Prevalence and risk factors for chronic kidney disease among <scp>HIV</scp>‐infected antiretroviral therapy‐naïve patients in <scp>M</scp>ainland <scp>C</scp>hina: A multicenter cross‐sectional study

Cao, Ying; Gong, Mengchun; Han, Yang; Xie, Jing; Li, Xuemei; Zhang, Lixia; Li, Yanling; Song, Xiaojing; Zhu, Ting; Li, Taisheng

doi:10.1111/nep.12031

Cited by 28 publications

(28 citation statements)

References 26 publications

(44 reference statements)

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“…A summary table with the results of study selection including the list of enrolled and excluded papers are reported in Additional file 2, 3, and 4. We identified 19 studies (146,151 unique patients with HIV) [Szczech et al, ; Tedaldi et al, ; Szczech et al, ; Ando et al, ; Di Biagio et al, 2011; Flandre et al, ; George et al, ; Yanagisawa et al, ; Peters et al, ; Jotwani et al, ; Kalayjian et al, ; Mocroft et al, ; Bickel et al, ; Cao et al, ; Estrella et al, ; Lucas et al, ; Reynes et al, ; Banerjee et al, ; Hsieh et al, ]. Among longitudinal studies (n = 10), eight evaluated the incidence of CKD, and two the incidence of proteinuria.…”

Section: Resultsmentioning

confidence: 99%

“…Five cohort studies (n = 13,853 unique patients), four having cross‐sectional design addressed the prevalence of CKD in adults with HIV‐HCV co‐infection [Di Biagio et al, 2011; Mocroft et al, ; Bickel et al, ; Cao et al, ; Hsieh et al, ] (Table ). The relationship between HCV‐HIV co‐infection and increased frequency of lowered GFR did not reach statistical significance, adjusted OR, 1.58 (95%CI, 0.81; 2.34, NS).…”

Section: Resultsmentioning

confidence: 99%

“…Cao et al . []: HR adjusted for age, race, plasma HIV viral load, HBV, CD4 cell count, BMI, diabetes mellitus, hypertension. Hsieh et al .…”

Section: Resultsmentioning

confidence: 99%

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Hepatitis C virus increases the risk of kidney disease among HIV‐positive patients: Systematic review and meta‐analysis

Fabrizi

Dixit

Martin

2015

Journal of Medical Virology

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Kidney disease has become an important co-morbidity among human immunodeficiency virus-infected patients as they live longer in the era of highly effective antiretroviral therapy. It remains unclear how co-infection with hepatitis C virus impacts on the trajectory of kidney disease among HIV-infected patients. To evaluate the effect of co-infection with HCV on the risk of kidney disease in HIV-infected populations. We conducted a systematic review of the published medical literature to determine if hepatitis C co-infection is associated with increased likelihood of chronic kidney disease in HIV-positive adults. We used the random effects model of DerSimonian and Laird to generate a summary estimate of the relative risk for chronic kidney disease (defined by reduced glomerular filtration rate and/or detectable proteinuria) with hepatitis C virus across the published studies. Meta-regression and stratified analysis were also conducted. We identified 19 studies (146,151 unique patients with HIV) and separate meta-analyses were performed according to the outcome. Aggregation of longitudinal studies (n = 8, 105,462 unique patients) showed a relationship between HCV infection and increased risk of reduced glomerular filtration rate among HIV-infected individuals, the summary estimate for adjusted hazard ratio was 1.64 (95%CI, 1.28; 2.0, P < 0.001) in HIV-HCV co-infected individuals compared with those having HIV mono-infection. No between-studies heterogeneity was noted (P-value by Q test = 0.08). HCV positive serology was an independent risk factor for proteinuria; adjusted effect estimate, 1.23 (95% confidence interval, 1.18; 1.28, P = 0.001) (n = 6 studies; 26,835 unique patients). In meta-regression, we noted the impact of ageing (P = 0.0001) upon the adjusted hazard ratio of incidence of reduced glomerular filtration rate among HCV-HIV co-infected patients; a negative association between frequency of males (P = 0.001) and the adjusted hazard ratio of prevalence of low glomerular filtration rate was found. Hepatitis C co-infection is associated with a significant increase in the risk of reduced glomerular filtration rate and/or detectable proteinuria among HIV-infected individuals.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Hepatitis C virus increases the risk of kidney disease among HIV‐positive patients: Systematic review and meta‐analysis

Fabrizi

Dixit

Martin

2015

Journal of Medical Virology

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“…In this context, beyond ART, comprehensive multi-system screening and management has been recognized as an increasingly important component of HIV care. On the one hand, HIV infection and its associated immune activation has been identified as an independent risk factor for many non-AIDS complications, including atherosclerosis, cardiovascular diseases, osteoporosis, and renal diseases [19][20][21][22][23][24]. On the other hand, lifelong use of ART also exerts systemic influences including but not limited to alterations in lipid and glucose metabolism, liver and renal functions, bone and mineral homeostasis, and neuropsychiatric changes.…”

Section: Promoting Multidisciplinary Care and Integrating The Hiv/aidmentioning

confidence: 99%

Optimizing Treatment for Adults with HIV/AIDS in China: Successes over Two Decades and Remaining Challenges

Cao

Hsieh

2020

Curr HIV/AIDS Rep

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Purpose of Review The introduction of the National Free Antiretroviral Therapy Program (NFATP) in 2003 by the China National Center for AIDS/STD Control and Prevention has led to dramatic increases in antiretroviral therapy (ART) coverage among HIV-infected Chinese patients. Despite limitations in the number of available free antiretroviral drugs, the overall mortality associated with HIV/AIDS has dropped from 39.3 per 100 person-years in 2002 to 3.1 in 2014. In this review, we summarize the challenges, responses, and achievements of antiretroviral therapy (ART) in China over the past 20 years. Recent Findings Continuous optimization of the Chinese National Guidelines for HIV/AIDS Diagnosis and Treatment has been guided by data from serial domestic multi-center studies aimed at evaluating efficacy and toxicity of available ART regimens among Chinese patients with HIV, with the goal of maximizing adherence, access, and efficacy. In addition, increasing attention has been focused on the importance of continuity in the HIV care cascade to promote linkage to care, and address the multidisciplinary chronic care needs HIV/AIDS patients on lifelong ART. Summary Great progress has been achieved in the past 20 years in terms of access to and optimization of antiretroviral treatment in China. As the number of patients receiving long-term ART continues to grow, the focus of HIV/AIDS treatment has gradually transitioned from urgent care to the management of non-AIDS-related chronic complications and control of chronic inflammation.

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“…This trend is limited to the African population. In China, in the work of Cao et al [15], we note a male predominance with a sex ratio of 2.87. This difference in sex can be explained either by the fact that women consult late because of their cultural weight, or because they are more affected by HIV or by the influence of female hormones such as estrogen.…”

Section: Discussionmentioning

confidence: 66%

Epidemiological, Clinical and Biological Aspects of Kidney Disease in People Living with HIV Naive Antiretroviral Therapy at CHU Sylvanus Olympio of Lome (TOGO)

Sabi¹,

Dolaama²,

Amekoudi³

et al. 2019

OJNeph

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Prevalence and risk factors for chronic kidney disease among HIV‐infected antiretroviral therapy‐naïve patients in Mainland China: A multicenter cross‐sectional study

Abstract: The incidence of CKD is high in Chinese HIV-infected ART-naïve patients. Traditional risk factors for renal disease, such as advancing age, HCV co-infection, and higher plasma viral load were correlated with CKD in the present patient samples.

Cited by 28 publications

References 26 publications

Hepatitis C virus increases the risk of kidney disease among HIV‐positive patients: Systematic review and meta‐analysis

Hepatitis C virus increases the risk of kidney disease among HIV‐positive patients: Systematic review and meta‐analysis

Optimizing Treatment for Adults with HIV/AIDS in China: Successes over Two Decades and Remaining Challenges

Epidemiological, Clinical and Biological Aspects of Kidney Disease in People Living with HIV Naive Antiretroviral Therapy at CHU Sylvanus Olympio of Lome (TOGO)

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