Prevalence and risk factors for primary open-angle glaucoma in a rural northeast China population: a population-based survey in Bin County, Harbin

Sun, Jianhong; Zhou, Xinrong; Yang, Kang; Liu, Yan; Sun, Xinghuai; Sui, Hong; Qin, Dandan; Yuan, Huiping

doi:10.1038/eye.2011.243

Cited by 61 publications

(49 citation statements)

References 40 publications

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“…This finding concurred with results found in most other studies of Chinese people that used the ISGEO criteria for defining glaucoma, except for the Bin County study, 3 which found the converse (1.6% vs 0.7%). In a pooled meta-analysis of epidemiologic studies of glaucoma performed in mainland China, 22 the prevalence of POAG was much lower than that of PACG (0.7% vs 1.4%).…”

Section: Discussionsupporting

confidence: 93%

The Prevalence and Types of Glaucoma in an Urban Chinese Population

et al. 2015

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IMPORTANCE Glaucoma represents a major public health challenge in an aging population. The Tanjong Pagar Eye Study reported the prevalence and risk factors of glaucoma in a Singapore Chinese population in 1997, which established the higher rates of blindness in this population.OBJECTIVES To determine the prevalence and associated risk factors for glaucoma among Chinese adults in Singapore and to compare the results with those of the 1997 study. DESIGN, SETTING, AND PARTICIPANTS In a population-based survey of 4605 eligible individuals, we selected 3353 Chinese adults 40 years or older from the southwestern part of Singapore. Participants underwent examination at a single tertiary care research institute from February 9, 2009, through December 19, 2011. EXPOSURES All participants underwent slitlamp ophthalmic examination, applanation tonometry, measurement of central corneal thickness, gonioscopy, and a dilated fundus examination. MAIN OUTCOMES AND MEASURES Glaucoma as defined by the International Society of Geographical and Epidemiological Ophthalmology guidelines and age-standardized prevalence estimates computed as per the 2010 Singapore Chinese census. Blindness was defined as logMAR visual acuity of 1.00 (Snellen equivalent, 20/200 or worse).RESULTS Of the 3353 respondents, 134 (4.0%) had glaucoma, including primary open-angle glaucoma (POAG) in 57 (1.7%), primary angle-closure glaucoma (PACG) in 49 (1.5%), and secondary glaucoma in 28 (0.8%). The age-standardized prevalence (95% CI) of glaucoma was 3.2% (2.7%-3.9%); POAG, 1.4% (1.1%-1.9%); and PACG, 1.2% (0.9%-1.6%). In a multivariate model, POAG was associated with being older and male and having a higher intraocular pressure. Of the 134 participants with glaucoma, 114 (85.1%; 95% CI, 78.1%-90.1%) were not aware of their diagnosis. Prevalence (95% CI) of blindness caused by secondary glaucoma was 14.3% (5.7%-31.5%), followed by 10.2% (4.4%-21.8%) for PACG and 8.8% (3.8%-18.9%) for POAG. We could not identify a difference in the prevalence of glaucoma compared with the 3.2% reported in 1997 (difference, −0.04%; 95% CI, −1.2 to 1.2; P = .97). CONCLUSIONS AND RELEVANCEThe prevalence of glaucoma among Singapore Chinese likely ranges from 2.7% to 3.9%, with secondary glaucoma being the most visually debilitating type. We could not identify a difference compared with previous studies approximately 12 years earlier. We report a high proportion of previously undiagnosed disease, suggesting the need to increase public awareness of this potentially blinding condition.

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Section: Discussionsupporting

confidence: 93%

The Prevalence and Types of Glaucoma in an Urban Chinese Population

et al. 2015

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“…These results indicate that a positive family history of glaucoma in patients with POAG reflects the influence of genetic variants predisposing to POAG. The present study supports the findings of previous reports [1][2][3][4][5][6] showing that a positive family history of glaucoma is a risk factor for POAG and suggests that genetic factors rather than familial factors may be considered to play important roles in the pathogenesis of POAG. Moreover, we investigated the associations between genetic variants predisposing to POAG and the number or degree of relatives with glaucoma.…”

Section: The Present Study Demonstrated a High Prevalencesupporting

confidence: 94%

Involvement of Genetic Variants Associated With Primary Open-Angle Glaucoma in Pathogenic Mechanisms and Family History of Glaucoma

Mabuchi

Sakurada

Kashiwagi

et al. 2015

American Journal of Ophthalmology

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“…Previously study showed sex hormone was not associated with glaucoma. [19,20] With respect to SG, including traumatic glaucoma and neovascular glaucoma, males were more prevalent than females (M/F 1.75:1). SG falls into 2 major categories: one is traumatic glaucoma related to male violence, the other is neovascular glaucoma which has a close relationship with chronic metabolic disorders, such as obesity and type 2 diabetes.…”

Section: Discussionmentioning

confidence: 99%

Epidemiologic characteristics of 10 years hospitalized patients with glaucoma at shanghai eye and ear, nose, and throat hospital

2016

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To analyze the epidemiologic characteristics of hospitalized patients with glaucoma at Shanghai Eye and Ear, Nose, and Throat Hospital in the relative well economic condition area Eastern China.Researchers reviewed the 10 years charts of patients with a discharge diagnosis of glaucoma at this hospital from January 2004 to December 2013. With the criteria used for diagnoses of different types of glaucoma, the constitution of this disease between the first and last 5 years was compared and analyzed.A total of 11,864 cases were enrolled according to the criteria of diagnoses for 10 years. Primary angle-closure glaucoma (PACG) was the main type (51.69%) followed by secondary glaucoma (SG, 28.14%), primary open-angle glaucoma (POAG) (10.41%), and congenital glaucoma (7.16%). Other glaucoma types were less prevalent (2.61%). PACG has seen a declining trend (from 57.75% to 48.41%), while the proportion of SG has increased (from 23.68% to 34.21%). For the POAG group, there is no increasing trend and the same is true of CG. The mean age of PACG patients was 62.28 year-old, while it was 46 year-old for the POAG and SG groups. The patients of PACG had more women than men (M/F ratio: 1:1.92). The reverse was the case with regard to POAG (M/F ratio: 1.97:1).In Eastern China, although PACG has some decreased, but still is the most commonly encountered type of glaucoma, while SG has significantly increased, and POAG has slightly decreased in hospitalized patients during recent 10 years.

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Prevalence and risk factors for primary open-angle glaucoma in a rural northeast China population: a population-based survey in Bin County, Harbin

Abstract: POAG is a disease of serious consequence and of low diagnosis and treatment rates in rural northeast China. Age, family history of glaucoma, systemic hypertension, and IOP remain as significant independent risk factors for POAG.

Cited by 61 publications

References 40 publications

The Prevalence and Types of Glaucoma in an Urban Chinese Population

The Prevalence and Types of Glaucoma in an Urban Chinese Population

Involvement of Genetic Variants Associated With Primary Open-Angle Glaucoma in Pathogenic Mechanisms and Family History of Glaucoma

Epidemiologic characteristics of 10 years hospitalized patients with glaucoma at shanghai eye and ear, nose, and throat hospital

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