Prevalence and Risk Factors for Cataract in Diabetes: Sankara Nethralaya Diabetic Retinopathy Epidemiology and Molecular Genetics Study, Report No. 17

Raman, Rajiv; Pal, Swakshyar Saumya; Adams, James Subrat Kumar; Rani, Padmaja Kumari; Kulothungan, Vaitheeswaran; Sharma, Tarun

doi:10.1167/iovs.10-5414

Cited by 57 publications

(47 citation statements)

References 39 publications

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“…In the Korean diabetic population, the age- and gender-adjusted prevalence of nuclear cataracts (16.0%) was higher than that of cortical cataracts (5.6%), with posterior subcapsular cataracts (1.8%) being the least common type. This relative distribution of cataracts in the diabetic population appears to be consistent with that reported in Kinmen, Taiwan, in which nuclear cataracts were most common, followed by cortical cataracts [21], but is dissimilar to an Indian study [23]. In that study, even though the percentage of posterior subcapsular cataracts (1.1%) was comparable with that in the present study, in contrast, the prevalence of cortical cataracts (15.1%) was higher than that of nuclear cataracts (5.0%).…”

Section: Discussionsupporting

confidence: 88%

“…Although prevalence of cataract in the present study seems to be higher than among the US population, young and middle aged patients with diabetes might be at greatest risk of cataract in both Korean and US populations. When considering the definition of cataracts using the LOCS III, the overall rate of cataracts in the diabetic population in the present study appeared to be similar to those documented in Asian populations, including Chinese, Singaporeans, and Indians [21]–[23].…”

Section: Discussionsupporting

confidence: 81%

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Prevalence of and Factors Associated with Lens Opacities in a Korean Adult Population with and without Diabetes: The 2008–2009 Korea National Health and Nutrition Examination Survey

Kim

Lee

et al. 2014

PLoS ONE

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ObjectiveWe examined the prevalence of and factors associated with lens opacities in a Korean adult population with and without diabetes.Research Design and MethodsAmong the 11,163 adults (≥19 years old) from the fourth Korea National Health and Nutrition Examination Survey in 2008–2009, the data from laboratory tests, nutritional surveys, and slit-lamp examinations of 10,248 persons (4,397 men, 5,851 women) were examined. Cataract was defined as the presence of any nuclear, cortical, subcapsular, or mixed cataract in at least one eye, using the Lens Opacities Classification System III.ResultsThe weighted prevalence of cataracts were 23.5% [95% confidence interval (CI), 21.7–25.4] in a Korean adult population (19–39 years old, 1.8% [1.3–2.5], 40–64 years old, 25.2% [22.5–28.1],≥65 years old, 87.8% [85.4–89.9])and 54.7% [50.1–59.2] in a diabetic population(19–39 years old, 11.6% [4.5–26.5], 40–64 years old, 41.1% [35.4–47.0], ≥65 years old, 88.3% [83.5–91.8]). In a logistic regression analysis, age, myopia, and the presence of diabetes were independent risk factors. For young (age 19–39 years) and middle aged (age 40–65 years) adults with diabetes, the OR of having a lens opacity is 5.04 [1.41–17.98] and 1.47 [1.11–1.94], respectively, as those without diabetes, whereas for adults aged 65 and older, there was no difference in the prevalence of cataract.ConclusionsAccording to these national survey data, ∼ 24% of Korean adults and ∼ 55% of people with diabetes have cataracts. The presence of diabetes was independently associated with cataracts in young and middle aged adults.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionsupporting

confidence: 81%

Prevalence of and Factors Associated with Lens Opacities in a Korean Adult Population with and without Diabetes: The 2008–2009 Korea National Health and Nutrition Examination Survey

Kim

Lee

et al. 2014

PLoS ONE

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“…These results must be treated with caution. Prevalence of cataracts is known to be strongly related to the duration of diabetes and parameters reflecting poor diabetes management, such as high levels of HbA1c, fasting blood sugar or macroalbuminuria [73], [74]. This poor control of diabetes, which could also be related to other metabolic syndrome complications, would lead the individual to a poorer health status and higher degree of disability compared with the expected addition of the individual effects of diabetes and cataracts.…”

Section: Discussionmentioning

confidence: 99%

Impact of Multimorbidity on Disability and Quality of Life in the Spanish Older Population

et al. 2014

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BackgroundPopulation aging is closely related to high prevalence of chronic conditions in developed countries. In this context, health care policies aim to increase life span cost-effectively while maintaining quality of life and functional ability. There is still, however, a need for further understanding of how chronic conditions affect these health aspects. The aim of this paper is to assess the individual and combined impact of chronic physical and mental conditions on quality of life and disability in Spain, and secondly to show gender trends.MethodsCross-sectional data were collected from the COURAGE study. A total of 3,625 participants over 50 years old from Spain were included. Crude and adjusted multiple linear regressions were conducted to detect associations between individual chronic conditions and disability, and between chronic conditions and quality of life. Separate models were used to assess the influence of the number of diseases on the same variables. Additional analogous regressions were performed for males and females.ResultsAll chronic conditions except hypertension were statistically associated with poor results in quality of life and disability. Depression, anxiety and stroke were found to have the greatest impact on outcomes. The number of chronic conditions was associated with substantially lower quality of life [β for 4+ diseases: −18.10 (−20.95,−15.25)] and greater disability [β for 4+ diseases: 27.64 (24.99,30.29]. In general, women suffered from higher rates of multimorbidity and poorer results in quality of life and disability.ConclusionsChronic conditions impact greatly on quality of life and disability in the older Spanish population, especially when co-occurring diseases are added. Multimorbidity considerations should be a priority in the development of future health policies focused on quality of life and disability. Further studies would benefit from an expanded selection of diseases. Policies should also deal with gender idiosyncrasy in certain cases.

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“…The Beaver Dam Eye Study (BDES), Blue Mountains Eye Study (BMES), and Visual Impairment Project have documented an association between diabetes and incidence of posterior subcapsular cataract (PSC) and, to a lesser extent, incidence of cortical cataract (CC). [3][4][5][6][7][8][9][10][11][12][13] In our previously reported population-based cross-sectional study, 14 higher age, macroalbuminuria, and higher glycated hemoglobin were reported as risk factors for the prevalence of any cataract. We observed that higher serum triglycerides are associated with nuclear cataract, whereas female sex and poor glycemic control are associated with PSC and nuclear cataract, respectively.…”

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confidence: 84%

Incidence, Progression, and Risk Factors for Cataract in Type 2 Diabetes

Srinivasan¹,

Raman²,

Swaminathan³

et al. 2017

Invest. Ophthalmol. Vis. Sci.

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PURPOSE.We report the 4-year incidence, progression, and risk factors of cataract subtypes in type 2 diabetes. METHODS.A total of 779 subjects completed baseline and 4-year follow-up.RESULTS. The incidences of nuclear opalescence (NO), nuclear color (NC), cortical cataract (CC), and posterior subcapsular cataract (PSC) were 70%, 55.2%, 25.7%, and 7.3%, respectively. One-step progressions of NO, NC, CC, and PSC were 14.3%, 16.1%, 8.8%, and 8.1%, respectively, and two-step or more progressions were 5.0%, 6.0%, 0.8%, and 6.0%, respectively. Incident NO was seen in patients 50 to 59 (odds ratio [OR] ¼ 3.3), NC in those 50 to 59 (OR ¼ 2.7) and 60 to 69 (OR ¼ 3.9), and CC in those 60 to 69 (OR ¼ 3.3) years old. A lower hemoglobin A 1c (HbA 1c ; OR ¼ 0.7), longer diabetes duration (OR ¼ 1.1), and hyperopia (OR ¼ 4.0) were associated with incident PSC. Women (OR ¼ 1.7) and patients with higher total cholesterol (OR ¼ 1.3) at baseline showed one-step NO progression. Patients 60 to 69 (OR ¼ 2.8) and ‡70 (OR ¼ 3.8) years old showed one-step NC progression, while those 60 to 69 years old showed one-step CC progression (OR ¼ 6.3). A lower HbA 1c (OR ¼ 0.3) was associated with one-step PSC progression. A higher low-density lipoprotein (OR ¼ 1.6) was associated with two-step or more NO progression. Patients 60 to 69 years old (OR ¼ 6.7) had a greater risk, while those with hyperopia at baseline (OR ¼ 0.2) had lower risk of two-step or more NC progression. Patients 40 to 49 years old constituted the reference group for all.CONCLUSIONS. The 4-year cumulative incidence of cataract is higher than that of progression. Greater age is a risk factor for incidence and progression of most types of cataract.

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Prevalence and Risk Factors for Cataract in Diabetes: Sankara Nethralaya Diabetic Retinopathy Epidemiology and Molecular Genetics Study, Report No. 17

Abstract: Nearly two thirds of the diabetic population showed evidence of cataract; mixed cataracts were more common than the monotypes ones.

Cited by 57 publications

References 39 publications

Prevalence of and Factors Associated with Lens Opacities in a Korean Adult Population with and without Diabetes: The 2008–2009 Korea National Health and Nutrition Examination Survey

Prevalence of and Factors Associated with Lens Opacities in a Korean Adult Population with and without Diabetes: The 2008–2009 Korea National Health and Nutrition Examination Survey

Impact of Multimorbidity on Disability and Quality of Life in the Spanish Older Population

Incidence, Progression, and Risk Factors for Cataract in Type 2 Diabetes

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