Prevalence and risk factors for allergic contact dermatitis to topical treatment in atopic dermatitis: a study in 641 children

Mailhol, C.; Lauwers‐Cancès, Valérie; Rancé, F.; Paul, C.; Giordano‐Labadie, F.

doi:10.1111/j.1398-9995.2008.01890.x

Cited by 136 publications

(116 citation statements)

References 24 publications

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“…These may be taken into account as warning points for investigating children with AD for possible contact sensitization. In the literature, the frequency of contact sensitization of children with AD was reported as 6.2% to 89% in different countries worldwide (2)(3)(4)(5)(6)(7). This wide range of frequency may be due to the usage of different contact allergen panels and inclusion of different age groups of children in different studies.…”

Section: Discussionmentioning

confidence: 99%

“…Mailhol et al (6) patch-tested 641 children diagnosed with AD with the 6 active components of their topical AD treatment and with their current emollient, and they found a positive reaction in 40 (6%) children. In their study, while younger age at the time of study, onset of AD before 6 months of age, and IgE sensitization were risk factors for contact sensitization, sex and history of asthma were not associated with the risk of sensitization to topical AD treatment.…”

Section: Discussionmentioning

confidence: 99%

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The patterns and clinical relevance of contact allergen sensitization in a pediatric population with atopic dermatitis

Akan¹,

Toyran²,

Vezir³

et al. 2015

Turk J Med Sci

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Background/aim: Data about contact allergen sensitization (CAS) in children with atopic dermatitis (AD) are limited. The purpose of this study was to identify the frequency and patterns of CAS in children with AD by using a ready-to-use patch test system. Materials and methods:After receiving the history of CAS in the patients, the severity of AD and IgE-mediated allergen sensitization were determined.Results: Of 134 children with AD, 33.8% (n = 45) had at least 1 positive reaction. The most frequent positive reaction was to nickel sulfate (NS) (37.8%, 17/45), followed by methylchloroisothiazolinone (20.0%, 9/45) and thimerosal (15.6%, 7/45). The total Scoring Atopic Dermatitis (SCORAD) score was significantly higher in the NS-sensitized group (P = 0.036). The patients with NS sensitization had moderate-severe AD more frequently than those without any reaction (P = 0.020). When the SCORAD score was evaluated in detail, extent of eczema, score of sleep loss, and pruritus were significantly higher in the patients with NS sensitization than those without any reaction (P = 0.002, P = 0.001, and P = 0.002, respectively). Conclusion:Our study confirms the necessity of CAS in the management of AD. In particular, NS sensitization should be considered for children with severe AD or larger extent of eczema and trunk involvement.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The patterns and clinical relevance of contact allergen sensitization in a pediatric population with atopic dermatitis

Akan¹,

Toyran²,

Vezir³

et al. 2015

Turk J Med Sci

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show abstract

“…As can be expected from frequent exposition to allergens in topical therapy, allergies to lanolin alcohols and antiseptics occur regularly within patients with AD 21, 24. Several specific allergic contact reactions are described to occur more often in AD children compared to healthy children.…”

Section: Introductionmentioning

confidence: 98%

“…Also, potassium dichromate, disperse blue 106 and compositae mix are frequent sensitizers 25. If corticosteroid therapy is not sufficient for treating AD anymore, many dermatologists may suspect an allergy for corticosteroids 24, 26, 27…”

Section: Introductionmentioning

confidence: 99%

Both children and adult patients with difficult‐to‐treat atopic dermatitis have high prevalences of concomitant allergic contact dermatitis and are frequently polysensitized

Boonstra

Rustemeyer

Middelkamp-Hup

2018

Acad Dermatol Venereol

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BackgroundConcomitant allergic contact dermatitis (ACD) has been described as a possible cause of atopic dermatitis (AD) becoming difficult‐to‐treat. However, contact sensitization in this patient group has barely been studied.ObjectiveTo study the occurrence of ACD in a population of difficult‐to‐treat AD children and adults.MethodsClinical and patch test information of 48 patients with difficult‐to‐treat AD unresponsive to conventional outpatient treatments was gathered retrospectively. We studied prevalence and relevance of common allergens, performed dynamic patch test analysis and assessed occurrence of polysensitization.ResultsIn 48 patients with difficult‐to‐treat AD, 75% (n = 36/48) had a concomitant contact allergy, and 39% (n = 14/36) of these patients were polysensitized. ACD and polysensitization prevalences were equal amongst children and adults. The most frequent and relevant reactions were seen against wool alcohols, surfactants cocamidopropyl betaine and dimethylaminopropylamine, bichromate and fragrance mix I. Dynamic pattern analysis showed these reactions to be mostly allergic and not irritative of nature.ConclusionDifficult‐to‐treat AD patients frequently suffer from concomitant (multiple) contact allergies, and this may be a reason why the AD turns into a difficult‐to‐treat disease. Awareness of this phenomenon is necessary, as pragmatic implementation of allergen avoidance strategies may be helpful in getting disease control in this population.

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“…The skin abnormality associated with AD is well known to be a predisposing factor to sensitive skin (Farage, et al, 2006, Willis, et al, 2001) and allergic contact dermatitis (Clayton, et al, 2006, Mailhol, et al, 2009). However, children with atopic dermatitis had lower PPD induration size compared to healthy donors, but this was not statistically significant (Gruber, et al, 2001, Yilmaz, et al, 2000.…”

Section: Altered Immunobiology Response In Flaky Tail Mousementioning

confidence: 99%

Flaky Tail Mouse as a Novel Animal Model of Atopic Dermatitis: Possible Roles of Filaggrin in the Development of Atopic Dermatitis

Moniaga¹,

Kabashima²

2012

Atopic Dermatitis - Disease Etiology and Clinical Management

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Prevalence and risk factors for allergic contact dermatitis to topical treatment in atopic dermatitis: a study in 641 children

Cited by 136 publications

References 24 publications

The patterns and clinical relevance of contact allergen sensitization in a pediatric population with atopic dermatitis

The patterns and clinical relevance of contact allergen sensitization in a pediatric population with atopic dermatitis

Both children and adult patients with difficult‐to‐treat atopic dermatitis have high prevalences of concomitant allergic contact dermatitis and are frequently polysensitized

Flaky Tail Mouse as a Novel Animal Model of Atopic Dermatitis: Possible Roles of Filaggrin in the Development of Atopic Dermatitis

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