Prevalence and risk factors analysis of bovine tuberculosis in cattle raised in mixed crop‐livestock farming system in Tigray region, Ethiopia

Habitu, Takele; Areda, Demelash B.; Muwonge, Adrian; Tessema, Girum Tadesse; Skjerve, Eystein; Gebremedhin, Tadesse

doi:10.1111/tbed.13050

Cited by 14 publications

(13 citation statements)

References 23 publications

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“…Many risk factors were responsible for occurrence of disease in animals include cattle breed, age. also host independent factors are considered more important and include herd size, management practices and cattle purchasing (5)(6)(7)(8)(9). Diagnosis of BTB in live animal depends on tuberculin test; the standard method is the comparative intradermal tuberculin (CIDT) test which based on delayed hypersensitivity (10).…”

Section: Introductionmentioning

confidence: 99%

Prevalence and risk factors of bovine tuberculosis in dairy cattle farms in Egypt

Hamed¹,

Nasr²,

Azooz³

et al. 2021

IJVS

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A cross-sectional study was carried out from November, 2015 to April, 2018 to determine the prevalence and identify the risk factors of BTB using the comparative intradermal tuberculin (CIDT) test on 5327 dairy cattle in 16 dairy herds in mid-delta, Alexandria Road and Upper Egypt districts. Questionnaires used to collect data on herd size and management. The herd and individual animal prevalence at cut-off ≥4mm were 68.75% (95%, CI: 46 to 91.4) and1.67% (95%, CI: 1.3to 2.1) respectively. The individual prevalence was significantly associated with age, breed and different location of farms and density of cattle in yard. On herd level, history of BTB in the farm, management practices, raising of different species in the same facility and newly purchased cattle are important risk factors for BTB. The postmortem examination of positive reactors revealed 66 (85.71%) out of 77slaughtered cattle with visible lesions and 11(14.29%) with non-visible lesions. Bacteriological examination revealed 74.24% (49/66) from visible lesions and 9.09% (1/11) from non-visible lesions were Mycobacterium bovis. The indirect enzyme linked immunosorbent assay (IELISA) results revealed 31(40.26%) showed positive result including 29 (93.6%) visible lesions and 2(6.4%) nonvisible lesions. In conclusion, the prevalence high in herds with poor management condition, raised different species in the same facility, had previous history of BTB infection and purchased new animals. At animal level Holstein breed, 3-6 years age, kept in high density and located in mid-delta district were at higher risk to be reactor to comparative intradermal tuberculin (CIDT) test.

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Section: Introductionmentioning

confidence: 99%

Prevalence and risk factors of bovine tuberculosis in dairy cattle farms in Egypt

Hamed¹,

Nasr²,

Azooz³

et al. 2021

IJVS

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“…In a cross-sectional study of bTB in Ethiopia, exotic cattle were more likely to be bTB positive using the comparative cervical intradermal tuberculin test (CIDT) than local cattle breeds (Habitu et al, 2019). A meta-analysis of bTB in Ethiopia also found that Holstein-Friesians have a higher bTB prevalence than local zebu [prevalence = 21.6% (95% CI: 14.7-30.7); prevalence = 4.1% (95% CI: 3.4-4.9), respectively (Sibhat et al, 2017)].…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, Ameni et al (2007) found that Holsteins had more severe bTB pathology than zebu cattle in Ethiopia. Therefore, the use of and/or crossbreeding with taurine dairy cattle and the intensification of farming is likely to increase the incidence of bTB (Habitu et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

Genetic Diversity of Cameroon Cattle and a Putative Genomic Map for Resistance to Bovine Tuberculosis

et al. 2020

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Bovine Tuberculosis (bTB) caused by Mycobacterium bovis is a livestock disease of global economic and public health importance. There are currently no effective vaccines available for livestock and so control relies on animal level surveillance and pasteurization of dairy products. A new alternative control approach is to exploit the genetic variability of the host; recent studies have demonstrated that breeding European taurine cattle, such as Holsteins for increased resistance to bTB is feasible. The utility of such an approach is still unknown for African cattle populations. This study aims to assess genetic variation in bTB resistance and the underlying genomic architecture of cattle in Cameroon. We conducted a cross-sectional study of 2,346 slaughter cattle in Cameroon. Retropharyngeal lymph node samples were collected and cultured on Lowenstein Jensen media and the BACTEC MGIT 960 system, and M. bovis was identified using the Hain® Genotype kits. A total of 153 cattle were positive for M. bovis and were archived along with a random selection of negative samples. In this study, we genotyped archived samples from 212 cattle. Their genomic diversity was characterized using PCA, hierarchical clustering and admixture analysis. We assessed genetic variation in bTB resistance using heritability analysis and compared quantitative trait loci. Previous research on this study population have shown that Fulani cattle are more susceptible to bTB than mixed breeds. However, here we show that these apparent phenotypic differences in breeds are not reflected by clear genomic differences. At the genetic level, both the Fulani and mixed cattle show similar patterns of admixture with evidence of both taurine and indicine ancestry. There was little European taurine introgression within the studied population. Hierarchical clustering showed clusters of cattle that differed in their susceptibility to bTB. Our findings allude to bTB resistance being polygenic in nature. This study highlights the potential for genetic control of bTB in Africa and the need for further research into the genetics of bTB resistance within African cattle populations.

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“…In a cross-sectional study of bTB in Ethiopia, exotic cattle were more likely to be bTB positive using the comparative cervical intradermal tuberculin test (CIDT) than local cattle breeds (Habitu et al, 2019). A meta-analysis of bTB in Ethiopia also found that Holstein-Frisians have a higher bTB prevalence than local zebu (prevalence = 21.6% (95% CI: 14.7–30.7); prevalence = 4.1% (95% CI: 3.4–4.9), respectively) (Sibhat et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

“…(Ameni et al, 2007) found that Holsteins had more severe bTB pathology than zebu cattle in Ethiopia. Therefore the use of and/or crossbreeding with taurine dairy cattle and the intensification of farming is likely to increase the incidence of bTB (Habitu et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

A putative genomic map for resistance ofBos indicuscattle in Cameroon to bovine tuberculosis

Callaby

Kelly

Mazeri

et al. 2020

Preprint

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2Bovine Tuberculosis (bTB) caused by Mycobacterium bovis is a livestock disease of global 3 economic and public health importance. There are currently no effective vaccines available for 4 livestock and so control relies on animal level surveillance and pasteurisation of dairy products. A 5 new alternative control approach is to exploit the genetic variability of the host; recent studies 6 have demonstrated that breeding Bos taurus cattle for increased resistance to bTB is feasible. 7 The utility of such an approach is still unknown for the Bos indicus cattle population. This study 8 aims to assess genetic variation in bTB resistance and the underlying genomic architecture in 9 Bos indicus breeds in Cameroon. 10 We conducted a cross-sectional study of slaughter cattle in Cameroon and genotyped a sample 11 of 213 cattle. Their genomic diversity was characterised using PCA, hierarchical clustering and 12 admixture analysis. We assessed genetic variation in bTB resistance using heritability analysis 13 and compared quantitative trait loci. 14 Previous studies had found that breed was an important factor in explaining the epidemiology 15 of bTB, with Fulani cattle appearing to be more susceptible than mixed breeds. However, we 16 show that the apparent phenotypic differences in visual appearance between the breeds was 17 not reflected by clear genomic differences. At the genetic level, cattle belonging to different 18 hierarchical genomic clusters differed in their susceptibility to bTB. There was evidence of a 19 genomic association between M. bovis infection status with specific SNPs. 20 We highlight the need to understand the challenges faced by livestock in specific settings both 21 in terms of pathogens and the environment, in addition to their intended purpose and how they 22 fit into a defined management system. It is only at this point livestock keepers can then make 23 informed breeding choices, not only for resistance to disease but also for increasing production. 24

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Prevalence and risk factors analysis of bovine tuberculosis in cattle raised in mixed crop‐livestock farming system in Tigray region, Ethiopia

Abstract: Prevalence and risk factors analysis of bovine tuberculosis in cattle raised in mixed crop-livestock farming system in Tigray region, Ethiopia', Transboundary and Emerging Diseases.

Cited by 14 publications

References 23 publications

Prevalence and risk factors of bovine tuberculosis in dairy cattle farms in Egypt

Prevalence and risk factors of bovine tuberculosis in dairy cattle farms in Egypt

Genetic Diversity of Cameroon Cattle and a Putative Genomic Map for Resistance to Bovine Tuberculosis

A putative genomic map for resistance ofBos indicuscattle in Cameroon to bovine tuberculosis

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