Prevalence and prognostic value of quantified electroencephalogram (EEG) alterations in cirrhotic patients

Amodio, Piero; Piccolo, F. Del; Pettenó, E; Mapelli, Daniela; Angeli, Paolo; Iemmolo, Rosamaria; Muraca, Maurizio; Musto, Carmine; Gerunda, G.E.; Rizzo, Cristiano; Merkel, Carlo; Gatta, Angelo

doi:10.1016/s0168-8278(01)00129-5

Cited by 230 publications

(171 citation statements)

References 16 publications

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“…This is clearly captured by quantitative EEG, which does not detect a reduction in the mean dominant frequency (MDF) of the EEG in, but only an increase of theta activity in the posterior areas of the scalp. 7,[13][14][15] The MDF is a measure of the overall frequency of an EEG interval (called epoch) and, on the computational point of view, is the mean power of each frequency weighted by the frequency rate, according to the formula:…”

Section: The Typical Eeg Findings In Hementioning

confidence: 99%

“…Eye opening reactivity can be reduced analysis of the digitalized EEG provides grading based on the exact quantification of the EEG components. 7,10,14,15,[22][23][24][25] Based on the relative power of frequency bands and MDF over approximately 60 s of EEG over posterior derivations, a classification was obtained that has prognostic value both in terms of survival and risk of development of overt HE 14 ( Table 2). The value of such approach was recently confirmed 26 and a large, validated observational study proved that the use of the MDF of the EEG improves the predictive value of the MELD score.…”

Section: Quantitative Eegmentioning

confidence: 99%

“…The value of such approach was recently confirmed 26 and a large, validated observational study proved that the use of the MDF of the EEG improves the predictive value of the MELD score. 14,27 In well compensated cirrhotic patients the prognostic value of minor EEG changes might be lower than in patients with advanced liver disease. 14,28 In fact, the attribution to HE of any change of brain functional, as well as of cognition, in these patients might be questionable (i.e., it may have low positive predictive value), because the 'a priori' probability of HE is low.…”

Section: Quantitative Eegmentioning

confidence: 99%

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Clinical Neurophysiology of Hepatic Encephalopathy

Amodio

Montagnese

2015

Journal of Clinical and Experimental Hepatology

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Background/Objectives: Hepatic encephalopathy (HE) has relevant impact on the quality of life of patients and their caregivers and causes relevant costs because of hospitalizations and work days lost. Its quantification is important to perform adequate clinical trials on this relevant complication of cirrhosis and portal-systemic shunting. Clinical neurophysiology, which detects functional alterations of the nervous system, has been applied to the study of HE for over 60 years. This review aims at summarizing and clarifying the role of neurophysiologic techniques in the study of HE. Methods: A narrative review was performed aiming at interpreting the cited papers and the techniques on the basis of their physiological and pathophysiological meaning. Results: The potential role of EEG, quantified EEG, evoked potentials-both exogenous, endogenous and motor-have been clarified to the reader that may be unfamiliar with neurophysiology. Conclusions: The EEG, reflecting the oscillatory changes of neural network is the preferable tool to detect and monitor HE, with the exception of its most severe stage, when EEG flattens. SSEP and MEP have indication to detect and monitor transmission alterations that are likely related to myelin changes and microedema. ( J CLIN EXP HEPATOL 2014;5:S60-S68)

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Section: The Typical Eeg Findings In Hementioning

confidence: 99%

Section: Quantitative Eegmentioning

confidence: 99%

Section: Quantitative Eegmentioning

confidence: 99%

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Clinical Neurophysiology of Hepatic Encephalopathy

Amodio

Montagnese

2015

Journal of Clinical and Experimental Hepatology

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“…79 Among evoked responses, the P300 peak obtained in an auditory oddball paradigm is the most sensitive test. [80][81][82][83] These tests can supplement neurological or neuropsychiatric examination. It has been demonstrated that there was a greater likelihood of development of overt HE in cirrhotic patients with abnormal P300 event-related potential latencies and NCT than in patients with no such abnormality.…”

Section: Neurophysiological Testsmentioning

confidence: 99%

“…It has been demonstrated that there was a greater likelihood of development of overt HE in cirrhotic patients with abnormal P300 event-related potential latencies and NCT than in patients with no such abnormality. 80 www.intechopen.com…”

Section: Neurophysiological Testsmentioning

confidence: 99%