obtained by the group-based trajectory modeling method. Associations between 25OHD and sleep trajectories were assessed by multinomial logistic regression adjusted for maternal and child characteristics. Results:The trajectories short sleep (<10h30/night), medium-low sleep (10h30-11h00/night), medium-high sleep (≈11h30/night), long sleep (≥11h30/night) and changing sleep (decreased from ≥11h30 to 10h30-11h00/night) represented 5%, 46%, 37%, 4% and 8% of the children, respectively. The mean 25OHD level was 19 ng/ml (SD=11, range 3 to 63). It was 12 (SD=7), 20 (SD=11), 19 (SD=10), 14 (SD=7) and 16 (SD=8) ng/ml for children with short, mediumlow, medium-high, long and changing sleep trajectories, respectively. On adjusted analysis, for each 1-ng/ml decrease in 25OHD level, the odds of belonging to the short sleep versus medium-high sleep trajectory was increased (odds ratio =1.12, 95% confidence interval [1.01-1.25]). We found no other significant association between 25OHD level and other trajectories. Conclusion:Low 25OHD level at birth may be associated with increased probability of being a persistent short sleeper in preschool years. These results need confirmation.

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Section: We Report Generally Low Serum 25ohd Level At Birth In This Scontrasting

confidence: 60%

Cord-blood vitamin D level and night sleep duration in preschoolers in the EDEN mother-child birth cohort

et al. 2019

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“…Similar finding was reported in a study done by Marshall et al, who stated that younger maternal age was associated with cord blood vitamin D deficiency or insufficiency. 8 13 mothers were primiparous and 17 were multiparous. The mean vitamin D levels in the primiparous mothers was 13.68±3.5 ng/ml and in the multiparous mothers was 16.27±4.19 ng/ml.…”

Section: Discussionmentioning

confidence: 99%

A study on vitamin D levels in preterm and term neonates and their mothers

Thomas

Khan

Paul

et al. 2020

Int J Contemp Pediatr

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Background: Vitamin D is a fat-soluble vitamin which has immunomodulatory and anti-inflammatory effects. Vitamin D deficiency is a worldwide problem and yet is one of the most under diagnosed and under treated nutritional deficiency. Despite India being in the tropical zone with plentiful sunlight, there is a wide prevalence of vitamin D deficiency.Methods: Cross sectional descriptive study done in a tertiary care hospital involving 30 mother baby dyads equally divided into term and preterm babies. Maternal vitamin D levels (before delivery) and cord blood vitamin D levels (after delivery) were estimated.Results: All the mothers had low vitamin D levels, 93% having deficiency and 7% having insufficiency. The maternal vitamin D levels correlated with cord blood vitamin D levels. There was significant correlation between maternal vitamin D levels and cord blood vitamin D levels with maternal age and parity. There was no correlation between maternal vitamin D levels with gestational age, sociodemographic profile or neonatal anthropometry.Conclusions: Vitamin D deficiency is widely prevalent even in well-nourished mothers. Vitamin D supplementation may be helpful in antenatal mothers. Larger studies are needed to study the prevalence of vitamin D deficiency in mothers and babies and look for effectiveness of supplementation.

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“…The U.S. data (NHANES 2003–2006) showed that 11% of women of childbearing age were deficient in vitamin D, while another 26% were insufficient [Zhao, Ford, Tsai, Li, & Croft, ], using a conservative definition (<12 and 12 to <20 ng/mL, respectively, which combined are defined as deficient in other studies, equivalent to 50 nmol/L). Higher rates of deficiency have been reported in other studies including of pregnant women [Hamilton et al, ; Kiely, Hemmingway, & O'Callaghan, ; Marshall, Mehta, Ayers, Dhumal, & Petrova, ]. “Vitamin D” refers to a group of steroid molecules, with formation of vitamin D 3 , the major circulating form, in the body dependent on sunlight (UVB) exposure.…”

Section: Introductionmentioning

confidence: 97%

“…There is increasing evidence of associations of vitamin D deficiency with a wide range of maternal and child health conditions in addition to the well‐known effect on calcium metabolism and bone mineralization [Basit, ; Dror et al, ; Holick, ; Marshall et al, ]. Vitamin D has been shown to play a role in brain development, leading to the suggestion of a possible association with ASD a decade ago [Cannell, ].…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, vitamin D plays a well‐documented role in mediating immune function [Cantorna, Zhu, Froicu, & Wittke, ; Hayes, Nashold, Spach, & Pedersen, ; Hewison, ]. Maternal vitamin D levels during pregnancy are of particular concern because fetal and neonatal vitamin D status depends on them, with neonatal levels typically measured in cord blood at 60%–80% of maternal levels [Hollis, Johnson, Hulsey, Ebeling, & Wagner, ; Kiely et al, ; Marshall et al, ]. Yet the optimal level of vitamin D to prevent adverse pregnancy outcomes is not clear and separate standards of intake for pregnant women are not established, although there is movement towards supplementation of pregnant women [ACOG Committee on Obstetric Practice, ; Hollis et al, ; Urrutia & Thorp, ].…”

Section: Introductionmentioning

confidence: 99%

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Newborn vitamin D levels in relation to autism spectrum disorders and intellectual disability: A case–control study in california

et al. 2019

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Vitamin D deficiency has been increasing concurrently with prevalence of autism spectrum disorders (ASD), and emerging evidence suggests vitamin D is involved in brain development. Most prior studies of ASD examined vitamin D levels in children already diagnosed, but a few examined levels during perinatal development, the more likely susceptibility period. Therefore, we examined newborn vitamin D levels in a case-control study conducted among births in 2000-2003 in southern California. Children with ASD (N = 563) or intellectual disability (ID) (N = 190) were identified from the Department of Developmental Services and compared to population controls (N = 436) identified from birth certificates. 25-hydroxyvitamin D (25(OH)D) was measured in archived newborn dried blood spots by a sensitive assay and corrected to sera equivalents. We categorized 25(OH) D levels as deficient (<50 nmol/L), insufficient (50-74 nmol/L), and sufficient (≥75 nmol/L), and also examined continuous levels, using logistic regression. The adjusted odds ratios (AOR) and 95% confidence intervals for ASD were 0.96 (0.64-1.4) for 25(OH)D deficiency (14% of newborns) and 1.2 (0.86-1.6) for insufficiency (26% of newborns). The AORs for continuous 25(OH)D (per 25 nmol/L) were 1.0 (0.91-1.09) for ASD and 1.14 (1.0-1.30) for ID. Thus, in this relatively large study of measured newborn vitamin D levels, our results do not support the hypothesis of lower 25(OH)D being associated with higher risk of ASD (or ID), although we observed suggestion of interactions with sex and race/ethnicity. 25(OH)D levels were relatively high (median 84 nmol/L in controls), so results may differ in populations with higher prevalence of low vitamin D levels. Autism Res 2019, 12: 989-998.Lay Summary: We studied whether vitamin D levels measured at birth were related to whether a child later developed autism (or low IQ). Our results did not show that children with autism, or low IQ, overall had lower vitamin D levels at birth than children without autism. Vitamin D levels were fairly high, on average, in these children born in Southern California.

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Prevalence and risk factors for vitamin D insufficiency and deficiency at birth and associated outcome

Cited by 25 publications

References 34 publications

Cord-blood vitamin D level and night sleep duration in preschoolers in the EDEN mother-child birth cohort

Cord-blood vitamin D level and night sleep duration in preschoolers in the EDEN mother-child birth cohort

A study on vitamin D levels in preterm and term neonates and their mothers

Newborn vitamin D levels in relation to autism spectrum disorders and intellectual disability: A case–control study in california

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