Prevalence and risk factors for asymptomatic bacteriuria in women with Type 2 diabetes mellitus

Ishay, Avraham; Lavi, Idit; Luboshitzky, Rafael

doi:10.1111/j.1464-5491.2005.01758.x

Cited by 40 publications

(50 citation statements)

References 28 publications

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“…26,27 In our study also ASB had a statistically significant association with proteinuria with p<0.05. 20 also showed that macroalbuminuria was an independent and significant risk factor for ASB in type 2 Diabetes Mellitus women which was reiterated by our study as well…”

Section: Discussionsupporting

confidence: 66%

“…In agreement to our results, Sunnesh Reddy et al and Nicolle LE et al in their study had also showed that patients with long standing diabetes mellitus had increased risk of ASB; however, Ishay et al in their study did not find any association between these two. 13,19,20 Collee JG et al in their study stated uncontrolled blood sugar level as an important risk factor for ASB in diabetic patient. 21 The high prevalence of ASB among diabetics in our study may be due to uncontrolled blood sugar level.…”

Section: Discussionmentioning

confidence: 99%

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Asymptomatic bacteriuria and its associated factors in type II diabetes mellitus

et al. 2017

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INTRODUCTIONDiabetes mellitus and its complications have great socioeconomic and health implications on human society.1 Type II diabetes mellitus which is a complex endocrine and metabolic disorder is characterized by the interaction of several genetic and environmental factors resulting in a heterogeneous and progressive disorder with variable degrees of insulin resistance and pancreatic β-cell dysfunction.2 The magnitude of the diabetic epidemic can be judged by its global prevalence estimated at around 194 million people and with the prevalence of diabetes in India alone expected to increase ABSTRACT Background: With the dawn of modern era the diabetes epidemic has spread over continents affecting the developed and the developing nations alike. Asymptomatic bacteriuria which is quite prevalent in the diabetic population is associated with increased diabetic complications and thereby increased morbidity. Thus, the aim of this study was to assess the proportion of cases with asymptomatic bacteriuria (ASB) among type II diabetes mellitus patients as compared to non-diabetic healthy controls and studying the factors associated with ASB. Methods: 93 eligible type II diabetes mellitus cases without genitourinary symptoms or abnormalities along with 93 non-diabetic healthy controls were recruited. Mid-stream urine was collected after taking informed consent and each sample tested using the dipstick, microscopy and culture techniques. Isolates were identified using standard biochemical tests. Results: Prevalence of ASB in our study was found to be 34.4% among cases of type II diabetes mellitus while it was 6.45% among non-diabetic healthy controls. Amongst the diabetics with ASB 71.9 % were females and 28.13 % were males. E. Coli was isolated in 21 subjects among diabetic cases (22.58%) and in 5 subjects among non-diabetic healthy controls (5.38%). Fasting blood sugar (FBS) in diabetic cases group was 151.08 ± 48.16 and in control group was found to be 98.57 ± 25.95 (p<0.001). Mean duration of patients with DM who had ASB (32) was 8.46 ± 4.14 years and those who were culture negative was 4.59 ± 4.2 years (p < 0.05). 24 subjects (75%) out of 32 diabetic ASB cases had glycosuria compared to 27 subjects (44.26%) out of 61 culture negative cases (p < 0.05). 9 out of 32 (28.13%) diabetic ASB subjects had proteinuria compared to 4 out of 61 (6.56%) culture negative cases (p < 0.05). Conclusions: Overall prevalence of ASB was significantly more in diabetic population as compared to non-diabetic healthy controls (34.4% vs 6.45%). Females have an increased likelihood of developing ASB as compared to males. E. Coli was the most common pathogen isolated in ASB cases. Longer duration of diabetes and poor glycemic control are independent predictors for the development of ASB. The risk of ASB is also significantly increased in those with glycosuria and proteinuria.

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Section: Discussionsupporting

confidence: 66%

Section: Discussionmentioning

confidence: 99%

Asymptomatic bacteriuria and its associated factors in type II diabetes mellitus

et al. 2017

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“…7,12 The prevalent microorganisms (Table 2) in the present study were coagulase negative Staphylococcus (36.3%), Klebsiella sp (15.9%), Candida sp (13.7%), E. coli and Serratia sp (10.8% each). This is contrary to other studies 5,7,8,9 where E. coli was the predominant bacteria. The predominance of bacteria other than E. coli in the urinary tract is increasingly being reported.…”

Section: Discussioncontrasting

confidence: 55%

“…5,6,7 On the contrary, another study 8 reported no significant difference in the prevalence of ASB between diabetic women and non-diabetic women (P = 0.07).…”

Section: Introductionmentioning

confidence: 68%

Asymptomatic bacteriuria in diabetes mellitus patients in Southwest Cameroon

Bissong¹,

Fon²,

Tabe-Besong³

et al. 2013

Afr H. Sci.

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Background: Asymptomatic bacteriuria (ASB) is common in diabetics and predisposes these patients to more severe urinary tract infections (UTIs). Reports on the prevalence and etiology of ASB especially in developing countries appear contradictory. Objectives: To determine the prevalence and etiology of ASB and antimicrobial resistance of urinary isolates in diabetics and non-diabetics. Methods: The study involved a total of 265 participants including 154 diabetes mellitus patients and 111 non-diabetics in Southwest Cameroon. Mid-stream urine was collected from consented subjects and each sample tested using the dipstick, microscopy and culture techniques. Isolates were identified using standard biochemical tests. Results: ASB was detected in 33.2% of participants; 38.3% in diabetics and 26.1% in non-diabetics (P = 0.03). Coagulasenegative staphylococci (CNS) were the predominant organisms (36.3%) isolated from urine in both diabetics and nondiabetics. Other isolates included Klebsiella sp (15.9%), Candida sp (13.7%), E. coli (10.8%) and Serratia sp (10.8%). Candida sp was isolated more from diabetics than non-diabetics (P = 0.01). There was no significant difference in resistance between diabetics and non-diabetics (P > 0.05). Most isolates showed multiple resistance and ciprofloxacin was the most active ingredient against bacterial uropathogens. Conclusion: The study revealed a high prevalence of ASB in diabetics than in non-diabetics. A change in the aetiologic spectrum was observed with Staphylococcus sp accounting for majority of ASB. Most isolates showed multiple resistance in both diabetics and non-diabetics; therefore the need to speed up sensitization against antibiotic abuse in Southwest Cameroon.

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“…This was unlike what Ishay A et al described in 2006, who found serum creatinine as an independent risk factor for ASB. 14 Diabetic patients with Nephropathy had 3.5 times risk of getting ASB as compared with patients who had no nephropathy. However, this figure was not statistically significant (95%, CI = .681 -18.387).…”

Section: Discussionmentioning

confidence: 92%

Study on Asymptomatic Bacteriuria in Elderly Diabetic Women

Rao¹,

Murthy²,

Aparna³

et al. 2017

jemds

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BACKGROUNDPrevalence of diabetes mellitus and asymptomatic bacteriuria is increasing drastically in developing countries, particularly in India. In the present study, an attempt has been made to find an association of the asymptomatic bacteriuria and diabetes mellitus type 2.The aim of this study is to estimate the prevalence of asymptomatic bacteriuria in elderly diabetic women. To assess if obstructive uropathy/ diabetic cystopathy has an association with asymptomatic bacteriuria in older diabetic women. To assess if other clinical and laboratory factors such as HbA1C, duration of diabetes, body mass index, etc. have an association with asymptomatic bacteriuria.

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Prevalence and risk factors for asymptomatic bacteriuria in women with Type 2 diabetes mellitus

Cited by 40 publications

References 28 publications

Asymptomatic bacteriuria and its associated factors in type II diabetes mellitus

Asymptomatic bacteriuria and its associated factors in type II diabetes mellitus

Asymptomatic bacteriuria in diabetes mellitus patients in Southwest Cameroon

Study on Asymptomatic Bacteriuria in Elderly Diabetic Women

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