Prevalence and relative risk of Rotavirus Gastroenteritis in children under five years in Nigeria: a systematic review and meta-analysis

Digwo, Daniel C.; Chidebelu, Paul; Ugwu, Kenneth; Adediji, Adedapo Olutola; Farkas, Kata; Chigor, Vincent N.

doi:10.1080/20477724.2022.2043223

Cited by 3 publications

(2 citation statements)

References 60 publications

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“…There was a statistical difference among nationality group (P < 0.05). The G type (VP7) produced seven (7) different strains of VP7 detected were G1, G2, G4, G8, G9, G10 and G12. The most predominant G genotype observed was G4 with a prevalence of 26.7 % (16/60), followed by G9 20 % (12/60).…”

Section: Rotavirus Infection and Socio-demographic Factorsmentioning

confidence: 99%

Molecular Characterization and Risk Factors Associated with Rotavirus among Children with diarrhoea.

Demekong,

Onu,

Okorie

et al. 2024

Preprint

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Introduction: Rotavirus-induced acute diarrhoea continues to pose a significant health threat to children under 5 years old worldwide, despite the availability of effective vaccines. This study aimed to assess the prevalence, associated risk factors, and circulating genotypes of rotavirus among children under 5 admitted to Ikom Medical Centre due to diarrhea. Methodology: Stool samples were collected from 294 children under 5 with diarrhoea at Ikom Medical Centre. Rotavirus antigen detection was performed using rapid chromatographic immunoassay. Molecular techniques such as polyacrylamide gel electrophoresis (PAGE), RT-PCR, and semi-nested multiplex RT-PCR were used to analyze rotavirus strains. Data were obtained through questionnaires, and statistical significance was assessed using the chi-square test (P < 0.05). Results: Among the 294 samples, 20.4% (60/294) tested positive for rotavirus. Significant risk factors influencing rotavirus prevalence included feeding status, toilet system, and duration of diarrhoea. The most prevalent genotype for VP7 was G4 (26.7%), and for VP4, it was genotype P[4] (23.3%). Predominant genotype combinations were G4P [4] (11.6%) and G12P[4] (6.7%), while non-typeable P[NT] was observed in 41.7% of cases. Conclusion: This study highlights the circulation of rotavirus in Ikom, Cross River State, emphasizing its neglected status despite its significant global impact on child mortality. Urgent attention is needed to address rotavirus as a serious public health concern, particularly in low-resource settings.

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Section: Rotavirus Infection and Socio-demographic Factorsmentioning

confidence: 99%

Molecular Characterization and Risk Factors Associated with Rotavirus among Children with diarrhoea.

Demekong,

Onu,

Okorie

et al. 2024

Preprint

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“…In, Nigeria, rotavirus, human adenovirus (HAdV), norovirus (NoV), human astrovirus (HAstV), and hepatitis A virus (HAV) are some of the leading EVs commonly implicated in cases of viral gastroenteritis (4,5). In 2016, epidemiological data on the disease burden of EVs in Nigeria showed that rotavirus infection within the country accounted for 14% of deaths in the global children under five mortality indices (6). The annual mortality associated with rotavirus infection within the country resulted in an intervention that led to the introduction of the rotavirus vaccine as part of the mandatory routine immunization program for children in Nigeria (7).…”

Section: Introductionmentioning

confidence: 99%

Faeco-prevalence of enteric viruses in children under five in Ogun State, Nigeria; a one-year study

Ogunbiyi,

Ayolabi,

Olukoya

et al. 2023

Babcock Univ. Med. J.

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Objective: Acute gastroenteritis has been reported as the second largest cause of preventable child mortality, accounting for an estimated annual 1.5 million deaths. In Nigeria, routine clinical diagnosis of infectious diarrhoea is bacterial-focused, leaving out the viral agents. Therefore, this study was designed to investigate the prevalence, seasonality, and risk factors of selected enteric viruses (EVs): human adenovirus (HAdV), norovirus (NoV), hepatitis A virus (HAV), and human astrovirus (HAstV) infection in children under 5 years old with acute gastroenteritis in Ogun State, Nigeria. Methods: One hundred faecal samples collected from out-patient diarrheal children under five years from six different hospitals between May 2021 and April 2022 were analysed using specific primers for four EVs by nested reverse transcription polymerase chain reaction. Result: Among the samples analysed, 44% were positive for at least one EV. The highest prevalence was recorded in HAdV (29%), followed by HAstV (9%), and NoV (6%). Mixed infections were only found in 3 cases. Additionally, the occurrence of EV infection was observed to be highest in children below 2 years (p = 0.002). A statistically significant (p = 0.03) association was observed between the EVs and the source of drinking water. The seasonal pattern of the EVs showed a marked increase in their incidence during the dry season. Conclusion: This study shows that EVs contribute to the burden of gastroenteritis in Ogun state, hence, continuous monitoring of these pathogens’ epidemiology remains fundamental to effective treatment and prevention of this disease.

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Epidemiology of norovirus infection in Nigeria: a systematic review and meta-analysis

Chigor,

Digwo,

Adediji

et al. 2024

Arch Virol

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Prevalence and relative risk of Rotavirus Gastroenteritis in children under five years in Nigeria: a systematic review and meta-analysis

Cited by 3 publications

References 60 publications

Molecular Characterization and Risk Factors Associated with Rotavirus among Children with diarrhoea.

Molecular Characterization and Risk Factors Associated with Rotavirus among Children with diarrhoea.

Faeco-prevalence of enteric viruses in children under five in Ogun State, Nigeria; a one-year study

Epidemiology of norovirus infection in Nigeria: a systematic review and meta-analysis

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