Prevalence and Risk Factors for Cognitive Frailty in Aging Hypertensive Patients in China

Abstract

Hypertension is one of the most common chronic diseases and a major risk factor for stroke, myocardial infarction and cardiovascular death. Cognitive frailty is an important predictor of all-cause mortality and dementia in aging individuals. Hypertension is closely related to cognitive frailty and these two conditions often coexist in aging individuals. Few studies have explored the relationship between hypertension and cognitive frailty in the Chinese population. This study investigates the epidemiological characteristics of and factors related to cognitive frailty in aging Chinese patients with hypertension. In total, cognitive function, weakness, social support, depression and sociodemographic were assessed in 305 participants aged 60 and over. Univariate and multivariate logistic regression models were constructed. The prevalence of cognitive frailty in aging Chinese hypertensive patients was 9.8% (95% CI = 6.4–13.2%). After adjusting for confounding variables, logistic regression showed that the course of hypertension (6–10 years, OR = 8.588, 95% CI = 1.608–45.859;course of more than 10 years, OR = 9.020, 95%CI = 1.854–43.892), multimorbidity (OR = 11.231, 95% CI = 2.912–43.322), depression (OR = 6.917, 95% CI = 2.424–19.738) and social support (OR = 0.187, 95% CI = 0.071–0.492) were independently associated with cognitive frailty. The prevalence of cognitive frailty in aging patients with hypertension in China should not be ignored. The course of hypertension, multimorbidity and depression are the risk factors of cognitive frailty in the aging population and a better level of social support is the protective factor for cognitive frailty.

Prevalence of cognitive frailty among older adults in China: a systematic review and meta-analysis

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“…A total of 522 studies were obtained from the preliminary search, and after layer-by-layer screening, 28 cross-sectional studies were finally included 19–46. The specific process and results of literature screening are shown in figure 1.…”

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Mediating Effect of Loneliness in the Relationship between Depressive Symptoms and Cognitive Frailty in Community-Dwelling Older Adults

“…The higher scores mean better cognitive function. According to the educational level of participants, illiteracy of ≤17 points, primary school of ≤20 points, junior high school of ≤22 points, and senior high school and above of ≤24 points are diagnosed as MCI [ 28 ].…”

The Correlation Between Falls and Cognitive Frailty in Elderly Individuals With Hypertension in a Chinese Community

“…The 2019 edition of the Chinese guidelines for the management of hypertension in the elderly also emphasizes the importance of assessing CF and adverse outcomes in hypertensive elderly people (Li et al, 2019 ). Our previous study (Wang et al, 2021 ) investigated the prevalence and influencing factors of CF in elderly individuals with hypertension in China. On the basis of that study, we continued to explore the correlation of CF with falls.…”