Prevalence and Risk Factors for the Development of Nonalcoholic Fatty Liver Disease in a Nonobese Chinese Population: the Zhejiang Zhenhai Study

Xu, Chengfu; Yu, Chaohui; Ma, Yuyuan; Xu, Lei; Miao, Min; Li, Youming

doi:10.1038/ajg.2013.104

Cited by 159 publications

(165 citation statements)

References 31 publications

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“…Risk factors for the development of NAFLD were assessed in a subsequent prospective study in NAFLD-free individuals at baseline, 494 of who had developed NAFLD during the 5-year followup. Prevalence of NAFL was found to be 7.27% [9] .…”

Section: Epidemiologymentioning

confidence: 99%

Role of diet on non-alcoholic fatty liver disease: An updated narrative review

Papandreou

Andreou

2015

WJH

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The purpose of this article review is to update what is known about the role of diet on non-alcoholic fatty liver disease (NAFLD). NAFLD is the most common cause of chronic liver disease in the developed world and is considered to be a spectrum, ranging from fatty infiltration of the liver alone (steatosis), which may lead to fatty infiltration with inflammation known as non alcoholic steatohepatitis While the majority of individuals with risk factors like obesity and insulin resistance have steatosis, only few people may develop steatohepatitis. Current treatment relies on weight loss and exercise, although various insulin-sensitizing medications appear promising. Weight loss alone by dietary changes has been shown to lead to histological improvement in fatty liver making nutrition therapy to become a cornerstone of treatment for NAFLD. Supplementation of vitamin E, C and omega 3 fatty acids are under consideration with some conflicting data. Moreover, research has been showed that saturated fat, trans-fatty acid, carbohydrate, and simple sugars (fructose and sucrose) may play significant role in the intrahepatic fat accumulation. However, true associations with specific nutrients yet to be clarified.

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Section: Epidemiologymentioning

confidence: 99%

Role of diet on non-alcoholic fatty liver disease: An updated narrative review

Papandreou

Andreou

2015

WJH

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“…29,34 Increasing age may also impact the risk of NASH and fibrosis, but data on sex are, again, inconsistent. Middle-aged and elderly individuals have a higher prevalence of fibrosing NASH.…”

Section: 15mentioning

confidence: 99%

“…[21][22][23][24][25][26] Other studies, although confirming that men are at higher risk of NAFLD, have shown an inverse association between NAFLD and age. [27][28][29][30] Conversely, in women, advancing age, menopausal status and MetS features are all independent predictors of NAFLD. 31,32 The lower prevalence of NAFLD which has been reported with advancing age in the elderly, 33 is potentially attributable to either selective mortality or development of cirrhosis (which generally loses steatosis).…”

Section: 15mentioning

confidence: 99%

Epidemiological modifiers of non-alcoholic fatty liver disease: Focus on high-risk groups

Lonardo

Bellentani

Argo

et al. 2015

Digestive and Liver Disease

399

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We aimed to illustrate the epidemiology of nonalcoholic fatty liver disease in high-risk groups, which were identified based on existing literature. To this end, PubMed was searched to retrieve original articles published through May 2015 using relevant and pertinent keywords "nonalcoholic fatty liver disease" and "diabetes", "obesity", "hyperlipidemia", "familial heterozygous hypobelipoproteinemia", "hypertension", "metabolic syndrome", "ethnicity", "family history" or "genetic polymorphisms".We found that age, sex and ethnicity are major physiologic modifiers of the risk of nonalcoholic fatty liver disease, along with belonging to "nonalcoholic fatty liver disease families" and carrying risk alleles for selected genetic polymorphisms. Metabolic syndrome, diabetes, obesity, mixed hyperlipidaemia and hypocholesterolemia due to familial hypobetalipoproteinaemia are the major metabolic modifiers of nonalcoholic fatty liver disease risk. Compared to these metabolic conditions, however, arterial hypertension appears to carry a relatively more modest risk of nonalcoholic fatty liver disease.A better understanding of the epidemiology of nonalcoholic fatty liver disease may result in a more liberal policy of case finding among high-risk groups.

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“…In addition, our study showed involvement of other factors which have also been proposed as indices of oxidant stress status, namely serum hemoglobin levels were significantly and independently associated with GGT activity (inversely) and albumin concentration (positively), while OC correlated with bilirubin level. Hemoglobin [116,117], albumin [118][119][120] and bilirubin [118,121] exhibit potent antioxidant properties. Increases in GGT activity may reflect the responses of counteracting mechanisms to protect against oxidative damage.…”

Section: Potential Mechanisms: Combining Regulatory Elementsmentioning

confidence: 99%