Prevalence and risk factors associated with severe pre-eclampsia among postpartum women in Zanzibar: a cross-sectional study

Machano, Mwashamba Mussa; Joho, Angelina A.

doi:10.1186/s12889-020-09384-z

Cited by 30 publications

(22 citation statements)

References 23 publications

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“…Inour study analysis, we found 62 percent of cases of pre-eclampsia in patientsadmitted as a case of peripartum cardiomyopathy (PPCM). This prevalence of pre-eclampsia in PPCM is significantly higher than the average global the prevalence that is 2-8% [9,10]. Pre-eclampsia is associated with significant changes in the cardiovascular system.…”

Section: Discussionmentioning

confidence: 79%

Association of Peripartum Cardiomyopathy with Pre-eclampsia and Maternal Outcome

Abbas

Yousfani

Shaikh

et al. 2021

JPRI

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Objective: To determine the Prevalence of Pre-eclampsia in women with peripartum cardiomyopathy (PPCM) and to compare the maternal outcome in cases of PPCM who develop pre-eclampsia with those cases who are normotensive. Study design: This is a prospective observational study. Setting: Study carried out at department of Gynecology and Obstetrics, Liaquat university hospital Hyderabad from 20th February 2019 to 19th February 2020. Materials and methods: This prospective observational study was conducted in department of Gynecology and Obstetrics and department of Cardiology Liaquat University Hospital Hyderabad. Inclusion criteria were patients admitted with a diagnosis of peripartum cardiomyopathy diagnosed clinically and confirmed by echocardiography. Exclusion criteria were cases with multiple pregnancies, smokers, those with chronic hypertension and chronic renal disease or diabetes. We assessed patients for pre-eclampsia. Outcome measures studied were serious maternal complications like Pulmonary oedema, Cardiogenic shock, intensive care unit admission, and death. Results: During one year study period, there were 71 cases of peripartum cardiomyopathy. The mean age of patients was 29.77±6.8 years. Pre-eclampsia was seen in 62% cases of Peripartum cardiomyopathy. Mean ejection fraction was 33.24±6.49. In patients of PPCM, serious maternal complications including cardiogenic shock 11(15.5%) cases, intensive care unit admission 10(14.1%) cases, pulmonary oedema 35(49.3%) cases and prolonged hospitalization 58(81.7%) cases. Conclusion: We conclude that pre-eclampsia has high prevalence in patients with PPCM. Both when combined, significantly increase the chances of serious maternal complications including death.

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Section: Discussionmentioning

confidence: 79%

Association of Peripartum Cardiomyopathy with Pre-eclampsia and Maternal Outcome

Abbas

Yousfani

Shaikh

et al. 2021

JPRI

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“…High parity (> 3 times childbirth) is a risk of preeclampsia due to a decrease in the function of the reproductive system and/or because the mother is busy taking care of the household and causes fatigue so that the mother is unable to meet her nutritional needs. Another study conducted in coastal Africa found a result of p = 0.088 where the dominant group of preeclamptic pregnant women was in the multiparous and grand multipara group, not in the primigravida group (Machano & Joho, 2020).…”

Section: Discussionmentioning

confidence: 96%

Differences of heparin binding protein levels in preeclampsian and non preeclampsian women

Layuk

Wahyuni

Arifuddin

2021

ijhs

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This study aims to the incidence of preeclampsia and determine differences in heparin-binding protein levels in preeclamptic and non-preeclamptic mothers and determine the relationship between urinary tract infections in pregnancy. The research design was cross-sectional on 65 respondents with an accidental sampling technique. The research data were obtained from a questionnaire containing a list of questions given to respondents, measurement of middle urine samples to measure nitrite, leukocytes urine using dipstick method, and to determine heparin binding protein (HBP) levels using the ELISA method in the Hasanuddin University RSP Research Laboratory. The results of the study found there was a difference in the levels of heparin-binding protein in pregnant women without preeclampsia, namely 1.90±0.22 Ng/ml and HBP levels in pregnant women preeclampsia ie 2.39±0.3 Ng/ml. That there was no significant relationship between urinary tract infections (UTI) and the incidence of preeclampsia with p= 0.074. The conclusion in this study is that the levels of heparin-binding protein differ in preeclamptic and non-preeclamptic mothers, the increase in HBP levels in preeclampsia is due to inflammation, the cause is not through UTI. There is no association between urinary tract infections in pregnant women and the incidence of preeclampsia.

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“…This is an observation that is not consistently found in previous studies, though it was also observed in the Maputo study ( 10 ). Hypertensive disorders of pregnancy appear to be very prevalent in Zanzibar ( 24 , 25 ) and increase the risk of stroke later in life ( 26 ) which could contribute to the higher incidence rate among younger women. This poses a serious health concern and needs further investigation in future research.…”

Section: Discussionmentioning

confidence: 99%

Incidence and characteristics of stroke in Zanzibar–a hospital-based prospective study in a low-income island population

et al. 2022

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BackgroundStroke in adults is a critical clinical condition and a leading cause of death and disability globally. Epidemiological data on stroke in sub-Saharan Africa are limited. This study describes incidence rates, stroke types and antecedent factors among patients hospitalized with stroke in Zanzibar.MethodsThis was a prospective, observational study of stroke patients at hospitals in Unguja, Zanzibar. Socioeconomic and demographic data were recorded alongside relevant past medical history, medicine use and risk factors. The modified National Institute of Health Stroke Scale (mNIHSS) was used to assess admission stroke severity and, when possible, stroke was confirmed by neuroimaging.ResultsA total of 869 stroke admissions were observed from 1st October 2019 through 30th September 2020. Age-standardized to the World Health Organization global population, the yearly incidence was 286.8 per 100,000 adult population (95%CI: 272.4–301.9). Among these patients, 720 (82.9%) gave consent to participate in the study. Median age of participants was 62 years (53–70), 377 (52.2%) were women, and 463 (64.3%) had a first-ever stroke. Known stroke risk factors included hypertension in 503 (72.3%) patients, of whom 279 (55.5%) reported regularly using antihypertensive medication, of whom 161 (57.7%) had used this medication within the last week before stroke onset. A total of 460 (63.9%) participants had neuroimaging performed; among these there was evidence of intracerebral hemorrhage (ICH) in 140 (30.4%). Median stroke severity score using mNIHSS was 19 (10–27).ConclusionZanzibar has high incidence of hospitalization for stroke, indicating a very high population incidence of stroke. The proportion of strokes due to ICH is substantially higher than in high-income countries. Most stroke patients had been in contact with health care providers prior to stroke onset and been diagnosed with hypertension. However, few were using antihypertensive medication at the time of stroke onset.www.ClinicalTrial.gov registration NCT04095806.

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Prevalence and risk factors associated with severe pre-eclampsia among postpartum women in Zanzibar: a cross-sectional study

Cited by 30 publications

References 23 publications

Association of Peripartum Cardiomyopathy with Pre-eclampsia and Maternal Outcome

Association of Peripartum Cardiomyopathy with Pre-eclampsia and Maternal Outcome

Differences of heparin binding protein levels in preeclampsian and non preeclampsian women

Incidence and characteristics of stroke in Zanzibar–a hospital-based prospective study in a low-income island population

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