Abstract:Purpose
To investigate pigment clumping in idiopathic macular telangiectasia type 2 (IMT2) for its incidence, development, and progression during the course of the disease.
Methods
Patients with a diagnosis of IMT2 and greater than 12 months of follow-up were reviewed retrospectively. Measurements of the area of pigment clumping were performed and correlated with visual acuity and findings on spectral domain optical coherence tomography (OCT) and microperimetry (MP1).
Results
Fifty-three eyes in 27 patient… Show more
“…Consistent with the findings of Meleth et al 18 , our data indicate that in the majority (on average 75%) of cases pigment plaques precede subretinal neovascular proliferation. SRNV may however also appear simultaneously with pigment or with no MacTel-type pigment detectable prior to the incidence of SRNV.…”
Section: Discussionsupporting
confidence: 93%
“…Meleth et al 18 noted in a sample of 22 non-neovascular MacTel eyes followed for on average 42.5 months (range=12–79 months) a linear growth rate of 8.3±1.7×10 3 μm 2 /month (mean±SEM) based on measurements in colour fundus photographs.…”
“…Consistent with the findings of Meleth et al 18 , our data indicate that in the majority (on average 75%) of cases pigment plaques precede subretinal neovascular proliferation. SRNV may however also appear simultaneously with pigment or with no MacTel-type pigment detectable prior to the incidence of SRNV.…”
Section: Discussionsupporting
confidence: 93%
“…Meleth et al 18 noted in a sample of 22 non-neovascular MacTel eyes followed for on average 42.5 months (range=12–79 months) a linear growth rate of 8.3±1.7×10 3 μm 2 /month (mean±SEM) based on measurements in colour fundus photographs.…”
“…Pigment clumping is initiated in the areas of outer retinal thinning and disruption, which suggests that atrophic changes in the photoreceptor layer may create a permissive environment for RPE transformation. Pigment clumps increase in size over time, and in some cases, separate pigment clumps can coalesce and form a large contiguous pigment clump [ 6 ]. Similarly, intraretinal migration of RPE can be noted in retinitis pigmentosa and intermediate dry age-related macular degeneration.…”
“…Several investigations showed that early changes in type 1 and 2 MT were associated with differences in macular pigment distributions, seen by autofluorescence spectrometry, and not with vascular abnormalities. Pigment clumping has been noted recently in late-stage idiopathic type 2 MT, revealing that its area is enlarging continuously over time, with associated visual function decline (3).…”
We describe the 6 steps of progression from earlier SD-OCT findings that led to a complete disorganization and fusion of the inner layers (probably due to changes in the Müller cells) to the typical intraretinal cysts.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.