Prevalence and Prognostic Implications of Pre-Diabetic State in Patients With Heart Failure

Matsue, Yuya; Suzuki, Makoto; Nakamura, Ryohei; Abe, Masami; Ono, Maki; Yoshida, Satoshi; Seya, Mie; Iwatsuka, Ryota; Mizukami, Akira; Setoguchi, Masahiko; Nagahori, Wataru; Ohno, Masakazu; Matsumura, Akihiko; Hashimoto, Yuji

doi:10.1253/circj.cj-11-0754

Cited by 57 publications

(36 citation statements)

References 29 publications

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“…25 It is also reported that impaired glucose torelance (IGT) in patients with heart failure contributed to poor prognosis in a similar fashion to diabetes mellitus. 26 Many reports indicate that ARB would reduce the incidence of new-onset diabetes in hypertensive patients; 7,8,27-29 there are only a few reports indicating that ARB effectively reduced the number of CV events. In the sub-analysis of the LIFE study, an ARB (losartan) showed a significant reduction of CV events in hypertensive patients who had signs of ECG-LVH and diabetes at study entry (HR: 0.76; 95% CI: 0.58-0.98; P=0.031) compared with a β-blocker (atenolol).…”

Section: Discussionmentioning

confidence: 99%

Retraction：Effects of Valsartan on Cardiovascular Morbidity and Mortality in High-Risk Hypertensive Patients With New-Onset Diabetes Mellitus

Kimura

Sawada

Shiraishi

et al. 2012

Circ J

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Section: Discussionmentioning

confidence: 99%

Retraction：Effects of Valsartan on Cardiovascular Morbidity and Mortality in High-Risk Hypertensive Patients With New-Onset Diabetes Mellitus

Kimura

Sawada

Shiraishi

et al. 2012

Circ J

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“…The prevalence of glucose intolerance in patients with HF was reported in several trials range from 23% to 43% [24][25][26][27] . A recent study conducted in Kameda Medical Center, Chiba, Japan showed that out of 136 subjects 46 (33.82%) had prediabetes, among them 9 (9.6%) had IFG, 37 (39.4%) had IGT 28 .…”

Section: Discussionmentioning

confidence: 98%

“…In a recent study carried out in Division of Cardiology, Department of Medicine, Kameda Medical Center, Chiba, Japan, it was shown that HF patients with IGT tended to have a higher mortality rate than those without glucose intolerance 28 . Two meta-analyses showed that only post-prandial hyperglycemia, but not fasting hyperglycemia, is a good predictor of adverse cardiovascular events 37 .…”

Section: Discussionmentioning

confidence: 99%

Frequency of Diabetes and Prediabetes in Heart Failure Patients and Their Association with In-Hospital Outcome

Begum¹,

Abdullah

Khan³

et al. 2014

Chatt Maa Shi Hosp Med Coll J

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Background: There are an increasing number of hospital admissions due to heart failure with diabetes or prediabetes in different hospitals in Bangladesh. But very little is known about the frequency of diabetes and prediabetes and the effect of its presence on the characteristics and outcome in patients hospitalized for heart failure. The objective of this study was to find out the frequency of diabetes and prediabetes in heart failure patients and to assess their association with in-hospital outcome. Methods: This cross sectional analytical study was done in the department of Biochemistry and Cardiology of Bangabandhu Sheikh Mujib Medical University in collaboration with department of Cardiology of National Institute of Cardiovascular Diseases, and Dhaka Medical College Hospital from July 2010 to June 2011. After proper ethical consideration a total two hundred and fifty heart failure patients were enrolled in the study by nonrandom sampling. Fasting blood sugar was done in all patients and oral glucose tolerance test was done in patients with impaired fasting glycaemia. Results: The frequency of prediabetes among the total population was 12.8% (95% CI,) and that of diabetes was 37.2% (95% CI, 31.2-43.2%). Improvement was achieved in 27 (84.4%) cases in prediabetic group, 75 (80.6%) cases in diabetic group and 105 (84.0%) cases in nondiabetic group. Mortality rates in prediabetes, diabetes and nondiabetes were 5 (15.6%); 18 (19.4%) and 20 (16.0%) respectively. The differences found among the three groups were not statistically significant (p>0.05). Length of hospital stay was also similar in all groups of study subjects. Conclusion: Frequency of diabetes among heart failure patients is high and pre-diabetes is not negligible in our country. Future studies in this field should focus on all types of glucose abnormalities rather than previously diagnosed diabetes only.

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“…However, patients with FBG levels ≥ 7.0 mmol/L had increased all-cause mortality, and FBG levels over 7.0 mmol/L were shown to be an independent predictor of all-cause mortality in patients with DCM. A recent Japanese study demonstrated that IGT and DM contributed to adverse prognoses in patients with HF, but IFG was not identifi ed as a predictor of poor prognosis [ 14 ] . Moreover, even among patients without HF, diastolic function evaluated by echocardiography was shown to be impaired in patients with DM or IGT, but not in those with IFG, when compared to NGT [ 15 ] .…”

Section: Discussionmentioning

confidence: 99%

Fasting Blood Glucose at Admission and Survival in Patients with Dilated Cardiomyopathy: a Single-center Cohort Study

Rong-jian

Kong

et al. 2014

Exp Clin Endocrinol Diabetes

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Prevalence and Prognostic Implications of Pre-Diabetic State in Patients With Heart Failure

Cited by 57 publications

References 29 publications

Retraction：Effects of Valsartan on Cardiovascular Morbidity and Mortality in High-Risk Hypertensive Patients With New-Onset Diabetes Mellitus

Retraction：Effects of Valsartan on Cardiovascular Morbidity and Mortality in High-Risk Hypertensive Patients With New-Onset Diabetes Mellitus

Frequency of Diabetes and Prediabetes in Heart Failure Patients and Their Association with In-Hospital Outcome

Fasting Blood Glucose at Admission and Survival in Patients with Dilated Cardiomyopathy: a Single-center Cohort Study

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