Prevalence and predictors of potential drug-drug interactions

Nikolic, Bozana; Janković, Slobodan; Stojanov, Oliver; Popović, Jovan

doi:10.2478/s11536-013-0272-4

Cited by 14 publications

(29 citation statements)

References 47 publications

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“…This was a little higher compared to a finding from a study in the US which assessed PDDIs in outpatient settings [ 40 ]. However, other studies from Ethiopia and other countries found higher to much higher proportions of PDDIs compared to the current study, reaching up to 78% [ 8 , 10 , 21 , 22 , 41 ]. The difference could be associated with higher number of medicines prescribed per individual in the cited studies and the fact that some were done at inpatient facilities where generally higher number of medicines are prescribed, leading to higher probability of interactions occurring.…”

Section: Discussioncontrasting

confidence: 91%

“…In contrast, a study among medicines prescribed for the elderly, conducted in Brazil, identified being female to be associated with occurrence of PDDIs [ 42 ]. However, a number of other studies found no statistically significant association in terms of sex of patients [ 21 – 24 , 41 ]. Difference in specific conditions/diagnoses between male and female patients could be among the possible reasons.…”

Section: Discussionmentioning

confidence: 97%

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Pattern and Appropriateness of Medicines Prescribed to Outpatients at a University Hospital in Northwestern Ethiopia

Teni

Belachew

Gebresillassie

et al. 2017

BioMed Research International

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The study assessed the pattern and appropriateness of medicines prescribed to outpatients at Gondar University Referral Hospital in northwestern Ethiopia. An institution-based cross-sectional study was employed, through interviews and prescription reviews, among 346 patients at the outpatient pharmacy, from 2nd to 20th of May 2016. Data on sociodemographic profile of patients and medicines prescribed to them were collected. A mean of 1.72 medicines per encounter was prescribed, over a third of the total being anti-infectives. Patients were able to get about 85% of these medicines. An unskilled government employee would be required to work more than one and a half day to be able to afford the average priced medicine. Among prescriptions with two or more medicines, more than a third had at least one potential drug-drug interaction (PDDI), the commonest pair containing amoxicillin and doxycycline. Being male, being older (50–59 years), and increased number of medicines were associated with higher likelihood of PDDIs. In conclusion, the number of medicines prescribed per encounter was up to accepted standard. However, their availability fell short, together with considerable cost. Regarding appropriateness, a significant proportion of potential drug-drug interactions is identified and associated with patient's sex, age, and number of medicines prescribed.

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Section: Discussioncontrasting

confidence: 91%

Section: Discussionmentioning

confidence: 97%

Pattern and Appropriateness of Medicines Prescribed to Outpatients at a University Hospital in Northwestern Ethiopia

Teni

Belachew

Gebresillassie

et al. 2017

BioMed Research International

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“…The most noticeable drug involved in causing pDDIs in this study is pantoprazole But few other studies that have carried out previously has shown that ciprofloxacin and ACE inhibitors are responsible for more number of drug-drug inetractions 23,24 (Nabovati E et al, 2016) (Nikolic B et al, 2014). The results of this study also highlight this area as most of the DDIs were identified in such prescriptions.…”

Section: Discussionsupporting

confidence: 52%

A Study on Potential Drug - Drug Interactions in Medicine Department of a Multi Specialty Teaching Hospital

Shareef

Menezes

Bhat

2017

J. Drug Delivery Ther.

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Aim of study: Drug-drug interaction (DDI) occurs when two or more drugs are simultaneously administered, where the effect of one drug is altered by the concomitant use of another drug. The prospective observational study aimed to assess the potential drug-drug interactions (pDDIs) in general medicine department of a multispecialty teaching hospital. Material & Methods: Data of all the patients admitted in the general medicine department was collected and analyzed for drug-drug interactions by using drug information resources such as "Thomson Reuters MICROMEDEX® 2.0 DRUGDEX and drugs.com. Results: A total of 150 case records were reviewed, 116 (77.33%) cases were identified with 273 potential drug-drug interactions during the study period. It was observed that out of the 273 DDIs identified, majority 68.13% of the interactions were moderate in severity followed by 19.78% were minor and 12.08% were major. The categorization of onset of drug-drug interactions revealed that 53.47% were categorized as 'not specified' and the documentation status of drugdrug interactions showed that 56.77% were 'fair' in nature. Conclusion: The study highlights the need of regular monitoring of drug therapy in identifying and preventing the medications that have the potential to cause drug-drug interactions thereby minimizing the undesirable outcomes in drug therapy and improving the quality of care.

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“…9,10 Some risk factors influence the manifestation of DDIs in populations, such as age group or polypharmacy as well as the nature and number of diseases diagnosed in each patient. 11 Notwithstanding the available information, to our knowledge, there are no studies in Mexico evaluating the prevalence and severity of pharmacological interactions. Furthermore, data from Latin America is limited, so studies that evaluate the prevalence and severity of drug interactions are needed.…”

Section: Introductionmentioning

confidence: 99%

Pilot study: Evaluation of potential drug–drug interactions in hospitalized pediatric patients

Medina-Barajas

Vázquez-Méndez

Pérez-Guerrero

et al. 2020

Pediatrics & Neonatology

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drug-drug interactions; medication errors; pediatric patients; potential drug-drug interactions Purpose: Evaluate the type and severity of potential drug-drug interactions and identify risk factors involved, in pediatric patients admitted in a hospital setting. Methods: Transversal retrospective analytical study was carried out with hospitalized pediatric patients from a Hospital in the West of Mexico, second and third level. The patients included were 18 years old hospitalized in the children wards; those admitted at the emergency room, neonatal intermediate and intensive therapy units were not included. Medical prescriptions were reviewed taking into consideration anthropometric characteristics, diagnosis and number of drugs prescribed to identify potential drugedrug interactions using Micromedex 2.0 database.

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Prevalence and predictors of potential drug-drug interactions

Abstract: Abstract

Cited by 14 publications

References 47 publications

Pattern and Appropriateness of Medicines Prescribed to Outpatients at a University Hospital in Northwestern Ethiopia

Pattern and Appropriateness of Medicines Prescribed to Outpatients at a University Hospital in Northwestern Ethiopia

A Study on Potential Drug - Drug Interactions in Medicine Department of a Multi Specialty Teaching Hospital

Pilot study: Evaluation of potential drug–drug interactions in hospitalized pediatric patients

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