Prevalence and Risk Factors for Early Seizure in Patients with Traumatic Brain Injury: Analysis from National Trauma Data Bank

Majidi, Shahram; Makke, Yamane; Ewida, Amr; Sianati, Bahareh; Qureshi, Adnan I.; Koubeissi, Mohamad Z.

doi:10.1007/s12028-016-0363-6

Cited by 35 publications

(65 citation statements)

References 26 publications

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“…5 Several studies have identified risk factors for occurrence of acute symptomatic seizure (ASz), such as older age, alcoholism, art of trauma, depressed skull fracture, dura penetration, penetration injuries and cortical injuries. [6][7][8][9][10][11][12] Previously, we were able to show a strong correlation between occurrence of seizures and aSDH, which was well in line with previous studies, whereas opinions regarding seizures and cSDH are contradictory. [6][7][8][9][10][11][12] Previously, we were able to show a strong correlation between occurrence of seizures and aSDH, which was well in line with previous studies, whereas opinions regarding seizures and cSDH are contradictory.…”

Section: Introductionsupporting

confidence: 91%

“…In particular, acute (aSDH) and chronic subdural hematoma (cSDH) have been shown to be one of the major predictors for ASz and a high cumulative probability of 27.8% for late seizures occurring within 2 years. [6][7][8][9][10][11][12] Previously, we were able to show a strong correlation between occurrence of seizures and aSDH, which was well in line with previous studies, whereas opinions regarding seizures and cSDH are contradictory. 11,13,14 The reported incidence of seizures in cSDH varies in between 2% and 42%, and some predictors, such as alcoholism, male sex, low Glasgow Coma Scale (GCS) at admission, previous stroke, and hematoma density, were identified in a smaller number of patients.…”

Section: Introductionsupporting

confidence: 91%

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Seizure and status epilepticus in chronic subdural hematoma

et al. 2019

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Background: Acute symptomatic seizure (ASz) and status epilepticus (SE) are serious conditions associated with poor quality of life, with unfavorable psychosocial and functional outcome. Chronic subdural hematoma (cSDH) is a common neurosurgical disease related to those complications; therefore, we aimed to evaluate incidence, predictors of ASz/SE, and outcome in this cohort. Methods:We retrospectively analyzed patient diagnosed cSDH between 2010 and 2017. Beside their incidence of ASz/SE, patient characteristics, symptoms at admission, comorbidities, and all previously published relevant parameters were assessed.Recurrence rate and functional outcome were analyzed at hospital discharge and 90-day follow-up.Results: A total of 375 patients were included; incidence of ASz was 15.2% and of SE, 1.9%. In the univariate analysis, drainage insertion (P = 0.004; OR = 0.3) was a significant negative predictor for ASz/SE and multivariate analysis, including all significant parameters, designated GCS ≤13 at admission (P = 0.09; OR = 1.9), remote stroke (P = 0.009; OR = 2.9), and recurrence rate within 14 days (P = 0.001; OR = 3.3;with an incidence of 13%) as independent predictors for ASz/SE. Overall, patients with ASz/SE had significantly unfavorable outcome at discharge (54.7%; P < 0.001) and follow-up (39.5%; P < 0.001) with only slight improvement. Late seizures occurred in 3.8% within follow-up period. Any patient with SE had an unfavorable outcome at discharge without any improvement at follow-up having a mortality rate of 14.2%.Conclusion: Independent predictors for ASz/SE are GCS ≤13 at admission, remote stroke, and recurrent hematoma in patients with cSDH, which is associated with worse functional outcome, particularly those with SE. Due to the higher rate of seizures than recurrence rate, a routine pre-and postoperative EEG besides CT is recommended. K E Y W O R D Schronic subdural hematoma, EEG, functional outcome, predictors, seizures, status epilepticus | 195 WON et al.

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Section: Introductionsupporting

confidence: 91%

Section: Introductionsupporting

confidence: 91%

Seizure and status epilepticus in chronic subdural hematoma

et al. 2019

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“…Большинство опубликованных ранее исследований, посвященных ПТП и эпилепсии, проводились на постгоспитальном этапе или с анализом ретроспективных данных [15,17,19,27,28]. В настоящей работе был осуществлен проспективный анализ ПТП, возникших в острый период ЧМТ и в течение 2 следующих лет.…”

Section: Discussionunclassified

“…По данным литературы [13][14][15][16][17][18][19][20][21][22][23], заболеваемость ранними и поздними ПТП составляет от 2 до 19% и при определенных условиях может достигать 30% и более. Доля пациентов с ранними (18,1%) и поздними (6,3%) приступами у обследуемых пациентов в настоящем исследовании находилась в пределах указанных диапазонов.…”

Section: Discussionunclassified

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Posttraumatic seizures: a prospective cohort study

Krylov¹,

Teplyshova²,

Mutaeva³

et al. 2018

Z. nevrol. psikhiatr. im. S.S. Korsakova

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Черепно-мозговая травма (ЧМТ) имеет большое социально-экономическое значение, так как преимущественно затрагивает людей трудоспособного возраста и ведет к снижению качества жизни, является частой причиной инвалидности и смертности пострадавших [1-5]. По данным Всемирной организации здравоохранения (ВОЗ), частота возникновения ЧМТ составляет 600 случаев на 100 000 в год [6].

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Risk Factors and Prognosis of Early Posttraumatic Seizures in Moderate to Severe Traumatic Brain Injury

et al. 2022

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IMPORTANCEEarly posttraumatic seizures (EPS) that may occur following a traumatic brain injury (TBI) are associated with poorer outcomes and development of posttraumatic epilepsy (PTE).OBJECTIVE To evaluate risk factors for EPS, associated morbidity and mortality, and contribution to PTE.DESIGN, SETTING, AND PARTICIPANTS Data were collected from an Australian registry-based cohort study of adults (age Ն18 years) with moderate to severe TBI from January 2005 to December 2019, with 2-year follow-up. The statewide trauma registry, conducted on an opt-out basis in Victoria (population 6.5 million), had 15 152 patients with moderate to severe TBI identified via Abbreviated Injury Scale (AIS) head severity score, with an opt-out rate less than 0.5% (opt-out n = 136).MAIN OUTCOMES AND MEASURES EPS were identified via International Statistical Classification of Diseases, Tenth Revision, Australian Modification (ICD-10-AM) codes recorded after the acute admission. Outcome measures also included in-hospital metrics, 2-year outcomes including PTE, and post-discharge mortality. Adaptive least absolute shrinkage and selection operator (LASSO) regression was used to build a prediction model for risk factors of EPS. RESULTS Among the 15 152 participants (10 457 [69%] male; median [IQR] age, 60 [35-79] y), 416 (2.7%) were identified with EPS, including 27 (0.2%) with status epilepticus. Significant risk factors on multivariable analysis for developing EPS were younger age, higher Charlson Comorbidity Index, TBI sustained from a low fall, subdural hemorrhage, subarachnoid hemorrhage, higher Injury Severity Score, and greater head injury severity, measured using the AIS and Glasgow Coma Score. After adjustment for confounders, EPS were associated with increased ICU admission and ICU length of stay, ventilation and duration, hospital length of stay, and discharge to inpatient rehabilitation rather than home, but not in-hospital mortality. Outcomes in TBI admission survivors at 24 months, including mortality (relative risk [RR] = 2.14; 95% CI, 1.32-3.46; P = .002), development of PTE (RR = 2.91; 95% CI, 2.22-3.81; P < .001), and use of antiseizure medications (RR = 2.44; 95% CI, 1.98-3.02; P < .001), were poorer for cases with EPS after adjustment for confounders. The prediction model for EPS had an area under the receiver operating characteristic curve of 0.72 (95% CI, 0.66-0.79), sensitivity of 66%, and specificity of 73% in the validation set.DISCUSSION We identified important risk factors for EPS following moderate to severe TBI. Early posttraumatic seizures were associated with longer ICU and hospital admissions, ICU ventilation, and poorer 24-month outcomes including mortality and development of PTE.

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Prevalence and Risk Factors for Early Seizure in Patients with Traumatic Brain Injury: Analysis from National Trauma Data Bank

Abstract: In-hospital seizures occur in 0.4% of all TBI patients. Although infrequent, seizure occurrence is associated with higher rates of hospital complications such as pneumonia and ARDS and is an independent predictor of longer hospital stay and worse hospital outcome.

Cited by 35 publications

References 26 publications

Seizure and status epilepticus in chronic subdural hematoma

Seizure and status epilepticus in chronic subdural hematoma

Posttraumatic seizures: a prospective cohort study

Risk Factors and Prognosis of Early Posttraumatic Seizures in Moderate to Severe Traumatic Brain Injury

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