Prevalence and predictors of nonalcoholic fatty liver disease in South Asian women with polycystic ovary syndrome

Shengir, Mohamed; Krishnamurthy, Srinivasan; Ghali, Peter; Deschênes, Marc; Wong, Philip; Chen, Tianyan; Sebastiani, Giada

doi:10.21203/rs.3.rs-39996/v1

Cited by 2 publications

(2 citation statements)

References 40 publications

(59 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…BMI had the highest area under the curve in the Mediation of BMI on the association between HGI and NAFLD. prediction of NAFLD (60). BMI is superior to WC in predicting the risk for NAFLD (61).…”

Section: Discussionmentioning

confidence: 95%

Association between hemoglobin glycation index and non-alcoholic fatty liver disease

Xing

Zhen²,

Yang³

et al. 2023

Front. Endocrinol.

View full text Add to dashboard Cite

ObjectiveThe hemoglobin glycation index (HGI) reflects biological variability in hemoglobin A1c. Even so, studies on the relationship between HGI and non-alcoholic fatty liver disease (NAFLD) are limited. Therefore, this study aimed to explore the relationship between HGI and NAFLD. In addition, the study also aimed to provide new methods to identify patients with a high risk for the development of NAFLD.MethodsThis was a retrospective study based on physical examination data from Japan. Patients were divided into quartiles (Q1–Q4) according to their HGI level; the lowest quartile (Q1) was used as the reference group. Patents were also classified into two subgroups based on the presence or absence of NAFLD. Baseline characteristics between the groups were compared. Multivariate logistic regression analysis was used to investigate the association between the HGI and NAFLD. A mediation analysis examined the mediation relationship between HGI and NAFLD. Subgroup analyses were performed to the reliability of the results.ResultsA total of 14280 patients were eligible for inclusion in this study; 2515 had NAFLD. Patients in the NAFLD group had higher levels of HGI than patients in the non-NAFLD group. Increases in HGI correlated with an increased risk of NAFLD. After adjusting for confounding factors, the multivariate logistic regression analysis revealed that HGI was positively related to the prevalence of NAFLD. In addition, mediation analysis showed that body mass index (BMI) partly mediated the indirect impact of HGI on NAFLD preference. Subgroup analyses were performed according to age, sex, smoking status, and waist circumference. Our results indicated that HGI significantly correlated with NAFLD in patients with one of the following factors: age ≤60 years, BMI >28 kg/m2, female sex, a history of smoking, and abdominal obesity.ConclusionsHGI was an independent risk factor for NAFLD, and BMI partly mediated the association between HGI and NAFLD.

show abstract

Section: Discussionmentioning

confidence: 95%

Association between hemoglobin glycation index and non-alcoholic fatty liver disease

Xing

Zhen²,

Yang³

et al. 2023

Front. Endocrinol.

View full text Add to dashboard Cite

show abstract

“…The SUA/ Scr ratio was transformed into a categorical variable by quintiles and calculated the P for the trend to validate the SUA/Scr ratio as the continuous variable and test for the possibility of non-linearity. As the risk of NAFLD was obviously increased in patients with diabetes mellitus [10], IFG [55], and elevated ALT [56]. Therefore, when exploring the association between the SUA/Scr ratio and NAFLD in other sensitivity analyses, we excluded participants with FPG > 6.1 mmol/L or ALT > 40 U/L.…”

Section: Sensitivity Analysismentioning

confidence: 99%

Association between serum uric acid-to-creatinine ratio and non-alcoholic fatty liver disease: a cross-sectional study in Chinese non-obese people with a normal range of low-density lipoprotein cholesterol

et al. 2022

View full text Add to dashboard Cite

Objective Evidence regarding the relationship between serum uric acid-to-creatinine (SUA/Scr) ratio and non-alcoholic fatty liver disease (NAFLD) in Chinese non-obese people is still limited. Therefore, the present study was undertaken to analyze the association between the SUA/Scr ratio and NAFLD. Methods This study was a cross-sectional study that non-selectively and consecutively collected 182,320 non-obese individuals with a normal range of low-density lipoprotein cholesterol in a Chinese hospital from January 2010 to December 2014. A binary logistic regression model was used to evaluate the independent association between the SUA/Scr ratio and NAFLD. A generalized additive model (GAM) and smooth curve fitting (penalized spline method) was conducted to explore the exact shape of the curve between them. A series of sensitivity analyses were used to ensure the robustness of the results. Moreover, subgroup analyses were conducted. In addition, the diagnostic value of the SUA/Scr ratio for NAFLD was evaluated based on the area under the receiver-operating characteristic curve (AUROC). It was stated that the data had been uploaded to the DATADRYAD website. Results The average participants' age was 40.96 ± 14.05 years old, and 90,305 (49.5%) were male. The prevalence of NAFLD was 13.7%, and the mean SUA/Scr was 3.62 ± 0.92. After adjusting covariates, the results showed that SUA/Scr ratio was positively associated with NAFLD (OR = 1.424, 95%CI: 1.396, 1.454). There was also a non-linear relationship between SUA/Scr ratio and NAFLD in participants with normal kidney function, and the inflection point of the SUA/Scr ratio was 4.425. The effect sizes (OR) on the left and right sides of the inflection point were 1.551 (1.504, 1.599) and 1.234 (1.179, 1.291), respectively. And the sensitive analysis demonstrated the robustness of the results. Subgroup analysis showed a stronger association between SUA/Scr ratio and NAFLD in females and the population with age < 50 years, FPG ≤ 6.1 mmol/L, BMI < 24 kg/m2, and HDL-c ≥ 1 mmol/L. In contrast, the weaker association was probed in males and the population with age ≥ 50 years, BMI ≥ 24 kg/m2, FPG > 6.1 mmol/L, and HDL-c < 1 mmol/L. The SUA/Scr ratio had an AUC of 0.6624 (95% CI 0.6589, 0.6660) for diagnosing NAFLD. Based on the best cut-off value of 3.776, the negative predictive value of the SUA/Scr ratio for identifying NAFLD was 91.0%. Conclusion This study demonstrates an independent positive association between SUA/Scr ratio and NAFLD in Chinese non-obese people with a normal range of low-density lipoprotein cholesterol. There is also a non-linear relationship between the SUA/Scr ratio and NAFLD in participants with normal kidney function, and the SUA/Scr ratio is strongly related to NAFLD when SUA/Scr ratio is less than 4.425. The SUA/Scr ratio has a certain reference value for determining NAFLD. When the SUA/Scr ratio is lower than 3.776, identifying NAFLD patients with low risk is a great reference.

show abstract

Prevalence and predictors of nonalcoholic fatty liver disease in South Asian women with polycystic ovary syndrome

Cited by 2 publications

References 40 publications

Association between hemoglobin glycation index and non-alcoholic fatty liver disease

Association between hemoglobin glycation index and non-alcoholic fatty liver disease

Association between serum uric acid-to-creatinine ratio and non-alcoholic fatty liver disease: a cross-sectional study in Chinese non-obese people with a normal range of low-density lipoprotein cholesterol

Contact Info

Product

Resources

About